| Assay ID | Title | Year | Journal | Article |
|---|
| AID342991 | Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M3 receptor expressed in CHOK1 cells | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
| Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics. |
| AID141200 | Antagonist affinity evaluated against Muscarinic acetylcholine receptor M3 in isolated guinea pig longitudinal Ileum. | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21
| Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists. |
| AID140935 | Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2 | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21
| Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists. |
| AID233262 | Selectivity ratio between Heart (M2) and gland (M3) was determined | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| Synthesis and biological activity of some methoctramine-related tetraamines bearing a 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one moiety as antimuscarinics: a second generation of highly selective M2 muscarinic receptor antagonists. |
| AID142273 | Affinity for Muscarinic acetylcholine receptor M5 expressed in CHO cells by [3H]NMS displacement. | 2001 | Bioorganic & medicinal chemistry letters, May-07, Volume: 11, Issue:9
| Design and pharmacology of quinuclidine derivatives as M2-selective muscarinic receptor ligands. |
| AID142727 | Tested for affinity constant against M1 muscarinic receptor in rat cortex using [3H]pirenzepine | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| Design, synthesis, and biological activity of methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4] benzodiazepin-6-one moiety: structural requirements for optimum occupancy of muscarinic receptor subtypes as revealed b |
| AID141590 | Affinity for Muscarinic acetylcholine receptor M3 expressed in CHO cells by [3H]-NMS displacement. | 2001 | Bioorganic & medicinal chemistry letters, May-07, Volume: 11, Issue:9
| Design and pharmacology of quinuclidine derivatives as M2-selective muscarinic receptor ligands. |
| AID101733 | Antagonistic activity measured in isolated guinea pig left ileum (M3 receptor) | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| Synthesis and biological activity of some methoctramine-related tetraamines bearing a 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one moiety as antimuscarinics: a second generation of highly selective M2 muscarinic receptor antagonists. |
| AID101736 | Affinity constant measured against M3 muscarinic receptor in rat submaxillary gland | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| Synthesis and biological activity of some methoctramine-related tetraamines bearing a 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one moiety as antimuscarinics: a second generation of highly selective M2 muscarinic receptor antagonists. |
| AID142124 | Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21
| Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists. |
| AID104026 | Affinity constant measured against M1 muscarinic receptor in rat cortex | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| Synthesis and biological activity of some methoctramine-related tetraamines bearing a 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one moiety as antimuscarinics: a second generation of highly selective M2 muscarinic receptor antagonists. |
| AID233265 | Selectivity ratio between atrium (M2) and ileum (M3) was determined | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| Synthesis and biological activity of some methoctramine-related tetraamines bearing a 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one moiety as antimuscarinics: a second generation of highly selective M2 muscarinic receptor antagonists. |
| AID142017 | Inhibition of NG 108-15 binding to Muscarinic acetylcholine receptor M4 | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21
| Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists. |
| AID141302 | Affinity for Muscarinic acetylcholine receptor M1 expressed in CHO cells by [3H]NMS displacement. | 2001 | Bioorganic & medicinal chemistry letters, May-07, Volume: 11, Issue:9
| Design and pharmacology of quinuclidine derivatives as M2-selective muscarinic receptor ligands. |
| AID101707 | Affinity constant measured against M2 muscarinic receptor in rat heart r | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| Synthesis and biological activity of some methoctramine-related tetraamines bearing a 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one moiety as antimuscarinics: a second generation of highly selective M2 muscarinic receptor antagonists. |
| AID141011 | Tested for affinity constant against M3 muscarinic receptor in rat submaxillary gland using [3H]NMS | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| Design, synthesis, and biological activity of methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4] benzodiazepin-6-one moiety: structural requirements for optimum occupancy of muscarinic receptor subtypes as revealed b |
| AID233270 | Selectivity ratio between heart (M2) and cortex (M1) was determined | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| Synthesis and biological activity of some methoctramine-related tetraamines bearing a 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one moiety as antimuscarinics: a second generation of highly selective M2 muscarinic receptor antagonists. |
| AID142876 | Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| Design, synthesis, and biological activity of methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4] benzodiazepin-6-one moiety: structural requirements for optimum occupancy of muscarinic receptor subtypes as revealed b |
| AID141738 | Inhibition of [3H]NMS binding to rat submaxillary gland Muscarinic acetylcholine receptor M3 | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21
| Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists. |
| AID142001 | Affinity for Muscarinic acetylcholine receptor M4 expressed in CHO cells by [3H]NMS displacement. | 2001 | Bioorganic & medicinal chemistry letters, May-07, Volume: 11, Issue:9
| Design and pharmacology of quinuclidine derivatives as M2-selective muscarinic receptor ligands. |
| AID342995 | Antagonist activity at peripheral muscarinic M4 receptor in rabbit vas deferens assessed as effect on McN-A-343-induced contraction after 1 hr | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
| Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics. |
| AID342994 | Antagonist activity at peripheral muscarinic M3 receptor in guinea pig longitudinal ileum assessed as effect on arecaidin propargyl ester-induced contraction after 1 hr | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
| Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics. |
| AID101871 | Affinity constant measured against M4 muscarinic receptor rat NG108-15 cells | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| Synthesis and biological activity of some methoctramine-related tetraamines bearing a 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one moiety as antimuscarinics: a second generation of highly selective M2 muscarinic receptor antagonists. |
| AID232491 | Selectivity ratio is the antilog of the difference between the pA2 values at guinea pig left atrium and ileum muscarinic receptors | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| Design, synthesis, and biological activity of methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4] benzodiazepin-6-one moiety: structural requirements for optimum occupancy of muscarinic receptor subtypes as revealed b |
| AID101699 | Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor) | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| Synthesis and biological activity of some methoctramine-related tetraamines bearing a 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one moiety as antimuscarinics: a second generation of highly selective M2 muscarinic receptor antagonists. |
| AID342993 | Antagonist activity at peripheral muscarinic M2 receptor in guinea pig left atrium assessed as effect on arecaidin propargyl ester-induced contraction after 1 hr | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
| Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics. |
| AID141857 | Binding affinity for rat cortex Muscarinic acetylcholine receptor M1 | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21
| Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists. |
| AID142748 | Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist] | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| Design, synthesis, and biological activity of methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4] benzodiazepin-6-one moiety: structural requirements for optimum occupancy of muscarinic receptor subtypes as revealed b |
| AID141023 | Tested for affinity constant against M4 muscarinic receptor in NG 108-15 cell homogenates using [3H]NMS | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| Design, synthesis, and biological activity of methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4] benzodiazepin-6-one moiety: structural requirements for optimum occupancy of muscarinic receptor subtypes as revealed b |
| AID342989 | Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M1 receptor expressed in CHOK1 cells | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
| Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics. |
| AID140997 | Antagonistic activity against M3 muscarinic receptor in guinea pig left ileum derived by plotting log(DR - 1) vs log[antagonist] | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| Design, synthesis, and biological activity of methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4] benzodiazepin-6-one moiety: structural requirements for optimum occupancy of muscarinic receptor subtypes as revealed b |
| AID342992 | Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M4 receptor expressed in CHOK1 cells | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
| Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics. |
| AID142646 | Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement. | 2001 | Bioorganic & medicinal chemistry letters, May-07, Volume: 11, Issue:9
| Design and pharmacology of quinuclidine derivatives as M2-selective muscarinic receptor ligands. |
| AID233260 | Selectivity ratio between Heart (M2) and NG108-15 (M4) was determined | 1993 | Journal of medicinal chemistry, Nov-12, Volume: 36, Issue:23
| Synthesis and biological activity of some methoctramine-related tetraamines bearing a 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one moiety as antimuscarinics: a second generation of highly selective M2 muscarinic receptor antagonists. |
| AID342990 | Displacement of [3H]N-methylscopolamine chloride from human cloned muscarinic M2 receptor expressed in CHOK1 cells | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
| Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics. |
| AID1345326 | Human M2 receptor (Acetylcholine receptors (muscarinic)) | 1994 | European journal of pharmacology, Aug-16, Volume: 268, Issue:3
| Binding profile of the selective muscarinic receptor antagonist tripitramine. |
| AID1345543 | Human M5 receptor (Acetylcholine receptors (muscarinic)) | 1994 | European journal of pharmacology, Aug-16, Volume: 268, Issue:3
| Binding profile of the selective muscarinic receptor antagonist tripitramine. |
| AID1345286 | Human M1 receptor (Acetylcholine receptors (muscarinic)) | 1994 | European journal of pharmacology, Aug-16, Volume: 268, Issue:3
| Binding profile of the selective muscarinic receptor antagonist tripitramine. |
| AID1345343 | Human M3 receptor (Acetylcholine receptors (muscarinic)) | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
| Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics. |
| AID1345465 | Human M4 receptor (Acetylcholine receptors (muscarinic)) | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
| Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |