Compounds > belactosin c
Page last updated: 2024-11-12

belactosin c

Description

belactosin C: isolated from Streptomyces; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10666031
CHEMBL ID1783833
SCHEMBL ID3448978
MeSH IDM0360003

Synonyms (3)

Synonym
CHEMBL1783833
belactosin c
SCHEMBL3448978
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1225669Inhibition of chymotrypsin-like activity of rabbit 20S proteasome using Suc-LLVY-AMC as substrate after 2 hrs by fluorescence assay2015Journal of natural products, Apr-24, Volume: 78, Issue:4
Cystargolides, 20S Proteasome Inhibitors Isolated from Kitasatospora cystarginea.
AID599460Antiproliferative activity against human HeLaS3 cells after 72 hrs2009Bioorganic & medicinal chemistry letters, Jun-15, Volume: 19, Issue:12
Synthesis and biological evaluation of boron peptide analogues of Belactosin C as proteasome inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (58.33)29.6817
2010's5 (41.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.53 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index5.10 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.53)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
3-hydroxybutanal
[no description available]		2.0310
bortezomib
[no description available]		2.4820amino acid amide;
L-phenylalanine derivative;
pyrazines		antineoplastic agent;
antiprotozoal drug;
protease inhibitor;
proteasome inhibitor
leupeptins
Leupeptins: A group of acylated oligopeptides produced by Actinomycetes that function as protease inhibitors. They have been known to inhibit to varying degrees trypsin, plasmin, KALLIKREINS, papain and the cathepsins.		2.0610
benzyloxycarbonylleucyl-leucyl-leucine aldehyde
benzyloxycarbonylleucyl-leucyl-leucine aldehyde: proteasome inhibitor. N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal : A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.		2.4620amino aldehyde;
carbamate ester;
tripeptide		proteasome inhibitor
orlistat
Orlistat: A lactone derivative of LEUCINE that acts as a pancreatic lipase inhibitor to limit the absorption of dietary fat; it is used in the management of obesity.. orlistat : A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug.		7.1510beta-lactone;
carboxylic ester;
formamides;
L-leucine derivative		anti-obesity agent;
bacterial metabolite;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor
alpha-chymotrypsin
Chymotrypsin: A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side.		2.4520
boron
Boron: A trace element with the atomic symbol B, atomic number 5, and atomic weight [10.806; 10.821]. Boron-10, an isotope of boron, is used as a neutron absorber in BORON NEUTRON CAPTURE THERAPY.		7.0510boron group element atom;
metalloid atom;
nonmetal atom		micronutrient
carfilzomib
[no description available]		2.1110epoxide;
morpholines;
tetrapeptide		antineoplastic agent;
proteasome inhibitor
glyoxamide
glyoxamide : The simplest of the class of glyoxamides, with no substitution on nitrogen.		2.0310glyoxamides
belactosin a
belactosin A: isolated from Streptomyces; structure in first source		8.4470
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Cervix
[description not available]		02.0610
Uterine Cervical Neoplasms
Tumors or cancer of the UTERINE CERVIX.		02.0610
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