complestatin and Hemolysis
complestatin has been researched along with Hemolysis* in 2 studies
Other Studies
2 other study(ies) available for complestatin and Hemolysis
Article | Year |
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Complestatin, a potent anti-complement substance produced by Streptomyces lavendulae. I. Fermentation, isolation and biological characterization.
A new potent inhibitor of complement system, named complestatin, was isolated from the mycelium of Streptomyces lavendulae SANK 60477. Complestatin (C61H45N7O15Cl6, MW 1,325) was a peptide compound having two unusual amino acids, D-(-)-4-hydroxyphenylglycine and D-(-)-3,5-dichloro-4-hydroxyphenylglycine. This compound inhibited the hemolysis of sensitized sheep erythrocytes (EA) mediated by guinea pig and human complement 50% at concentrations of 0.4 and 0.7 micrograms/ml, respectively, but did not trypsin and alpha-chymotrypsin activities at 200 micrograms/ml. When complestatin was administered intravenously to the sensitized guinea pigs, it strongly inhibited the systemic anaphylactic shock elicited by the antigen probably by blocking generation of anaphylatoxins (C3a and C5a). Topics: Amino Acids; Anaphylaxis; Animals; Anti-Bacterial Agents; Chlorophenols; Chymotrypsin; Complement Activation; Complement Inactivator Proteins; Erythrocytes; Fermentation; Guinea Pigs; Hemolysis; Peptides, Cyclic; Streptomyces; Trypsin | 1989 |
Inhibition of the alternative pathway of human complement in vitro by a natural microbial product, complestatin.
Topics: Amino Acids; Animals; Chlorophenols; Complement Activation; Complement C3-C5 Convertases; Complement C3b; Complement Pathway, Alternative; Dose-Response Relationship, Drug; Erythrocytes; Hemolysis; Humans; Peptides, Cyclic; Rabbits; Receptors, Complement; Sheep; Streptomyces | 1980 |