Compounds > phenylglycine nitrile
Page last updated: 2024-09-24

phenylglycine nitrile

Description

phenylglycine nitrile: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID76372
CHEMBL ID1229843
SCHEMBL ID197012
MeSH IDM0444749

Synonyms (45)

Synonym
einecs 221-129-0
n-phenylglycinenitrile
ai3-02755
acetonitrile, phenylamino-
brn 2206191
nsc 7611
CHEMBL1229843
xbn69be6x2 ,
unii-xbn69be6x2
ec 221-129-0
3009-97-0
acetonitrile, anilino-
1-anilinoacetonitrile
nsc7611
wln: nc1mr
glycinonitrile, n-phenyl-
acetonitrile, (phenylamino)-
phenylglycine nitrile
anilinoacetonitrile
(phenylamino)acetonitrile
nsc-7611
n-(cyanomethyl)aniline
2-anilinoacetonitrile
AKOS000253573
HMS1719B17
A820195
2-(phenylamino)acetonitrile
n-phenylglycinonitrile
FT-0634598
SCHEMBL197012
n-cyanomethylaniline
KAXCEFLQAYFJKV-UHFFFAOYSA-N
mfcd00044430
W-106957
n-phenylglycinonitrile, aldrichcpr
acetonitrile, anilino- (8ci)
DTXSID80184175
Z56347332
phenylaminoacetonitril
EN300-16652
STR05177
H12014
Q27452740
acetonitrile, 2-(phenylamino)-
CS-W021451

Bioassays (4)

Assay IDTitleYearJournalArticle
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID1640019Luciferase/luciferin-expressing antifolate-resistant parasites were used to infect a culture of HepG2 cells that were pre-incubated with compounds. Infected hepatocytes emit light due to the luciferase reaction. Assay results are presented as the percent 2018Science (New York, N.Y.), 12-07, Volume: 362, Issue:6419
Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.
AID1640018Luciferase/luciferin-expressing antifolate-resistant parasites were used to infect a culture of HepG2 cells that were pre-incubated with compounds. Infected hepatocytes emit light due to the luciferase reaction. Assay results are presented as the percent 2018Science (New York, N.Y.), 12-07, Volume: 362, Issue:6419
Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's5 (83.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
acridone[no description available]medium10acridines;
cyclic ketone
ethacridine[no description available]medium10acridines
amiodarone[no description available]medium101-benzofurans;
aromatic ketone;
organoiodine compound;
tertiary amino compound		cardiovascular drug
ym 58483[no description available]medium10
camphor, (+-)-isomer[no description available]medium10bornane monoterpenoid;
cyclic monoterpene ketone		plant metabolite
carbonyl cyanide m-chlorophenyl hydrazone[no description available]medium10hydrazone;
monochlorobenzenes;
nitrile		antibacterial agent;
geroprotector;
ionophore
carbonyl cyanide p-trifluoromethoxyphenylhydrazone[no description available]medium10aromatic ether;
hydrazone;
nitrile;
organofluorine compound		ATP synthase inhibitor;
geroprotector;
ionophore
papaverine[no description available]medium10benzylisoquinoline alkaloid;
dimethoxybenzene;
isoquinolines		antispasmodic drug;
vasodilator agent
pimobendan[no description available]medium10benzimidazoles;
pyridazinone		cardiotonic drug;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
vasodilator agent
terfenadine[no description available]medium10diarylmethane
n-isopropyl-n-phenyl-4-phenylenediamine[no description available]medium10N-substituted diamineallergen;
antioxidant
3-amino-9-ethylcarbazole[no description available]medium10carbazoles
cycloguanil[no description available]medium10triazinesantifolate;
antiinfective agent;
antimalarial;
antiparasitic agent;
antiprotozoal drug;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor
2,4,6-trichlorophenyl 4-nitrophenyl ether[no description available]medium10aromatic ether;
C-nitro compound;
chlorobenzenes		EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide
2-phenylthiazolidine-4-carboxylic acid[no description available]medium10
benz(cd)indol-2(1h)-one[no description available]medium10
tetraphenylcyclopentadienone[no description available]medium10stilbenoid
3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine[no description available]medium101,2,4-triazines
honokiol[no description available]medium10biphenyls
bathophenanthroline[no description available]medium10benzenes;
phenanthrolines		chelator
2-phenyl-4,5-dichloro-3-pyridazinone[no description available]medium10
n-benzylmaleimide[no description available]medium10
4,5-dimethyl-1,2-phenylenediamine[no description available]medium10
mmv665852[no description available]medium10
n-(2-methoxyphenyl)maleimide[no description available]medium10
2-aminoperimidine[no description available]medium10
1,3-bis(3-chlorophenyl)urea[no description available]medium10ureas
2-phenyl-4-oxohydroquinoline[no description available]medium10
2-chloro-3-(4-methylanilino)naphthalene-1,4-dione[no description available]medium101,4-naphthoquinones
mequindox[no description available]medium10
1,3-bis(3,5-dichlorophenyl)urea[no description available]medium10
dienestrol[no description available]medium10
cinnamoylglycine[no description available]medium10N-acylglycinemetabolite
4-(4-ethoxyphenyl)-4-oxobutanoic acid[no description available]medium10aromatic ketone
3-(4-chlorophenyl)-5-propyl-1H-pyrazolo[1,5-a]pyrimidin-7-one[no description available]medium10pyrazoles;
ring assembly
N-[4-[methyl(phenyl)sulfamoyl]phenyl]-2-thiophenecarboxamide[no description available]medium10aromatic amide
4-chloro-N-[3-cyano-4-(phenylthio)phenyl]benzamide[no description available]medium10benzamides
3-(4-morpholinyl)-4-(2-pyridinyl)-N-[3-(trifluoromethyl)phenyl]-1-pyrazolecarboxamide[no description available]medium10pyrazolopyridine
7-chloro-2-methyl-4-(4-methylphenyl)sulfonylthiazolo[5,4-b]indole[no description available]medium10sulfonamide
4-[2-[(2,6-dimethoxyphenyl)-oxomethoxy]-1-oxoethyl]-2,5-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester[no description available]medium10methoxybenzoic acid
2-(1H-benzimidazol-2-ylthio)-1-(2,5-dimethyl-1-prop-2-enyl-3-pyrrolyl)ethanone[no description available]medium10benzimidazoles
2,3-dihydro-1,4-dioxin-5-carboxylic acid [2-[4-[4-(2-methylbutan-2-yl)phenoxy]anilino]-2-oxoethyl] ester[no description available]medium10aromatic ether
2-(1,3-benzoxazol-2-ylthio)-1-(2,5-dimethyl-1-prop-2-enyl-3-pyrrolyl)ethanone[no description available]medium10benzoxazole
3-(4-chlorophenyl)-2-methyl-3,3a,4,5-tetrahydrobenzo[g]indazole[no description available]medium10tetralins
6-hydroxy-4-methyl-2-phenyl-2,3-dihydropyridazin-3-one[no description available]medium10pyridazinone
1-(4-chlorophenyl)-3-[4-methyl-2-(thiophen-2-yl)-1,3-thiazol-5-yl]urea[no description available]medium101,3-thiazoles;
monochlorobenzenes;
phenylureas;
thiophenes
N'-[(4-chlorophenyl)-oxomethyl]-2-methyl-4-thiazolecarbohydrazide[no description available]medium10carbonyl compound;
organohalogen compound
bi-78d3[no description available]medium10aryl sulfide
n-(3-chloro-4-methylphenyl)-4-methyl-1,2,3-thiadiazole-5-carboxamide[no description available]medium10anilide fungicide;
monocarboxylic acid amide;
monochlorobenzenes;
organosulfur compound;
thiadiazoles		antifungal agrochemical
N'2-[3-(trifluoromethyl)benzoyl]-3-aminopyrazine-2-carbohydrazide[no description available]medium10(trifluoromethyl)benzenes
2-amino-4-(2-chlorophenyl)-6-[(4-chlorophenyl)thio]pyridine-3,5-dicarbonitrile[no description available]medium10phenylpyridine
2-[5-[(3-chlorophenyl)thio]-2-thiophenyl]pyridine[no description available]medium10aryl sulfide
8-methylsulfinyl-4,5-dihydrothieno[3,4-g][2,1]benzoxazole-6-carboxylic acid ethyl ester[no description available]medium10thiophenecarboxylic acid
1-(5-tert-butyl-2-methyl-3-pyrazolyl)-3-(3,5-dichlorophenyl)urea[no description available]medium10ureas
4-[[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]methyl]morpholine[no description available]medium10isoquinolines
7-chloro-3-hydroxy-2-[3-(trifluoromethyl)phenyl]-4-quinazolinone[no description available]medium10quinazolines
2-(1H-benzimidazol-2-ylthio)-1-[2,5-dimethyl-1-(2-oxolanylmethyl)-3-pyrrolyl]ethanone[no description available]medium10benzimidazoles
ethyl 4-(3-oxo-2,3-dihydroisothiazol-2-yl)benzoate[no description available]medium10organic molecular entity
7-chloro-N-(phenylmethyl)-4-quinolinamine[no description available]medium10aminoquinoline
6-methoxy-2-methyl-N-[[3-(trifluoromethyl)phenyl]methyl]-4-quinolinamine[no description available]medium10aminoquinoline
2-acetylpyridine thiosemicarbazone[no description available]medium10
1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea[no description available]medium10
4-(4-chlorophenyl)-3-methylbut-3-en-2-oxime[no description available]medium10
cephalexin[no description available]medium10beta-lactam antibiotic allergen;
cephalosporin;
semisynthetic derivative		antibacterial drug
glycine[no description available]medium10alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
7-aminodesacetoxycephalosporanic acid[no description available]medium10cephalosporin;
monocarboxylic acid
cephalosporin c[no description available]medium10cephalosporinfungal metabolite
phenylglycinamide[no description available]medium10
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Polio0low10
Epidemic Acute Poliomyelitis0low10
Infantile Paralysis0low10
Infections, Plasmodium0low10
Malaria0low10
Marsh Fever0low10
Paludism0low10
Plasmodium Infections0low10
Polio0low10
Polio Encephalitis0low10
Poliomyelitis0low10
Poliomyelitis Infection0low10
Poliomyelitis, Acute0low10
Poliomyelitis, Nonpoliovirus0low10
Poliomyelitis, Preparalytic0low10
Remittent Fever0low10
Sensitivity and Specificity0low10