selenium binding

Definition

Target type: molecularfunction

Binding to a selenium (Se) ion. [GOC:ai]

Selenium binding is a molecular function that describes the ability of a protein or molecule to interact with selenium. Selenium is an essential trace element that plays a critical role in various biological processes. It is incorporated into selenoproteins, which are a group of proteins containing selenocysteine, the 21st amino acid. Selenium binding is crucial for the catalytic activity of selenoproteins, which act as antioxidants, redox enzymes, and participate in thyroid hormone metabolism. Specifically, selenoproteins often contain a selenocysteine residue at their active site, which is directly involved in binding selenium. The interaction between selenium and the selenoprotein is generally characterized by a strong affinity, forming a stable bond. This interaction allows selenium to participate in redox reactions, facilitating the transfer of electrons. Selenium binding is essential for the proper function of a variety of metabolic pathways, including the antioxidant defense system, DNA synthesis, and immune response. Defects in selenium binding can lead to various health problems, including infertility, thyroid disorders, and increased risk of certain cancers. '
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Proteins (1)

Compounds (4)