Page last updated: 2024-11-12

losigame

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

losigame: tetronic acid derivative [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10131269
MeSH IDM0179937

Synonyms (24)

Synonym
losigamone
2(5h)-furanone, 5-((2-chlorophenyl)hydroxymethyl)-4-methoxy-, (r*,s*)-
losigame
5-(2-chlorophenylhydroxymethyl)-4-methoxy-2-(5h)-furanone
(5r*)-5-((alpha-s*)-o-chloro-alpha-hydroxybenzyl)-4-methoxy-2(5h)-furanone
losigamonum [inn-latin]
losigamona [inn-spanish]
(r*,s*)-5-((2-chlorophenyl)hydroxymethyl)-4-methoxy-2(5h)-furanone
(5r*)-5-((alphas*)-o-chloro-alpha-hydroxybenzyl)-4-methoxy-2(5h)-furanone
ao 33
losigamone [inn]
112856-44-7
(2r)-2-[(s)-(2-chlorophenyl)-hydroxymethyl]-3-methoxy-2h-furan-5-one
84r8o3qm2g ,
losigamonum
losigamona
unii-84r8o3qm2g
(5r*)-5-((.alpha.s*)-o-chloro-.alpha.-hydroxybenzyl)-4-methoxy-2(5h)-furanone
losigamone [mart.]
2(5h)-furanone, 5-[(r)-(2-chlorophenyl)hydroxymethyl]-4-methoxy-, (5s)-rel-
(2s)-2-[(r)-(2-chlorophenyl)-hydroxymethyl]-3-methoxy-2h-furan-5-one
(+/-)-losigamone
DTXSID20869555
AKOS040748760

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Adverse events during treatment were reported by 58."( Efficacy and safety of Losigamone in partial seizures: a randomized double-blind study.
Baulac, M; Klement, S, 2003
)
0.32

Pharmacokinetics

ExcerptReferenceRelevance
"The mean values of the pharmacokinetic parameters AUC and Cmax of ethinylestradiol and levonorgestrel after multiple-dose treatment with losigamone or placebo were quite similar and met the criteria for bioequivalence."( Influence of losigamone on the pharmacokinetics of a combined oral contraceptive in healthy female volunteers.
Dienel, A; Klement, S; Müller, F, 2004
)
0.32

Dosage Studied

ExcerptRelevanceReference
" A positive association between dosage and response was observed (P=0."( Efficacy and safety of Losigamone in partial seizures: a randomized double-blind study.
Baulac, M; Klement, S, 2003
)
0.32
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (24)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's11 (45.83)18.2507
2000's9 (37.50)29.6817
2010's4 (16.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials6 (21.43%)5.53%
Reviews7 (25.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (53.57%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]