antroquinonol-d has been researched along with acetonitrile* in 1 studies
1 other study(ies) available for antroquinonol-d and acetonitrile
| Article | Year |
|---|---|
A short synthesis of (±)-antroquinonol in an unusual scaffold of 4-hydroxy-2-cyclohexenone.
Antroquinonol, which was first isolated from a mushroom, Antrodia cinnamomea, found in Taiwan, is an anticancer compound with a unique core structure of 4-hydroxy-2,3-dimethoxycyclohex-2-enone carrying methyl, farnesyl and hydroxyl substituents in the 4,5-cis-5,6-trans configuration. A short synthesis of (±)-antroquinonol is accomplished in seven steps from 2,3,4-trimethoxyphenol, which is oxidized in methanol to a highly electron-rich substrate of 2,3,4,4-tetramethoxycyclohexadienone and then a Michael reaction with dimethylcuprate is performed as the key step, followed by alkylation, reduction and epimerization to incorporate the required substituents at three contiguous stereocenters. Topics: Acetonitriles; Alkylation; Carbon-13 Magnetic Resonance Spectroscopy; Chloroform; Cyclohexanols; Cyclohexanones; Hydrolysis; Molecular Conformation; Proton Magnetic Resonance Spectroscopy; Stereoisomerism; Ubiquinone | 2015 |