proteasome storage granule

Definition

Target type: cellularcomponent

An aggregation of proteasome core protease (CP) and regulatory particle (RP) complexes that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state. [GOC:krc, GOC:rb, PMID:18504300, PMID:30204036]

Proteasome storage granules are cellular compartments that specifically sequester proteasomes, the primary protein degradation machinery in eukaryotic cells. These granules are dynamic structures that form in response to various cellular stresses, such as heat shock, oxidative stress, and nutrient deprivation. They serve as a reservoir for proteasomes, ensuring their availability when needed for protein degradation. The granules are characterized by their spherical or ellipsoidal shape and are typically located in the cytoplasm. They are enriched in proteasomes and other proteins involved in proteasome assembly and function, including chaperones and proteasome-associated proteins. The formation of proteasome storage granules is regulated by specific signaling pathways, including the heat shock response pathway. These granules are essential for maintaining cellular homeostasis by ensuring efficient protein degradation under stress conditions. They also play a role in proteasome quality control, ensuring that only functional proteasomes are available for protein degradation.'
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Proteins (2)

Compounds (3)