Page last updated: 2024-10-24

neurotransmitter receptor transport to plasma membrane

Definition

Target type: biologicalprocess

The directed movement of neurotransmitter receptor to the plasma membrane in transport vesicles. [GOC:dos]

Neurotransmitter receptor transport to the plasma membrane is a complex and tightly regulated process that ensures the proper localization and function of these crucial signaling molecules. The journey begins in the endoplasmic reticulum (ER), where newly synthesized receptors undergo folding and quality control. Once correctly folded, they are trafficked to the Golgi apparatus, where they may be further modified and sorted into transport vesicles. These vesicles bud off from the Golgi and travel to the plasma membrane, where they fuse and release their cargo, the receptors, into the extracellular space.

The transport of receptors is not a passive process; it is actively regulated by a variety of molecular players, including adaptor proteins, chaperones, and motor proteins. Adaptor proteins bind to specific signals on the receptor and link them to other proteins involved in vesicle formation and transport. Chaperones ensure that the receptor maintains its proper conformation and prevent aggregation. Motor proteins use energy derived from ATP hydrolysis to move vesicles along microtubule tracks, facilitating their journey to the plasma membrane.

The final step in the process involves the fusion of the transport vesicle with the plasma membrane, releasing the receptors into the extracellular space. This fusion event is mediated by specialized proteins called SNAREs, which interact with each other to promote membrane fusion.

The precise mechanism of neurotransmitter receptor transport to the plasma membrane varies depending on the specific receptor type and the cell type in which it is expressed. However, the general principles outlined above hold true for most receptors, ensuring their proper localization and function in neuronal communication.'
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Proteins (1)

ProteinDefinitionTaxonomy
Excitatory amino acid transporter 3An excitatory amino acid transporter 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P43005]Homo sapiens (human)

Compounds (13)

CompoundDefinitionClassesRoles
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acidalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.non-proteinogenic alpha-amino acid
cysteinecysteine;
cysteine zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
serine family amino acid
EC 4.3.1.3 (histidine ammonia-lyase) inhibitor;
flour treatment agent;
human metabolite
aspartic acidaspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent

Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.

L-aspartic acid : The L-enantiomer of aspartic acid.
aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid
Escherichia coli metabolite;
mouse metabolite;
neurotransmitter
glutamic acidglutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.

Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid
Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
sym 2081
dihydrokainatedicarboxylic acid
serine o-sulfateL-serine O-sulfate : A non-proteinogenic L-alpha-amino acid that is the O-sulfo derivative of L-serine.

serine O-sulfate: RN given refers to (L)-isomer
L-serine derivative;
non-proteinogenic L-alpha-amino acid;
O-sulfoamino acid
hinokininhinokinin : A lignan that is dihydrofuran-2(3H)-one (gamma-butyrolactone) substituted by a 3,4-methylenedioxybenzyl group at positions 3 and 4 (the 3R,4R-diastereoisomer).

hinokinin: suppresses expression of both HBsAg and HBeAg
benzodioxoles;
gamma-lactone;
lignan
trypanocidal drug
3-hydroxyaspartic acid, (threo-l)-isomer(3S)-3-hydroxy-L-aspartic acid : The (3S)-diastereomer of 3-hydroxy-L-aspartic acid.3-hydroxy-L-aspartic acidmetabolite
2-amino-3-phenylmethoxybutanedioic acidaspartic acid derivative
dl-threo-beta-benzyloxyaspartate
l-beta-threo-benzyl-aspartateL-beta-threo-benzyl-aspartate: structure in first source
ucph 1012-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile: structure in first source