8-O-acetylharpagide: an iridoid isolated from Ajuga raptans [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Ajuga | genus | A plant genus of the family LAMIACEAE that contains cyasterone, ajugasterone, 20-hydroxyecdysone, 8-acetylharpagide (an iridoid glycoside).[MeSH] | Lamiaceae | The mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 13565727 |
| MeSH ID | M0208358 |
| Synonym |
|---|
| 8-o-acetylharpagide |
8-O-acetylharpagide was metabolized to harpagide, which affected the pharmacokinetic profiles of har pagide when dosed as the extract. Concentrations of 8-O acetyl harpgide and harpgide in plasma were determined by LC-MS/MS method at different time points.
| Excerpt | Reference | Relevance |
|---|---|---|
| " Concentrations of 8-O-acetylharpagide and harpagide in plasma were determined by LC-MS/MS method at different time points and all pharmacokinetic parameters were estimated by non-compartmental analysis." | ( Pharmacokinetics of 8-O-acetylharpagide and harpagide after oral administration of Ajuga decumbens Thunb extract in rats. He, R; Li, J; Li, P; Lu, Y; Peng, B; Wen, B; Xu, Q, 2013) | 0.39 |
| " Pharmacokinetic parameters of both glycosides were essentially the same except Tmax when dosed as the extract or pure forms." | ( Pharmacokinetics of 8-O-acetylharpagide and harpagide after oral administration of Ajuga decumbens Thunb extract in rats. He, R; Li, J; Li, P; Lu, Y; Peng, B; Wen, B; Xu, Q, 2013) | 0.39 |
| "8-O-acetylharpagide was metabolized to harpagide, which affected the pharmacokinetic profiles of harpagide when dosed as the extract." | ( Pharmacokinetics of 8-O-acetylharpagide and harpagide after oral administration of Ajuga decumbens Thunb extract in rats. He, R; Li, J; Li, P; Lu, Y; Peng, B; Wen, B; Xu, Q, 2013) | 0.39 |
| " Concentrations of 8-O-acetylharpagide and harpagide in plasma were determined by LC-MS/MS method at different time points and all pharmacokinetic parameters were estimated by non-compartment analysis." | ( [Pharmacokinetics of 8-O-acetylharpagide and harpagide after oral administration of Ajuga decumbens extract in beagle dog]. Li, JR; Wen, BY, 2013) | 0.39 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " Pharmacokinetic parameters of both glycosides were essentially the same except Tmax when dosed as the extract or pure forms." | ( Pharmacokinetics of 8-O-acetylharpagide and harpagide after oral administration of Ajuga decumbens Thunb extract in rats. He, R; Li, J; Li, P; Lu, Y; Peng, B; Wen, B; Xu, Q, 2013) | 0.39 |
| "8-O-acetylharpagide was metabolized to harpagide, which affected the pharmacokinetic profiles of harpagide when dosed as the extract." | ( Pharmacokinetics of 8-O-acetylharpagide and harpagide after oral administration of Ajuga decumbens Thunb extract in rats. He, R; Li, J; Li, P; Lu, Y; Peng, B; Wen, B; Xu, Q, 2013) | 0.39 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 6 (40.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 16 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||