salinosporamide

Family of cytotoxic secondary metabolites produced by the marine actinomycete Salinispora tropica.

ChEBI ID: 48046

Members (2)

Member	Definition	Role
marizomib	A salinosporamide in which the core (1R)-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione skeleton is substituted at positions 1, 4, and 5 by (1S)-cyclohex-2-en-1-yl(hydroxy)methyl, 2-chloroethyl, and methyl groups, respectively (the 1R,4R,5S diastereoisomer). A potent proteasome inhibitor, it has attracted interest for potential use in the treatment of various cancers.	salinosporamide A
salinosporamide b		salinosporamide B