ainsliadimer a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

ainsliadimer A: a sesquiterpene lactone dimer with an unusual carbon skeleton from Ainsliaea macrocephala; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ainsliadimer A : A sesquiterpene lactone isolated from the whole plants of Ainsliaea macrocephala; exhibits inhibitory activity against production of nitric oxide (NO). [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Flora	Rank	Flora Definition	Family	Family Definition
Ainsliaea	genus	[no description available]	Asteraceae	A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH]

Cross-References

ID Source	ID
PubMed CID	24939147
CHEMBL ID	4877539
CHEBI ID	65376
SCHEMBL ID	17214370
MeSH ID	M0523521

Synonyms (16)

Synonym
ainsliadimer a
(+)-ainsliadimer a
(3as,3a's,6ar,6a'r,7a's,9r,9ar,9bs,10a's,10b's,10c's)-7a',10a'-dihydroxy-3,3',6,6'-tetramethylideneicosahydro-2h-spiro[azuleno[4,5-b]furan-9,8'-cyclopenta[2,3]azuleno[4,5-b]furan]-2,2',8(3h,3'h)-trione
CHEBI:65376
SCHEMBL17214370
Q27133821
ofp6ez7dzu ,
ainsliadimer a [mi]
unii-ofp6ez7dzu
1039431-94-1
(3as,3'as,6ar,6'ar,7'as,8'r,9ar,9bs,10'as,10'bs,10'cs)-eicosahydro-7'a,10'a-dihydroxy-3,3',6,6'-tetrakis(methylene)spiro(azuleno(4,5-b)furan-9(2h),8'-(8h)cyclopent(2,3)azuleno(4,5-b)furan)-2,2',8(3h,3'h)-trione
spiro(azuleno(4,5-b)furan-9(2h),8'-(8h)cyclopent(2,3)azuleno(4,5-b)furan)-2,2',8(3h,3'h)-trione, eicosahydro-7'a,10'a-dihydroxy-3,3',6,6'-tetrakis(methylene)-, (3as,3'as,6ar,6'ar,7'as,8'r,9ar,9bs,10'as,10'bs,10'cs)-
spiro[azuleno[4,5-b]furan-9(2h),8'-[8h]cyclopent[2,3]azuleno[4,5-b]furan]-2,2',8(3h,3'h)-trione, eicosahydro-7'a,10'a-dihydroxy-3,3',6,6'-tetrakis(methylene)-, (3as,3'as,6ar,6'ar,7'as,8'r,9ar,9bs,10'as,10'bs,10'cs)-
CHEMBL4877539
DTXSID001098274
(3as,3'as,6ar,6'ar,7'as,8'r,9ar,9bs,10'as,10'bs,10'cs)-eicosahydro-7'a,10'a-dihydroxy-3,3',6,6'-tetrakis(methylene)spiro[azuleno[4,5-b]furan-9(2h),8'-[8h]cyclopent[2,3]azuleno[4,5-b]furan]-2,2',8(3h,3'h)-trione

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

Role	Description
metabolite	Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
EC 1.14.13.39 (nitric oxide synthase) inhibitor	An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of nitric oxide synthase (EC 1.14.13.39).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

Class	Description
spiro compound	A compound having one atom as the only common member of two rings.
sesquiterpene lactone	Any member of a diverse class of complex, multicyclic phytochemicals showing a variety of skeleton arrangements and bioactivities, and having in common a sesquiterpenoid structure including a lactone ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (5)

Assay ID	Title	Year	Journal	Article
AID1773822	Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Cytotoxic Guaianolide Sesquiterpenoids from
AID1773821	Cytotoxicity against rat C6 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Cytotoxic Guaianolide Sesquiterpenoids from
AID1773823	Cytotoxicity against human HCCLM3 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Cytotoxic Guaianolide Sesquiterpenoids from
AID1773824	Cytotoxicity against human PANC-1 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Cytotoxic Guaianolide Sesquiterpenoids from
AID1773825	Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-Glo assay	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Cytotoxic Guaianolide Sesquiterpenoids from
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (16.67)	29.6817
2010's	3 (50.00)	24.3611
2020's	2 (33.33)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.85

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.85 (24.57)
Research Supply Index	1.95 (2.92)
Research Growth Index	4.80 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.85)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
sesquiterpenes [no description available]	2.99	4	0
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	7.11	1	0	cysteinium	fundamental metabolite

Condition	Relationship Strength	Studies
Colorectal Cancer [description not available]	7.6	1
Colorectal Neoplasms Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.	2.6	1
Benign Neoplasms [description not available]	2.11	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.11	1

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