Page last updated: 2024-10-14

cycloaspeptide a

Description

cycloaspeptide A: isolated from the psychrotolerant fungus Penicillium algidum; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11296670
CHEMBL ID473074
MeSH IDM0484248

Synonyms (17)

Synonym
MEGXM0_000369
smr000440728
MLS000863624
cycloaspeptide a
CHEMBL473074
HMS2270N18
109171-13-3
AKOS030213183
691363-62-9
mfcd08274568
J-002241
cycloaspeptide a_120252
DTXSID001017535
(4s,7s,10s,13s)-10-benzyl-4-[(4-hydroxyphenyl)methyl]-5,11,13-trimethyl-7-(2-methylpropyl)-2,5,8,11,14-pentazabicyclo[14.4.0]icosa-1(20),16,18-triene-3,6,9,12,15-pentone
cycloaspeptidea
CS-0090268
HY-125298
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (9)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency28.18380.177814.390939.8107AID2147
glp-1 receptor, partialHomo sapiens (human)Potency10.00000.01846.806014.1254AID624417
ATAD5 protein, partialHomo sapiens (human)Potency6.51040.004110.890331.5287AID504467
TDP1 proteinHomo sapiens (human)Potency15.47060.000811.382244.6684AID686978; AID686979
67.9K proteinVaccinia virusPotency28.18380.00018.4406100.0000AID720579
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency23.10930.00419.984825.9290AID504444
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency50.11873.548119.542744.6684AID743266
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency70.79460.010323.856763.0957AID2662
gemininHomo sapiens (human)Potency16.36010.004611.374133.4983AID624297
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (25)

Assay IDTitleYearJournalArticle
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID379174Insecticidal activity against 3/4th instar beet armyworm assessed as intoxication and mortality topically dosed at 10 ug/larva after 24 hrs by lepidopteran topical assay2006Journal of natural products, Oct, Volume: 69, Issue:10
Discovery, synthesis, and insecticidal activity of cycloaspeptide E.
AID379182Insecticidal activity against fourth instar beet armyworm assessed as body tremors and partial paralysis after 1 hrs by BAW injection assay2006Journal of natural products, Oct, Volume: 69, Issue:10
Discovery, synthesis, and insecticidal activity of cycloaspeptide E.
AID430991Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay2009Journal of natural products, Jul, Volume: 72, Issue:7
Cycloaspeptides F and G, Cyclic Pentapeptides from a Cordyceps-colonizing isolate of Isaria farinosa.
AID379177Insecticidal activity against beet armyworm assessed as circling dosed by ingestion from leaf after 18 hrs by lepidopteran limited ingestion exposure assay2006Journal of natural products, Oct, Volume: 69, Issue:10
Discovery, synthesis, and insecticidal activity of cycloaspeptide E.
AID430990Cytotoxicity against human HeLa cells after 48 hrs by MTT assay2009Journal of natural products, Jul, Volume: 72, Issue:7
Cycloaspeptides F and G, Cyclic Pentapeptides from a Cordyceps-colonizing isolate of Isaria farinosa.
AID379179Insecticidal activity against cabbage looper assessed as mortality dosed by ingestion from leaf after 24 hrs by lepidopteran limited ingestion exposure assay2006Journal of natural products, Oct, Volume: 69, Issue:10
Discovery, synthesis, and insecticidal activity of cycloaspeptide E.
AID379178Insecticidal activity against cabbage looper assessed as body tremors dosed by ingestion from leaf after 18 hrs by lepidopteran limited ingestion exposure assay2006Journal of natural products, Oct, Volume: 69, Issue:10
Discovery, synthesis, and insecticidal activity of cycloaspeptide E.
AID379172Insecticidal activity against beet armyworm eggs assessed as inhibition of insect growth at 28 degC after 6 days by lepidopteran diet assay2006Journal of natural products, Oct, Volume: 69, Issue:10
Discovery, synthesis, and insecticidal activity of cycloaspeptide E.
AID379176Insecticidal activity against 3/4th instar cabbage looper assessed as intoxication topically dosed at 10 ug/larva after 24 hrs by lepidopteran topical assay2006Journal of natural products, Oct, Volume: 69, Issue:10
Discovery, synthesis, and insecticidal activity of cycloaspeptide E.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (45.45)29.6817
2010's4 (36.36)24.3611
2020's2 (18.18)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]