Target type: molecularfunction
Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine. [EC:1.5.1.34]
6,7-dihydropteridine reductase activity catalyzes the NADPH-dependent reduction of 7,8-dihydrobiopterin to tetrahydrobiopterin. This enzyme plays a crucial role in the biosynthesis of tetrahydrobiopterin, a cofactor essential for several enzymatic reactions, including the hydroxylation of phenylalanine to tyrosine by phenylalanine hydroxylase, the hydroxylation of tyrosine to dopa by tyrosine hydroxylase, and the oxidation of tryptophan to 5-hydroxytryptophan by tryptophan hydroxylase. These reactions are involved in the synthesis of neurotransmitters such as dopamine, norepinephrine, epinephrine, and serotonin. 6,7-dihydropteridine reductase activity also participates in the regeneration of tetrahydrobiopterin from dihydrobiopterin, which is formed during the catalytic cycle of the aforementioned monooxygenases. Mutations in the gene encoding this enzyme can lead to various disorders, including hyperphenylalaninemia, dopa-responsive dystonia, and neurotransmitter deficiencies.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Oxygen-insensitive NAD(P)H nitroreductase | An oxygen-insensitive NAD(P)H nitroreductase that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P38489] | Escherichia coli K-12 |
| Dihydropteridine reductase | A dihydropteridine reductase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P09417] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine : A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease. | methylpyridines; phenylpyridine; tetrahydropyridine | neurotoxin |
| 4-phenylpyridine | phenylpyridine | ||
| 1-methyl-4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine | |||
| 4-phenyl-1,2,3,6-tetrahydropyridine | 4-phenyl-1,2,3,6-tetrahydropyridine: RN given refers to parent cpd | ||
| tretazicar | tretazicar: minor descriptor (75-84); on-line & Index Medicus search AZIRIDINES (75-84) | ||
| sn 23862 | 5-(N,N-bis(2-chloroethyl)amino)-2,4-dinitrobenzamide: RN & structure given in first source | ||
| pr-104a | PR-104A: 3,5-dinitrobenzamide nitrogen mustard, an alkyating antineoplastic; PR-104A is the corresponding alcohol of PR104 |