zampanolide and Melanoma

zampanolide has been researched along with Melanoma* in 1 studies

Other Studies

1 other study(ies) available for zampanolide and Melanoma

ArticleYear
Microtubule destabilization is a critical checkpoint of chemotaxis and transendothelial migration in melanoma cells but not in T cells.
    Cell adhesion & migration, 2021, Volume: 15, Issue:1

    Microtubules (MTs) control cell shape and intracellular cargo transport. The role of MT turnover in the migration of slow-moving cells through endothelial barriers remains unclear. To irreversibly interfere with MT disassembly, we have used the MT-stabilizing agent zampanolide (ZMP) in Β16F10 melanoma as amodel of slow-moving cells. ZMP-treated B16 cells failed to follow chemotactic gradients across rigid confinements and could not generate stable sub-endothelial pseudopodia under endothelial monolayers. In vivo, ZMP-treated Β16 cells failed to extravasate though lung capillaries. In contrast to melanoma cells, the chemotaxis and transendothelial migration of ZMP-treated Tcells were largely conserved. This is afirst demonstration that MT disassembly is akey checkpoint in the directional migration of cancer cells but not of lymphocytes.

    Topics: Animals; Cell Line, Tumor; Cell Movement; Chemotaxis; Macrolides; Male; Melanoma; Mice; Mice, Inbred C57BL; Microtubules; Pseudopodia; T-Lymphocytes; Transendothelial and Transepithelial Migration

2021