Compounds > tyrosyl-alanyl-glycyl-phenylalaninamide

tyrosyl-alanyl-glycyl-phenylalaninamide and Neuralgia

tyrosyl-alanyl-glycyl-phenylalaninamide has been researched along with Neuralgia* in 1 studies

Other Studies

1 other study(ies) available for tyrosyl-alanyl-glycyl-phenylalaninamide and Neuralgia

Article	Year
Development of potent μ and δ opioid agonists with high lipophilicity. Journal of medicinal chemistry, 2011, Jan-13, Volume: 54, Issue:1 An SAR study on the Dmt-substituted enkephalin-like tetrapeptide with a N-phenyl-N-piperidin-4-ylpropionamide moiety at the C-terminal was performed and has resulted in highly potent ligands at μ and δ opioid receptors. In general, ligands with the substitution of D-Nle(2) and halogenation of the aromatic ring of Phe(4) showed highly increased opioid activities. Ligand 6 with good biological activities in vitro demonstrated potent in vivo antihyperalgesic and antiallodynic effects in the tail-flick assay. Topics: Amides; Analgesics, Opioid; Animals; Binding, Competitive; Cell Membrane Permeability; CHO Cells; Cricetinae; Cricetulus; Humans; Hyperalgesia; Ileum; In Vitro Techniques; Ligands; Male; Mice; Muscle, Smooth; Neuralgia; Oligopeptides; Piperidines; Propionates; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens	2011

Article

Year

Development of potent μ and δ opioid agonists with high lipophilicity.

Journal of medicinal chemistry, 2011, Jan-13, Volume: 54, Issue:1

An SAR study on the Dmt-substituted enkephalin-like tetrapeptide with a N-phenyl-N-piperidin-4-ylpropionamide moiety at the C-terminal was performed and has resulted in highly potent ligands at μ and δ opioid receptors. In general, ligands with the substitution of D-Nle(2) and halogenation of the aromatic ring of Phe(4) showed highly increased opioid activities. Ligand 6 with good biological activities in vitro demonstrated potent in vivo antihyperalgesic and antiallodynic effects in the tail-flick assay.

Topics: Amides; Analgesics, Opioid; Animals; Binding, Competitive; Cell Membrane Permeability; CHO Cells; Cricetinae; Cricetulus; Humans; Hyperalgesia; Ileum; In Vitro Techniques; Ligands; Male; Mice; Muscle, Smooth; Neuralgia; Oligopeptides; Piperidines; Propionates; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens

2011