Family of cytotoxic secondary metabolites produced by the marine actinomycete Salinispora tropica.
ChEBI ID: 48046
| Member | Definition | Role |
|---|---|---|
| marizomib | A salinosporamide in which the core (1R)-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione skeleton is substituted at positions 1, 4, and 5 by (1S)-cyclohex-2-en-1-yl(hydroxy)methyl, 2-chloroethyl, and methyl groups, respectively (the 1R,4R,5S diastereoisomer). A potent proteasome inhibitor, it has attracted interest for potential use in the treatment of various cancers. | salinosporamide A |
| salinosporamide b | salinosporamide B |
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 57 (44.53) | 29.6817 |
| 2010's | 62 (48.44) | 24.3611 |
| 2020's | 9 (7.03) | 2.80 |
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 4 (2.94%) | 5.53% |
| Reviews | 29 (21.32%) | 6.00% |
| Case Studies | 1 (0.74%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 102 (75.00%) | 84.16% |