Compounds > 2-aminoperimidine
Page last updated: 2024-11-07

2-aminoperimidine

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Description

2-aminoperimidine: inhibits bacterial NhaA Na/H+ antiporters; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID112416
CHEMBL ID311074
SCHEMBL ID315396
MeSH IDM0294967

Synonyms (17)

Synonym
CHEMBL311074 ,
2-aminoperimidine
einecs 249-264-0
perimidine, 2-amino-
aminoperimidine
1h-perimidin-2-amine
bdbm50010751
1h,3h-perimidin-2-ylideneamine
28832-64-6
SCHEMBL315396
DTXSID1067419
UNDUSVBXIVZGOQ-UHFFFAOYSA-N
CCG-256329
2,5-dichlorosulfanilicacid
Q27452326
GLXC-26983
iitr00693
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Na(+)/H(+) antiporter NhaAEscherichia coli K-12IC50 (µMol)1.42860.80001.42862.3000AID385945; AID385946; AID385947; AID385953; AID385955; AID385956; AID385957
Transient receptor potential cation channel subfamily A member 1Rattus norvegicus (Norway rat)IC50 (µMol)2.30000.45003.42437.5000AID385946
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (7)

Processvia Protein(s)Taxonomy
sodium ion transportNa(+)/H(+) antiporter NhaAEscherichia coli K-12
regulation of pHNa(+)/H(+) antiporter NhaAEscherichia coli K-12
response to salt stressNa(+)/H(+) antiporter NhaAEscherichia coli K-12
response to alkaline pHNa(+)/H(+) antiporter NhaAEscherichia coli K-12
sodium ion transmembrane transportNa(+)/H(+) antiporter NhaAEscherichia coli K-12
regulation of intracellular pHNa(+)/H(+) antiporter NhaAEscherichia coli K-12
transmembrane transportNa(+)/H(+) antiporter NhaAEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (4)

Processvia Protein(s)Taxonomy
sodium ion transmembrane transporter activityNa(+)/H(+) antiporter NhaAEscherichia coli K-12
antiporter activityNa(+)/H(+) antiporter NhaAEscherichia coli K-12
sodium:proton antiporter activityNa(+)/H(+) antiporter NhaAEscherichia coli K-12
cardiolipin bindingNa(+)/H(+) antiporter NhaAEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (2)

Processvia Protein(s)Taxonomy
plasma membraneNa(+)/H(+) antiporter NhaAEscherichia coli K-12
membraneNa(+)/H(+) antiporter NhaAEscherichia coli K-12
plasma membraneNa(+)/H(+) antiporter NhaAEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (23)

Assay IDTitleYearJournalArticle
AID385948Antiporter activity in Escherichia coli K12 wild type EcNhaA N64C mutant assessed as effect on lithium chloride-induced pH changes by acridine orange fluorescence assay2007The Journal of biological chemistry, Dec-28, Volume: 282, Issue:52
Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications.
AID385952Antiporter activity in Escherichia coli K12 wild type EcNhaA F72C mutant assessed as effect on sodium chloride-induced pH changes by acridine orange fluorescence assay2007The Journal of biological chemistry, Dec-28, Volume: 282, Issue:52
Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications.
AID385951Antiporter activity in Escherichia coli K12 wild type EcNhaA F72C mutant assessed as effect on lithium chloride-induced pH changes by acridine orange fluorescence assay2007The Journal of biological chemistry, Dec-28, Volume: 282, Issue:52
Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications.
AID385959Antiporter activity in Escherichia coli K12 wild type EcNhaA N64C mutant assessed as effect on sodium chloride-induced pH changes by acridine orange fluorescence assay2007The Journal of biological chemistry, Dec-28, Volume: 282, Issue:52
Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications.
AID385945Antiporter activity in Escherichia coli K12 wild type EcNhaA H225Q mutant assessed as effect on sodium chloride-induced pH changes by acridine orange fluorescence assay2007The Journal of biological chemistry, Dec-28, Volume: 282, Issue:52
Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications.
AID385950Antiporter activity in Escherichia coli K12 wild type EcNhaA G76C mutant assessed as effect on sodium chloride-induced pH changes by acridine orange fluorescence assay2007The Journal of biological chemistry, Dec-28, Volume: 282, Issue:52
Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications.
AID385960Antiporter activity in Escherichia coli K12 wild type EcNhaA F71C mutant assessed as effect on sodium chloride-induced pH changes by acridine orange fluorescence assay2007The Journal of biological chemistry, Dec-28, Volume: 282, Issue:52
Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications.
AID385949Antiporter activity in Escherichia coli K12 wild type EcNhaA G76C mutant assessed as effect on lithium chloride-induced pH changes by acridine orange fluorescence assay2007The Journal of biological chemistry, Dec-28, Volume: 282, Issue:52
Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications.
AID385955Antiporter activity in Escherichia coli K12 wild type EcNhaA W62C mutant assessed as effect on sodium chloride-induced pH changes by acridine orange fluorescence assay2007The Journal of biological chemistry, Dec-28, Volume: 282, Issue:52
Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications.
AID1640019Luciferase/luciferin-expressing antifolate-resistant parasites were used to infect a culture of HepG2 cells that were pre-incubated with compounds. Infected hepatocytes emit light due to the luciferase reaction. Assay results are presented as the percent 2018Science (New York, N.Y.), 12-07, Volume: 362, Issue:6419
Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.
AID385953Antiporter activity in Escherichia coli K12 wild type EcNhaA F71C mutant assessed as effect on lithium chloride-induced pH changes by acridine orange fluorescence assay2007The Journal of biological chemistry, Dec-28, Volume: 282, Issue:52
Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications.
AID385947Antiporter activity in Escherichia coli K12 wild type EcNhaA H225R mutant assessed as effect on sodium chloride-induced pH changes by acridine orange fluorescence assay2007The Journal of biological chemistry, Dec-28, Volume: 282, Issue:52
Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications.
AID1640018Luciferase/luciferin-expressing antifolate-resistant parasites were used to infect a culture of HepG2 cells that were pre-incubated with compounds. Infected hepatocytes emit light due to the luciferase reaction. Assay results are presented as the percent 2018Science (New York, N.Y.), 12-07, Volume: 362, Issue:6419
Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.
AID385956Antiporter activity in Escherichia coli K12 wild type EcNhaA assessed as effect on lithium chloride-induced pH changes by acridine orange fluorescence assay2007The Journal of biological chemistry, Dec-28, Volume: 282, Issue:52
Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications.
AID385946Antiporter activity in Escherichia coli K12 wild type EcNhaA H225R mutant assessed as effect on lithium chloride-induced pH changes by acridine orange fluorescence assay2007The Journal of biological chemistry, Dec-28, Volume: 282, Issue:52
Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications.
AID156818In vitro inhibitory activity against [3H](+)-MK-801 binding to PCP receptor in guinea pig brain membrane homogenates1990Journal of medicinal chemistry, Sep, Volume: 33, Issue:9
Synthesis and structure-activity relationships of N,N'-di-o-tolylguanidine analogues, high-affinity ligands for the haloperidol-sensitive sigma receptor.
AID385957Antiporter activity in Escherichia coli K12 wild type EcNhaA assessed as effect on sodium chloride-induced pH changes by acridine orange fluorescence assay2007The Journal of biological chemistry, Dec-28, Volume: 282, Issue:52
Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications.
AID204440In vitro inhibitory activity against [3H]-DTG in guinea pig brain membrane homogenates1990Journal of medicinal chemistry, Sep, Volume: 33, Issue:9
Synthesis and structure-activity relationships of N,N'-di-o-tolylguanidine analogues, high-affinity ligands for the haloperidol-sensitive sigma receptor.
AID385958Antiporter activity in Escherichia coli K12 wild type EcNhaA H225Q mutant assessed as effect on lithium chloride-induced pH changes by acridine orange fluorescence assay2007The Journal of biological chemistry, Dec-28, Volume: 282, Issue:52
Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications.
AID385954Antiporter activity in Escherichia coli K12 wild type EcNhaA W62C mutant assessed as effect on lithium chloride-induced pH changes by acridine orange fluorescence assay2007The Journal of biological chemistry, Dec-28, Volume: 282, Issue:52
Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (18.18)18.2507
2000's4 (36.36)29.6817
2010's3 (27.27)24.3611
2020's2 (18.18)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.22

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.22 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.71 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.22)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chlorine
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.		1.9910halide anion;
monoatomic chlorine		cofactor;
Escherichia coli metabolite;
human metabolite
acridone
acridone : A member of the class of acridines that is 9,10-dihydroacridine substituted by an oxo group at position 9.		2.1710acridines;
cyclic ketone
ethacridine
Ethacridine: A topically applied anti-infective agent.		2.1710acridines
amiodarone
Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.. amiodarone : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.		2.17101-benzofurans;
aromatic ketone;
organoiodine compound;
tertiary amino compound		cardiovascular drug
ym 58483
[no description available]		2.1710
camphor, (+-)-isomer
[no description available]		2.1710bornane monoterpenoid;
cyclic monoterpene ketone		plant metabolite
carbonyl cyanide m-chlorophenyl hydrazone
Carbonyl Cyanide m-Chlorophenyl Hydrazone: A proton ionophore. It is commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes.. CCCP : A member of the class of monochlorobenzenes that is benzene substituted by 2-(1,3-dinitrilopropan-2-ylidene)hydrazinyl and chloro groups at positions 1 and 3, respectively. It is a mitochondrial depolarizing agent that induces reactive oxygen species mediated cell death.		2.1710hydrazone;
monochlorobenzenes;
nitrile		antibacterial agent;
geroprotector;
ionophore
carbonyl cyanide p-trifluoromethoxyphenylhydrazone
Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone: A proton ionophore that is commonly used as an uncoupling agent in biochemical studies.. carbonyl cyanide p-trifluoromethoxyphenylhydrazone : A hydrazone that is hydrazonomalononitrile in which one of the hydrazine hydrogens is substituted by a p-trifluoromethoxyphenyl group.		2.1710aromatic ether;
hydrazone;
nitrile;
organofluorine compound		ATP synthase inhibitor;
geroprotector;
ionophore
papaverine
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.. papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.		2.1710benzylisoquinoline alkaloid;
dimethoxybenzene;
isoquinolines		antispasmodic drug;
vasodilator agent
pimobendan
pimobendan: produces arterial & venous dilatation in dogs; structure given in first source		2.1710benzimidazoles;
pyridazinone		cardiotonic drug;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
vasodilator agent
terfenadine
Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.		2.1710diarylmethane
1,3-ditolylguanidine
1,3-ditolylguanidine: structure given in first source; a selective ligand for the sigma binding sites in the brain		1.9710toluenes
n-isopropyl-n-phenyl-4-phenylenediamine
N-isopropyl-N'-phenyl-p-phenylenediamine : The N-substituted diamine that is 1,4-phenylenediamine substituted at one N with an isopropyl group and at the other with a phenyl group.		2.1710N-substituted diamineallergen;
antioxidant
diphenylguanidine
diphenylguanidine: vulcanization accelerator; RN given refers to parent cpd. 1,3-diphenylguanidine : Guanidine carrying a phenyl substituent on each of the two amino groups. It is used as an accelerator in the rubber industry.		1.9710guanidinesallergen
3-amino-9-ethylcarbazole
3-amino-9-ethylcarbazole: RN given refers to parent cpd		2.1710carbazoles
cycloguanil
cycloguanil: the active metabolite of proguanil; antifolate drug; structure in first source. cycloguanil : A triazine in which a 1,6-dihydro-1,3,5-triazine ring is substituted at N-1 by a 4-chlorophenyl group, at C-2 and -4 by amino groups and at C-6 by gem-dimethyl groups. A dihydrofolate reductase inhibitor, it is a metabolite of the antimalarial drug proguanil.		2.1710triazinesantifolate;
antiinfective agent;
antimalarial;
antiparasitic agent;
antiprotozoal drug;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor
quinazolines
Quinazolines: A group of aromatic heterocyclic compounds that contain a bicyclic structure with two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring.. quinazoline : A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.. quinazolines : Any organic heterobicyclic compound based on a quinazoline skeleton and its substituted derivatives.		3.1250azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinazolines
2,4,6-trichlorophenyl 4-nitrophenyl ether
2,4,6-trichlorophenyl 4-nitrophenyl ether: structure		2.1710aromatic ether;
C-nitro compound;
chlorobenzenes		EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide
amiloride
Amiloride: A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705). amiloride : A member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid.		2.4120aromatic amine;
guanidines;
organochlorine compound;
pyrazines		diuretic;
sodium channel blocker
2-phenylthiazolidine-4-carboxylic acid
2-phenylthiazolidine-4-carboxylic acid: RN given refers to cpd without isomeric designation		2.1710
benz(cd)indol-2(1h)-one
benz(cd)indol-2(1H)-one: structure in first source		2.1710
tetraphenylcyclopentadienone
tetraphenylcyclopentadienone: singlet oxygen trapping agent		2.1710stilbenoid
3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine
[no description available]		2.17101,2,4-triazines
honokiol
[no description available]		2.1710biphenyls
bathophenanthroline
4,7-diphenyl-1,10-phenanthroline : A member of the class of phenanthrolines that is 1,10-phenanthroline bearing two phenyl substituents at positions 4 and 7.		2.1710benzenes;
phenanthrolines		chelator
2-phenyl-4,5-dichloro-3-pyridazinone
[no description available]		2.1710
n-benzylmaleimide
[no description available]		2.1710
phenylglycine nitrile
phenylglycine nitrile: structure in first source		2.1710
4,5-dimethyl-1,2-phenylenediamine
4,5-dimethyl-1,2-phenylenediamine: RN given refers to parent cpd		2.1710
mmv665852
MMV665852: an antischistosomal agent		2.1710
n-(2-methoxyphenyl)maleimide
N-(2-methoxyphenyl)maleimide: structure given in first source		2.1710
1,3-bis(3-chlorophenyl)urea
[no description available]		2.1710ureas
2-phenyl-4-oxohydroquinoline
2-phenyl-4-oxohydroquinoline: structure given in first source		2.1710
2-chloro-3-(4-methylanilino)naphthalene-1,4-dione
[no description available]		2.17101,4-naphthoquinones
mequindox
Mequindox: a synthetic quinoxaline 1,4-dioxide derivative which can effectively improve growth and feed efficiency in animals; structure in first source		2.1710
1,3-bis(3,5-dichlorophenyl)urea
1,3-bis(3,5-dichlorophenyl)urea: COH - City of Hope; has antineoplastic activity		2.1710
dienestrol
Dienestrol: A synthetic, non-steroidal estrogen structurally related to stilbestrol. It is used, usually as the cream, in the treatment of menopausal and postmenopausal symptoms.. dienestrol : An olefinic compound that is hexa-2,4-diene substituted by 4-hydroxyphenyl groups at positions 3 and 4 respectively.		2.1710
cinnamoylglycine
cinnamoylglycine: structure given in first source. N-cinnamoylglycine : An N-acylglycine in which the acyl group is specified as (2E)-3-phenylprop-2-enoyl (cinnamoyl).		2.1710N-acylglycinemetabolite
4-(4-ethoxyphenyl)-4-oxobutanoic acid
[no description available]		2.1710aromatic ketone
3-(4-chlorophenyl)-5-propyl-1H-pyrazolo[1,5-a]pyrimidin-7-one
[no description available]		2.1710pyrazoles;
ring assembly
N-[4-[methyl(phenyl)sulfamoyl]phenyl]-2-thiophenecarboxamide
[no description available]		2.1710aromatic amide
4-chloro-N-[3-cyano-4-(phenylthio)phenyl]benzamide
[no description available]		2.1710benzamides
3-(4-morpholinyl)-4-(2-pyridinyl)-N-[3-(trifluoromethyl)phenyl]-1-pyrazolecarboxamide
[no description available]		2.1710pyrazolopyridine
7-chloro-2-methyl-4-(4-methylphenyl)sulfonylthiazolo[5,4-b]indole
[no description available]		2.1710sulfonamide
4-[2-[(2,6-dimethoxyphenyl)-oxomethoxy]-1-oxoethyl]-2,5-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
[no description available]		2.1710methoxybenzoic acid
2-(1H-benzimidazol-2-ylthio)-1-(2,5-dimethyl-1-prop-2-enyl-3-pyrrolyl)ethanone
[no description available]		2.1710benzimidazoles
2,3-dihydro-1,4-dioxin-5-carboxylic acid [2-[4-[4-(2-methylbutan-2-yl)phenoxy]anilino]-2-oxoethyl] ester
[no description available]		2.1710aromatic ether
2-(1,3-benzoxazol-2-ylthio)-1-(2,5-dimethyl-1-prop-2-enyl-3-pyrrolyl)ethanone
[no description available]		2.1710benzoxazole
3-(4-chlorophenyl)-2-methyl-3,3a,4,5-tetrahydrobenzo[g]indazole
[no description available]		2.1710tetralins
6-hydroxy-4-methyl-2-phenyl-2,3-dihydropyridazin-3-one
[no description available]		2.1710pyridazinone
1-(4-chlorophenyl)-3-[4-methyl-2-(thiophen-2-yl)-1,3-thiazol-5-yl]urea
1-(4-chlorophenyl)-3-[4-methyl-2-(thiophen-2-yl)-1,3-thiazol-5-yl]urea : An member of the class of phenylureas that is urea having 4-chlorophenyl and 4-methyl-2-(thiophen-2-yl)-1,3-thiazol-5-yl groups attached at positions 1 and 3 respectively.		2.17101,3-thiazoles;
monochlorobenzenes;
phenylureas;
thiophenes
N'-[(4-chlorophenyl)-oxomethyl]-2-methyl-4-thiazolecarbohydrazide
[no description available]		2.1710carbonyl compound;
organohalogen compound
bi-78d3
[no description available]		2.1710aryl sulfide
n-(3-chloro-4-methylphenyl)-4-methyl-1,2,3-thiadiazole-5-carboxamide
N-(3-chloro-4-methylphenyl)-4-methyl-1,2,3-thiadiazole-5-carboxamide: activates the plant defense response; structure in first source. tiadinil : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-methyl-1,2,3-thiadiazole-5-carboxylic acid with the amino group of 3-chloro-4-methylaniline. It is a fungicide used particularly for the control of fungal diseases in rice.		2.1710anilide fungicide;
monocarboxylic acid amide;
monochlorobenzenes;
organosulfur compound;
thiadiazoles		antifungal agrochemical
N'2-[3-(trifluoromethyl)benzoyl]-3-aminopyrazine-2-carbohydrazide
[no description available]		2.1710(trifluoromethyl)benzenes
2-amino-4-(2-chlorophenyl)-6-[(4-chlorophenyl)thio]pyridine-3,5-dicarbonitrile
[no description available]		2.1710phenylpyridine
2-[5-[(3-chlorophenyl)thio]-2-thiophenyl]pyridine
[no description available]		2.1710aryl sulfide
8-methylsulfinyl-4,5-dihydrothieno[3,4-g][2,1]benzoxazole-6-carboxylic acid ethyl ester
[no description available]		2.1710thiophenecarboxylic acid
1-(5-tert-butyl-2-methyl-3-pyrazolyl)-3-(3,5-dichlorophenyl)urea
[no description available]		2.1710ureas
4-[[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]methyl]morpholine
[no description available]		2.1710isoquinolines
7-chloro-3-hydroxy-2-[3-(trifluoromethyl)phenyl]-4-quinazolinone
[no description available]		2.1710quinazolines
2-(1H-benzimidazol-2-ylthio)-1-[2,5-dimethyl-1-(2-oxolanylmethyl)-3-pyrrolyl]ethanone
[no description available]		2.1710benzimidazoles
ethyl 4-(3-oxo-2,3-dihydroisothiazol-2-yl)benzoate
[no description available]		2.1710organic molecular entity
7-chloro-N-(phenylmethyl)-4-quinolinamine
[no description available]		2.1710aminoquinoline
6-methoxy-2-methyl-N-[[3-(trifluoromethyl)phenyl]methyl]-4-quinolinamine
[no description available]		2.1710aminoquinoline
2-acetylpyridine thiosemicarbazone
2-acetylpyridine thiosemicarbazone: RN given refers to parent cpd		2.1710
1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea
1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea: structure in first source		2.1710
4-(4-chlorophenyl)-3-methylbut-3-en-2-oxime
4-(4-chlorophenyl)-3-methylbut-3-en-2-oxime: a TRPA1 antagonist		2.1710
ConditionIndicatedRelationship StrengthStudiesTrials
Plasmodium falciparum Malaria
[description not available]		02.110
Malaria, Falciparum
Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.		02.110
Anemia, Fanconi
[description not available]		02.1310
Fanconi Anemia
Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)		02.1310
Infections, Plasmodium
[description not available]		02.1710
Malaria
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.		02.1710