proteasome regulatory particle, lid subcomplex

Definition

Target type: cellularcomponent

The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex. [GOC:rb]

The proteasome regulatory particle (RP) is a multi-subunit complex responsible for recognizing, unfolding, and delivering proteins to the proteasome core particle for degradation. The RP is composed of two subcomplexes: the lid and the base. The lid subcomplex sits atop the base and is responsible for recognizing polyubiquitinated proteins and delivering them to the base for unfolding and degradation. The lid subcomplex is composed of nine subunits: Rpn3, Rpn5, Rpn6, Rpn7, Rpn8, Rpn9, Rpn10, Rpn11, and Rpn12. These subunits are arranged in a ring-like structure, with Rpn3, Rpn5, Rpn6, Rpn7, and Rpn8 forming the outer ring and Rpn9, Rpn10, Rpn11, and Rpn12 forming the inner ring. The lid subcomplex contains several key enzymatic activities, including deubiquitinase activity (Rpn11), ATPase activity (Rpn5 and Rpn6), and ubiquitin-binding activity (Rpn10). These activities are essential for the efficient recognition, unfolding, and delivery of polyubiquitinated proteins to the proteasome core particle for degradation. The lid subcomplex also plays a role in regulating the activity of the proteasome. For example, the lid subcomplex can block the entry of substrates into the proteasome core particle, thereby preventing the degradation of non-ubiquitinated proteins.'
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Proteins (7)

Compounds (7)