taccalonolide AJ: isolated from plants of the genus Tacca; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 56926890 |
| CHEMBL ID | 2408398 |
| MeSH ID | M0571891 |
| Synonym |
|---|
| CHEMBL2408398 |
| taccalonolide aj |
| 1349904-82-0 |
| [(1s,2s,3r,5s,7s,9s,10r,11r,12s,13s,14r,15r,16s,17s,18s,20s,23s,24s,25r,26r)-10,14-diacetyloxy-3,23,26-trihydroxy-11,15,17,23,24-pentamethyl-4,22-dioxo-8,19,21-trioxaoctacyclo[13.11.0.02,12.05,11.07,9.016,25.018,20.020,24]hexacosan-13-yl] acetate |
| HY-N4208 |
| CS-0032438 |
| MS-31071 |
| PD125320 |
| AKOS040760730 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " The hypothesis that pharmacokinetic differences underlie the differential efficacies of taccalonolides AF and AJ was tested." | ( Pharmacokinetic Analysis and in Vivo Antitumor Efficacy of Taccalonolides AF and AJ. Benavides, R; Cichewicz, RH; Du, L; Kuhn, JG; Li, J; Mooberry, SL; Risinger, AL; Robles, AJ, 2017) | 0.46 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1177715 | Antiproliferative activity against human HeLa cells by SRB assay | 2014 | Bioorganic & medicinal chemistry, Sep-15, Volume: 22, Issue:18 | Taccalonolide microtubule stabilizers. |
| AID1180503 | Antiproliferative activity against human HeLa cells by SRB assay | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14 | Synthetic reactions with rare taccalonolides reveal the value of C-22,23 epoxidation for microtubule stabilizing potency. |
| AID1625143 | Induction of porcine tubulin polymerization measured at 1 min interval for 1 hr | 2019 | Journal of natural products, 03-22, Volume: 82, Issue:3 | Identification of C-6 as a New Site for Linker Conjugation to the Taccalonolide Microtubule Stabilizers. |
| AID1180516 | Ratio of taccalonolide B IC50 to compound IC50 for human HeLa cells by SRB assay | 2014 | Journal of medicinal chemistry, Jul-24, Volume: 57, Issue:14 | Synthetic reactions with rare taccalonolides reveal the value of C-22,23 epoxidation for microtubule stabilizing potency. |
| AID762821 | Antiproliferative activity against human HeLa cells | 2013 | Journal of natural products, Jul-26, Volume: 76, Issue:7 | Hydrolysis reactions of the taccalonolides reveal structure-activity relationships. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 11 (91.67) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.94) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (8.33%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 11 (91.67%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||