prostaglandin J receptor activity

Definition

Target type: molecularfunction

Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity. [PMID:12878180]

Prostaglandin J receptor activity is a molecular function associated with the binding and recognition of prostaglandin J2 (PGJ2) by its specific receptor, known as the peroxisome proliferator-activated receptor gamma (PPARγ). This interaction triggers a cascade of events that ultimately regulate gene expression and cellular processes.

PGJ2, a potent lipid mediator derived from arachidonic acid, exhibits a wide range of biological activities, including anti-inflammatory, anti-proliferative, and pro-apoptotic effects. These effects are mediated through its binding to PPARγ, a nuclear receptor that plays a crucial role in regulating lipid metabolism, glucose homeostasis, and immune responses.

Upon binding to PPARγ, PGJ2 undergoes a conformational change, which facilitates the recruitment of coactivator proteins. These coactivators, in turn, interact with specific DNA sequences known as peroxisome proliferator response elements (PPREs) located in the promoters of target genes. The binding of PPARγ to PPREs initiates the transcription of genes involved in various physiological processes.

The molecular function of prostaglandin J receptor activity is characterized by the following key features:

1. **Ligand Recognition:** PPARγ exhibits high affinity and selectivity for PGJ2, demonstrating its ability to distinguish PGJ2 from other prostaglandins and lipids.
2. **Conformational Change:** Binding of PGJ2 induces a conformational shift in PPARγ, exposing its DNA-binding domain and facilitating the recruitment of coactivator proteins.
3. **Transcriptional Regulation:** The interaction of PPARγ with coactivators promotes the transcription of target genes by facilitating the binding of the receptor to PPREs within their promoters.
4. **Biological Effects:** The transcriptional regulation mediated by PPARγ activation by PGJ2 results in a wide range of biological effects, including modulation of inflammation, cell growth, and apoptosis.

In summary, prostaglandin J receptor activity encompasses the specific recognition, binding, and signal transduction of PGJ2 by PPARγ, ultimately leading to the regulation of gene expression and diverse biological processes.'
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Proteins (2)

Compounds (32)