| Assay ID | Title | Year | Journal | Article |
|---|
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID109339 | Antagonist activity against Metabotropic glutamate receptor 4 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation | 1997 | Journal of medicinal chemistry, Sep-12, Volume: 40, Issue:19
| Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. |
| AID108986 | Ratio between the measured EC50 and the glutamate EC50 measured against Metabotropic glutamate receptor 2; No effect | 1999 | Journal of medicinal chemistry, May-06, Volume: 42, Issue:9
| Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors: a different environment but similar recognition of an extended glutamate conformation. |
| AID108989 | Inhibitory activity against Metabotropic glutamate receptor 2 in the rat HEK 293 cells. | 1999 | Journal of medicinal chemistry, May-06, Volume: 42, Issue:9
| Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors: a different environment but similar recognition of an extended glutamate conformation. |
| AID108673 | Agonist activity against Metabotropic glutamate receptor 2 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation; No effect at 1 mM | 1997 | Journal of medicinal chemistry, Sep-12, Volume: 40, Issue:19
| Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. |
| AID109327 | Agonist activity against Metabotropic glutamate receptor 4 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation; No effect at 1 mM | 1997 | Journal of medicinal chemistry, Sep-12, Volume: 40, Issue:19
| Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. |
| AID108356 | Agonist activity against Metabotropic glutamate receptor 1 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation; No effect at 1 mM | 1997 | Journal of medicinal chemistry, Sep-12, Volume: 40, Issue:19
| Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. |
| AID108487 | Antagonist activity against Metabotropic glutamate receptor 1 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation | 1997 | Journal of medicinal chemistry, Sep-12, Volume: 40, Issue:19
| Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. |
| AID108514 | Inhibitory activity against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells. | 1999 | Journal of medicinal chemistry, May-06, Volume: 42, Issue:9
| Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors: a different environment but similar recognition of an extended glutamate conformation. |
| AID108507 | Ratio between the measured EC50 and the glutamate EC50 measured against Metabotropic glutamate receptor 1; No effect | 1999 | Journal of medicinal chemistry, May-06, Volume: 42, Issue:9
| Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors: a different environment but similar recognition of an extended glutamate conformation. |
| AID108826 | Antagonist activity against Metabotropic glutamate receptor 2 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation | 1997 | Journal of medicinal chemistry, Sep-12, Volume: 40, Issue:19
| Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. |
| AID476363 | Agonist activity at rat mGlu6 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular inositol phosphate accumulation after 1 hr by scintillation counting | 2010 | Journal of medicinal chemistry, Apr-08, Volume: 53, Issue:7
| A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists. |
| AID476367 | Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular inositol phosphate accumulation after 1 hr by scintillation counting | 2010 | Journal of medicinal chemistry, Apr-08, Volume: 53, Issue:7
| A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists. |
| AID1455164 | Selectivity ratio of EC50 for mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulation to EC50 for mGlu4 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i prote | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
| Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites. |
| AID271020 | Activity at rat mGluR6 receptor measured as intracellular calcium concentration in HEK293 cells | 2006 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 16, Issue:18
| Design and synthesis of APTCs (aminopyrrolidinetricarboxylic acids): identification of a new group III metabotropic glutamate receptor selective agonist. |
| AID108655 | Potency at Metabotropic glutamate receptor 1, measured as the ratio of EC50 to IC50; No effect at 1 mM | 2002 | Journal of medicinal chemistry, Jul-18, Volume: 45, Issue:15
| Common and selective molecular determinants involved in metabotopic glutamate receptor agonist activity. |
| AID109480 | Potency at Metabotropic glutamate receptor 4, measured as the ratio of EC50 to IC50 | 2002 | Journal of medicinal chemistry, Jul-18, Volume: 45, Issue:15
| Common and selective molecular determinants involved in metabotopic glutamate receptor agonist activity. |
| AID271021 | Activity at rat mGluR7 receptor measured as intracellular calcium concentration in HEK293 cells | 2006 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 16, Issue:18
| Design and synthesis of APTCs (aminopyrrolidinetricarboxylic acids): identification of a new group III metabotropic glutamate receptor selective agonist. |
| AID1455158 | Agonist activity at mGlu6 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulation after 30 mins by scintillation and luminescence counting method | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
| Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites. |
| AID271019 | Activity at rat mGluR5 receptor measured as intracellular calcium concentration in HEK293 cells | 2006 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 16, Issue:18
| Design and synthesis of APTCs (aminopyrrolidinetricarboxylic acids): identification of a new group III metabotropic glutamate receptor selective agonist. |
| AID1455155 | Agonist activity at mGlu8 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulation after 30 mins by scintillation and luminescence counting method | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
| Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites. |
| AID476365 | Agonist activity at rat mGlu7 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular inositol phosphate accumulation after 1 hr by scintillation counting | 2010 | Journal of medicinal chemistry, Apr-08, Volume: 53, Issue:7
| A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists. |
| AID108827 | Antagonist activity against Metabotropic glutamate receptor 2 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation; No effect at 1 mM | 1997 | Journal of medicinal chemistry, Sep-12, Volume: 40, Issue:19
| Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. |
| AID246695 | Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Active | 2005 | Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7
| Virtual screening workflow development guided by the "receiver operating characteristic" curve approach. Application to high-throughput docking on metabotropic glutamate receptor subtype 4. |
| AID109326 | Agonist activity against Metabotropic glutamate receptor 4 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation | 1997 | Journal of medicinal chemistry, Sep-12, Volume: 40, Issue:19
| Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. |
| AID271022 | Activity at rat mGluR8 receptor measured as intracellular calcium concentration in HEK293 cells | 2006 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 16, Issue:18
| Design and synthesis of APTCs (aminopyrrolidinetricarboxylic acids): identification of a new group III metabotropic glutamate receptor selective agonist. |
| AID476357 | Agonist activity at rat mGlu4 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular inositol phosphate accumulation after 1 hr by scintillation counting | 2010 | Journal of medicinal chemistry, Apr-08, Volume: 53, Issue:7
| A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists. |
| AID1455157 | Agonist activity at mGlu4 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulation after 30 mins by scintillation and luminescence counting method | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
| Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites. |
| AID271018 | Activity at rat mGluR4 receptor measured as intracellular calcium concentration in HEK293 cells | 2006 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 16, Issue:18
| Design and synthesis of APTCs (aminopyrrolidinetricarboxylic acids): identification of a new group III metabotropic glutamate receptor selective agonist. |
| AID271028 | Activity at rat mGluR3 receptor measured as intracellular calcium concentration in HEK293 cells | 2006 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 16, Issue:18
| Design and synthesis of APTCs (aminopyrrolidinetricarboxylic acids): identification of a new group III metabotropic glutamate receptor selective agonist. |
| AID109331 | Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian cells by GTPgammaS binding assay | 2000 | Bioorganic & medicinal chemistry letters, Jul-03, Volume: 10, Issue:13
| Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III. |
| AID1455159 | Agonist activity at mGlu7 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulation after 30 mins by scintillation and luminescence counting method | 2018 | Journal of medicinal chemistry, 03-08, Volume: 61, Issue:5
| Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites. |
| AID271017 | Activity at rat mGluR2 receptor measured as intracellular calcium concentration in HEK293 cells | 2006 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 16, Issue:18
| Design and synthesis of APTCs (aminopyrrolidinetricarboxylic acids): identification of a new group III metabotropic glutamate receptor selective agonist. |
| AID109009 | Potency at Metabotropic glutamate receptor 2, measured as the ratio of EC50 to IC50; No effect at 1 mM | 2002 | Journal of medicinal chemistry, Jul-18, Volume: 45, Issue:15
| Common and selective molecular determinants involved in metabotopic glutamate receptor agonist activity. |
| AID1346251 | Rat mGlu8 receptor (Metabotropic glutamate receptors) | 2000 | European journal of pharmacology, Apr-07, Volume: 394, Issue:1
| Pharmacological characterization of the rat metabotropic glutamate receptor type 8a revealed strong similarities and slight differences with the type 4a receptor. |
| AID1346283 | Rat mGlu4 receptor (Metabotropic glutamate receptors) | 1997 | Journal of medicinal chemistry, Sep-12, Volume: 40, Issue:19
| Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |