| Assay ID | Title | Year | Journal | Article |
|---|
| AID197513 | Log concentration to inhibit 5-HTP accumulation was determined in rat brain hemispheres | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID4898 | Binding affinity against 5-hydroxytryptamine 1D receptor alpha expressed in CHO-K1 cells, using [3H]-5-HT as the radioligand. | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
| AID4933 | Binding affinity against 5-hydroxytryptamine 1D receptor beta expressed in CHO-K1 cells, using [3H]5-HT as the radioligand. | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
| AID181111 | compound was tested in vivo for DOPA accumulation in corpus striatum against reserpine-pretreated rats | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
| AID172487 | Compound was tested for 5-HT behavioral response in reserpine pretreated rats; +5HT syndrome | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| (S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists. |
| AID65911 | Displacement of the radioligand [3H]spiperone from D2 receptor | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID65722 | In vitro binding affinity against cloned mammalian Dopamine receptor D2 expressed in CHO cells using [3H]U-86170 as radioligand | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 2. Effects of 8-amino nitrogen substitution on serotonin receptor binding and pharmacology. |
| AID197517 | Log concentration to inhibit DOPA accumulation was determined in rat brain striatum | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID4909 | In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor alpha expressed in CHO cells, by using [3H]5-HT as radioligand | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 2. Effects of 8-amino nitrogen substitution on serotonin receptor binding and pharmacology. |
| AID177335 | In vivo evaluation for DOPA accumulation in the limbic system in male rats (sc) | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| (S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists. |
| AID177323 | In vivo evaluation for DOPA accumulation in the corpus striatum in male rats (sc) | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| (S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists. |
| AID4935 | In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1D receptor beta expressed in CHO cells, by using [3H]5-HT as radioligand | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 2. Effects of 8-amino nitrogen substitution on serotonin receptor binding and pharmacology. |
| AID180739 | The concentration yielding a half maximal decrease of the DOPA was determined in rat brain striatum | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID65724 | In vitro binding affinity against dopamine receptor D2 using [3H]-Raclopride as radioligand in CHO cells (sc) | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| (S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists. |
| AID4367 | In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand. | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 2. Effects of 8-amino nitrogen substitution on serotonin receptor binding and pharmacology. |
| AID180749 | The concentration yielding a half maximal decrease of the DOPA was determined in rat limbic system | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID197514 | Log concentration to inhibit 5-HTP accumulation was determined in rat brain striatum | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID1854986 | Binding affinity to 5-HT1A receptor (unknown origin) assessed as inhibition constant | 2022 | Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16
| Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors. |
| AID181091 | compound was tested in vivo for 5-HTP accumulation in corpus striatum against reserpine-pretreated rats, activity expressed as ED50 | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
| AID4368 | Displacement of the radioligand [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID65725 | Displacement of [3H]spiperone from dopamine receptor D2 | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| (S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists. |
| AID177331 | In vivo evaluation for DOPA accumulation in the hemispheres in male rats at highest test dose of 12.5 uM/Kg (sc); inactive | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| (S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists. |
| AID177315 | In vivo evaluation for 5-HTP accumulation in the corpus striatum in male rats (sc) | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| (S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists. |
| AID4104 | In vitro binding affinity against 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| (S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists. |
| AID181097 | compound was tested in vivo for 5-HTP accumulation in hemispheres (cortex) against reserpine-pretreated rats | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
| AID4370 | Binding affinity against 5-hydroxytryptamine 1A receptor from CHO-K1 cells, using [3H]8-OH-DPAT as the radioligand. | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
| AID180735 | The concentration yielding a half maximal decrease of the DOPA was determined in rat brain hemispheres; inactive at 12.5 umol/kg | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID181105 | compound was tested in vivo for 5-HTP accumulation in limbic system against reserpine-pretreated rats, | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
| AID65755 | In vitro binding affinity against cloned mammalian Dopamine receptor D3 expressed in CHO cells by, using [3H]-spiperone as radioligand | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 2. Effects of 8-amino nitrogen substitution on serotonin receptor binding and pharmacology. |
| AID180540 | The compound was tested in vivo for DOPA accumulation in limbic system against reserpine-pretreated rats | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
| AID180720 | The concentration yielding a half maximal decrease of the 5-HTP was determined in rat brain striatum | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID65618 | Binding affinity against Dopamine receptor D3 from CHO-K1 cells, using [3H]spiperone as the radioligand. | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
| AID177321 | In vivo evaluation for 5-HTP accumulation in the limbic system in male rats (sc) | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| (S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists. |
| AID1855055 | Inhibition of 5-HT1A receptor (unknown origin) | 2022 | Journal of medicinal chemistry, 08-25, Volume: 65, Issue:16
| Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors. |
| AID180724 | The concentration yielding a half maximal decrease of the 5-HTP was determined in rat limbic system | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID65913 | Binding affinity against Dopamine receptor D2 from CHO-K1 cells, using [3H]U-86,170 as the radioligand. | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
| AID197515 | Log concentration to inhibit 5-HTP accumulation was determined in rat limbic system | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID177319 | In vivo evaluation for 5-HTP accumulation in the hemispheres in male rats (sc) | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| (S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists. |
| AID180715 | The concentration yielding a half maximal decrease of the 5-HTP was determined in rat brain hemispheres | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID4102 | In vitro binding affinity against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand in CHO cells (sc) | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| (S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists. |
| AID224035 | Motor activity was measured by motility testing on injecting the compound subcutaneously into rats at the dose of 12.5 umol/kg | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID197518 | Log concentration to inhibit DOPA accumulation was determined in rat limbic system | 1994 | Journal of medicinal chemistry, Sep-30, Volume: 37, Issue:20
| 6,7,8,9-Tetrahydro-N,N-di-n-propyl-3H-benzindol-8-amines. Derivatives as potent and orally active serotonin 5-HT1A receptor agonists. |
| AID180539 | The compound was tested in vivo for DOPA accumulation in hemispheres (cortex) against reserpine-pretreated rats;I= inactive at the highest dose tested | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12
| Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |