physodic acid profile

Physodic acid is a lichen-derived secondary metabolite. It has been shown to exhibit a range of biological activities, including antioxidant, anti-inflammatory, and antimicrobial properties. Research on physodic acid focuses on its potential therapeutic applications, particularly in treating inflammatory and infectious diseases. Its unique chemical structure and biological activities make it a promising lead compound for the development of new drugs.'

physodic acid: lichen constituent [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	65751
CHEMBL ID	171637
CHEBI ID	144191
SCHEMBL ID	10383128
MeSH ID	M0126880

Synonym
physodic acid
nsc5916 ,
84-24-2
nsc-5916
physodalin
11h-dibenzo[b,4]dioxepin-7-carboxylic acid, 3,8-dihydroxy-11-oxo-1-(2-oxoheptyl)-6-pentyl-
nsc685589
3,8-dihydroxy-11-oxo-1-(2-oxo-heptyl)-6-pentyl-11h-dibenzo[b,e][1,4]dioxepine-7-carboxylic acid
3,9-dihydroxy-6-oxo-7-(2-oxoheptyl)-1-pentyl-benzo[b][1,4]benzodioxepine-2-carboxylic acid
smr000386934
MLS001049102
nsc-685589
ccris 5524
nsc 5916
3,9-dihydroxy-6-oxo-7-(2-oxoheptyl)-1-pentylbenzo[b][1,4]benzodioxepine-2-carboxylic acid
CHEMBL171637 ,
physodic acid, 5
cid_65751
bdbm50056904
CHEBI:144191
NCGC00246211-01
unii-x901bnt6bf
x901bnt6bf ,
11h-dibenzo(b,e)(1,4)dioxepin-7-carboxylic acid, 3,8-dihydroxy-11-oxo-1-(2-oxoheptyl)-6-pentyl-
HMS2271M06
REGID_FOR_CID_65751
MLS003901469
4,4',6'-trihydroxy-6-(2-oxoheptyl)-2'-pentyl-2,3'-oxydibenzoic acid-.epsilon.-lactone
physodic acid [mi]
3,8-dihydroxy-11-oxo-1-(2-oxoheptyl)-6-pentyl-11h-dibenzo(b,e)(1,4)dioxepin-7-carboxylic acid
DTXSID40232883
SCHEMBL10383128
11h-dibenzo[b,e][1,4]dioxepin-7-carboxylic acid, 3,8-dihydroxy-11-oxo-1-(2-oxoheptyl)-6-pentyl-
3,8-dihydroxy-11-oxo-1-(2-oxoheptyl)-6-pentyl-11h-dibenzo[b,e][1,4]dioxepine-7-carboxylic acid #
KVTYWHGIZSCFLG-UHFFFAOYSA-N
AKOS030492944
3,8-dihydroxy-11-oxo-1-(2-oxoheptyl)-6-pentyl-11h-dibenzo[b,e][1,4]dioxepine-7-carboxylic acid
STL564806
Q27293701

Excerpt	Reference	Relevance
"Physodic acid seemed to inhibit the formation of reactive metabolites, such as N-hydroxy-Trp-P-2, by blocking the hepatic microsomal oxidation systems."	( Inhibitory effect of lichen constituents on mutagenicity induced by heterocyclic amines. Kumon, H; Osawa, T; Reece, CA; Shibamoto, T, 1991)	1

Excerpt	Relevance	Reference
" It was observed that physodic acid showed a dose-response relationship in the range of 12."	( Physodic acid sensitizes LNCaP prostate cancer cells to TRAIL-induced apoptosis. Avola, R; Cardile, V; Graziano, ACE; Madrid, A; Russo, A, 2022)	2.48

Class	Description
carbonyl compound	Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, Putative fructose-1,6-bisphosphate aldolase	Giardia intestinalis	Potency	25.0594	0.1409	11.1940	39.8107	AID2451
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	79.4328	0.6310	35.7641	100.0000	AID504339
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	39.8107	0.1778	14.3909	39.8107	AID2147
Chain A, ATP-DEPENDENT DNA HELICASE Q1	Homo sapiens (human)	Potency	15.8489	0.1259	19.1169	125.8920	AID2549
glp-1 receptor, partial	Homo sapiens (human)	Potency	28.1838	0.0184	6.8060	14.1254	AID624417
WRN	Homo sapiens (human)	Potency	44.6684	0.1683	31.2583	100.0000	AID651768
USP1 protein, partial	Homo sapiens (human)	Potency	50.1187	0.0316	37.5844	354.8130	AID743255
TDP1 protein	Homo sapiens (human)	Potency	30.8678	0.0008	11.3822	44.6684	AID686978; AID686979
Microtubule-associated protein tau	Homo sapiens (human)	Potency	28.1838	0.1800	13.5574	39.8107	AID1460
thioredoxin glutathione reductase	Schistosoma mansoni	Potency	35.4813	0.1000	22.9075	100.0000	AID485364
Smad3	Homo sapiens (human)	Potency	35.4813	0.0052	7.8098	29.0929	AID588855
bromodomain adjacent to zinc finger domain 2B	Homo sapiens (human)	Potency	79.4328	0.7079	36.9043	89.1251	AID504333
Bloom syndrome protein isoform 1	Homo sapiens (human)	Potency	3.9811	0.5406	17.6392	96.1227	AID2528
lysosomal alpha-glucosidase preproprotein	Homo sapiens (human)	Potency	44.6684	0.0366	19.6376	50.1187	AID2100
vitamin D3 receptor isoform VDRA	Homo sapiens (human)	Potency	89.1251	0.3548	28.0659	89.1251	AID504847
DNA polymerase beta	Homo sapiens (human)	Potency	44.6684	0.0224	21.0102	89.1251	AID485314
flap endonuclease 1	Homo sapiens (human)	Potency	22.3872	0.1337	25.4129	89.1251	AID588795
serine/threonine-protein kinase PLK1	Homo sapiens (human)	Potency	23.7781	0.1683	16.4040	67.0158	AID720504
DNA polymerase eta isoform 1	Homo sapiens (human)	Potency	17.7828	0.1000	28.9256	213.3130	AID588591
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	70.7946	0.0501	27.0736	89.1251	AID588590
geminin	Homo sapiens (human)	Potency	1.8356	0.0046	11.3741	33.4983	AID624296
DNA polymerase kappa isoform 1	Homo sapiens (human)	Potency	79.4328	0.0316	22.3146	100.0000	AID588579
Rap guanine nucleotide exchange factor 3	Homo sapiens (human)	Potency	39.8107	6.3096	60.2008	112.2020	AID720709
Rap guanine nucleotide exchange factor 4	Homo sapiens (human)	Potency	15.8489	3.9811	46.7448	112.2020	AID720708
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
envelope glycoprotein	Human immunodeficiency virus 1	IC50 (µMol)	4.1000	2.2000	14.8200	82.2000	AID1986
Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)	IC50 (µMol)	250.0000	0.0010	0.9798	4.5000	AID1799757
Integrase	Human immunodeficiency virus 1	IC50 (µMol)	33.9667	0.0005	1.5443	10.0000	AID93701; AID93703; AID93706
Kinesin-like protein KIF20B	Homo sapiens (human)	IC50 (µMol)	7.6750	4.6000	6.7667	9.9000	AID1320892; AID1320893; AID1320894; AID1320895
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
electroneutral potassium-chloride cotransporter KCC2	Homo sapiens (human)	EC50 (µMol)	8.1900	0.4810	1.5303	2.3100	AID1736
recombinase A	Mycobacterium tuberculosis H37Rv	EC50 (µMol)	5.2390	0.0180	23.2882	287.6000	AID434968; AID435010
streptokinase A precursor	Streptococcus pyogenes M1 GAS	EC50 (µMol)	11.2845	0.0600	8.9128	130.5170	AID1902; AID1914
Estrogen receptor	Rattus norvegicus (Norway rat)	EC50 (µMol)	15.8990	0.0060	22.3670	130.5170	AID1914
Estrogen receptor beta	Rattus norvegicus (Norway rat)	EC50 (µMol)	15.8990	0.0060	22.3670	130.5170	AID1914
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
replicative DNA helicase	Mycobacterium tuberculosis H37Rv	AC50	4.0685	0.0570	30.7482	325.3000	AID449749; AID449750
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
angiogenesis	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
adaptive immune response	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
signal transduction	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathway	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
associative learning	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
Rap protein signal transduction	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
regulation of actin cytoskeleton organization	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
negative regulation of syncytium formation by plasma membrane fusion	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
intracellular signal transduction	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
positive regulation of GTPase activity	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
regulation of angiogenesis	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
positive regulation of angiogenesis	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
positive regulation of protein export from nucleus	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
positive regulation of stress fiber assembly	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
positive regulation of syncytium formation by plasma membrane fusion	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
establishment of endothelial barrier	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
cellular response to cAMP	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
Ras protein signal transduction	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
regulation of insulin secretion	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
MAPK cascade	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
osteoblast differentiation	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
positive regulation of protein phosphorylation	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
response to ischemia	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
apoptotic process	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
signal transduction	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
response to xenobiotic stimulus	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
ovulation cycle process	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
stress-activated protein kinase signaling cascade	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
positive regulation of prostaglandin secretion	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
p38MAPK cascade	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
signal transduction in response to DNA damage	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
positive regulation of apoptotic process	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
positive regulation of MAPK cascade	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
stress-activated MAPK cascade	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
regulation of cell cycle	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
positive regulation of nitric-oxide synthase biosynthetic process	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
cardiac muscle contraction	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
bone development	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
cellular response to sorbitol	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
cellular senescence	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
negative regulation of cold-induced thermogenesis	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
regulation of signal transduction by p53 class mediator	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
mitotic cell cycle	Centromere-associated protein E	Homo sapiens (human)
mitotic spindle organization	Centromere-associated protein E	Homo sapiens (human)
chromosome segregation	Centromere-associated protein E	Homo sapiens (human)
mitotic chromosome movement towards spindle pole	Centromere-associated protein E	Homo sapiens (human)
mitotic metaphase chromosome alignment	Centromere-associated protein E	Homo sapiens (human)
regulation of mitotic metaphase/anaphase transition	Centromere-associated protein E	Homo sapiens (human)
positive regulation of protein kinase activity	Centromere-associated protein E	Homo sapiens (human)
cell division	Centromere-associated protein E	Homo sapiens (human)
metaphase chromosome alignment	Centromere-associated protein E	Homo sapiens (human)
attachment of mitotic spindle microtubules to kinetochore	Centromere-associated protein E	Homo sapiens (human)
kinetochore assembly	Centromere-associated protein E	Homo sapiens (human)
microtubule plus-end directed mitotic chromosome migration	Centromere-associated protein E	Homo sapiens (human)
lateral attachment of mitotic spindle microtubules to kinetochore	Centromere-associated protein E	Homo sapiens (human)
microtubule-based movement	Centromere-associated protein E	Homo sapiens (human)
adaptive immune response	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathway	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
calcium-ion regulated exocytosis	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
regulation of exocytosis	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
insulin secretion	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
positive regulation of insulin secretion	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
regulation of synaptic vesicle cycle	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
Ras protein signal transduction	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
regulation of insulin secretion	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
neural tube closure	Kinesin-like protein KIF20B	Homo sapiens (human)
regulation of mitotic nuclear division	Kinesin-like protein KIF20B	Homo sapiens (human)
positive regulation of cell population proliferation	Kinesin-like protein KIF20B	Homo sapiens (human)
positive regulation of cytokinesis	Kinesin-like protein KIF20B	Homo sapiens (human)
protein localization to microtubule	Kinesin-like protein KIF20B	Homo sapiens (human)
neuron projection morphogenesis	Kinesin-like protein KIF20B	Homo sapiens (human)
cell division	Kinesin-like protein KIF20B	Homo sapiens (human)
regulation of cell cycle	Kinesin-like protein KIF20B	Homo sapiens (human)
positive regulation of intracellular protein transport	Kinesin-like protein KIF20B	Homo sapiens (human)
positive regulation of mitotic cytokinetic process	Kinesin-like protein KIF20B	Homo sapiens (human)
regulation of establishment of cell polarity	Kinesin-like protein KIF20B	Homo sapiens (human)
positive regulation of neuron migration	Kinesin-like protein KIF20B	Homo sapiens (human)
microtubule-based movement	Kinesin-like protein KIF20B	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
guanyl-nucleotide exchange factor activity	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
protein binding	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
protein domain specific binding	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
cAMP binding	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
protein serine/threonine kinase activity	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
MAP kinase kinase activity	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
protein tyrosine kinase activity	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
protein binding	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
ATP binding	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
protein kinase binding	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
protein serine kinase activity	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
microtubule motor activity	Centromere-associated protein E	Homo sapiens (human)
protein binding	Centromere-associated protein E	Homo sapiens (human)
ATP binding	Centromere-associated protein E	Homo sapiens (human)
microtubule binding	Centromere-associated protein E	Homo sapiens (human)
kinetochore binding	Centromere-associated protein E	Homo sapiens (human)
guanyl-nucleotide exchange factor activity	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
protein binding	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
cAMP binding	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
protein-macromolecule adaptor activity	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
small GTPase binding	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
protein binding	Kinesin-like protein KIF20B	Homo sapiens (human)
ATP binding	Kinesin-like protein KIF20B	Homo sapiens (human)
microtubule binding	Kinesin-like protein KIF20B	Homo sapiens (human)
plus-end-directed microtubule motor activity	Kinesin-like protein KIF20B	Homo sapiens (human)
ATP hydrolysis activity	Kinesin-like protein KIF20B	Homo sapiens (human)
protein homodimerization activity	Kinesin-like protein KIF20B	Homo sapiens (human)
WW domain binding	Kinesin-like protein KIF20B	Homo sapiens (human)
microtubule motor activity	Kinesin-like protein KIF20B	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
plasma membrane	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
cortical actin cytoskeleton	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
plasma membrane	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
microvillus	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
endomembrane system	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
membrane	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
lamellipodium	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
filopodium	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
extracellular exosome	Rap guanine nucleotide exchange factor 3	Homo sapiens (human)
cytoplasm	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
cytosol	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
nucleoplasm	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
cytosol	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
cytoskeleton	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
chromosome, centromeric region	Centromere-associated protein E	Homo sapiens (human)
kinetochore	Centromere-associated protein E	Homo sapiens (human)
condensed chromosome, centromeric region	Centromere-associated protein E	Homo sapiens (human)
nucleus	Centromere-associated protein E	Homo sapiens (human)
chromosome	Centromere-associated protein E	Homo sapiens (human)
kinetochore microtubule	Centromere-associated protein E	Homo sapiens (human)
cytosol	Centromere-associated protein E	Homo sapiens (human)
microtubule	Centromere-associated protein E	Homo sapiens (human)
microtubule cytoskeleton	Centromere-associated protein E	Homo sapiens (human)
membrane	Centromere-associated protein E	Homo sapiens (human)
midbody	Centromere-associated protein E	Homo sapiens (human)
intracellular membrane-bounded organelle	Centromere-associated protein E	Homo sapiens (human)
intercellular bridge	Centromere-associated protein E	Homo sapiens (human)
spindle midzone	Centromere-associated protein E	Homo sapiens (human)
mitotic spindle	Centromere-associated protein E	Homo sapiens (human)
mitotic spindle midzone	Centromere-associated protein E	Homo sapiens (human)
microtubule	Centromere-associated protein E	Homo sapiens (human)
cytosol	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
plasma membrane	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
membrane	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
hippocampal mossy fiber to CA3 synapse	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
plasma membrane	Rap guanine nucleotide exchange factor 4	Homo sapiens (human)
nucleus	Kinesin-like protein KIF20B	Homo sapiens (human)
nucleoplasm	Kinesin-like protein KIF20B	Homo sapiens (human)
nucleolus	Kinesin-like protein KIF20B	Homo sapiens (human)
cytoplasm	Kinesin-like protein KIF20B	Homo sapiens (human)
centrosome	Kinesin-like protein KIF20B	Homo sapiens (human)
cytosol	Kinesin-like protein KIF20B	Homo sapiens (human)
growth cone	Kinesin-like protein KIF20B	Homo sapiens (human)
midbody	Kinesin-like protein KIF20B	Homo sapiens (human)
intercellular bridge	Kinesin-like protein KIF20B	Homo sapiens (human)
perinuclear region of cytoplasm	Kinesin-like protein KIF20B	Homo sapiens (human)
spindle midzone	Kinesin-like protein KIF20B	Homo sapiens (human)
contractile ring	Kinesin-like protein KIF20B	Homo sapiens (human)
mitotic spindle pole	Kinesin-like protein KIF20B	Homo sapiens (human)
mitotic spindle midzone	Kinesin-like protein KIF20B	Homo sapiens (human)
microtubule	Kinesin-like protein KIF20B	Homo sapiens (human)
kinesin complex	Kinesin-like protein KIF20B	Homo sapiens (human)
nucleus	Kinesin-like protein KIF20B	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (69)

Assay ID	Title	Year	Journal	Article
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID1320918	Inhibition of basal ATPase activity of human Kif24 at 200 uM by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID336676	Antimicrobial activity against Mycobacterium smegmatis ATCC 607 by agar-dilution streak method	1994	Journal of natural products, Jul, Volume: 57, Issue:7	Alectosarmentin, a new antimicrobial dibenzofuranoid lactol from the lichen, Alectoria sarmentosa.
AID1320902	Cytotoxicity against human BxPC3 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID336679	Antimicrobial activity against Escherichia coli ATCC 9637 at 100 ug/ml by agar-dilution streak method	1994	Journal of natural products, Jul, Volume: 57, Issue:7	Alectosarmentin, a new antimicrobial dibenzofuranoid lactol from the lichen, Alectoria sarmentosa.
AID1320915	Inhibition of basal ATPase activity of human Kif3B at 200 uM by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID91562	Percentage inhibition against strand transfer of HIV-1 integrase at 100 ug/mL	1997	Journal of medicinal chemistry, Mar-14, Volume: 40, Issue:6	Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.
AID1320922	Inhibition of microtubule-stimulated ATPase activity of human MKLP-2 at 200 uM by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320895	Inhibition of microtubule-stimulated ATPase activity of N-terminal His6-tagged/SUMO-fused human MPP1 motor domain (2 to 477 residues) expressed in Escherichia coli BL21 CodonPlus by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320926	Inhibition of microtubule-stimulated ATPase activity of human Kif5A at 200 uM by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320905	Mixed type inhibition of microtubule-stimulated ATPase activity of N-terminal His6-tagged/SUMO-fused human MPP1 motor domain expressed in Escherichia coli BL21 CodonPlus at 1 to 20 uM in presence of ATP by pyruvate kinase/lactate dehydrogenase-linked assa	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID93701	Inhibitory concentration of compound against 3'-processing of HIV-1 integrase in experiment 1&2	1997	Journal of medicinal chemistry, Mar-14, Volume: 40, Issue:6	Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.
AID1320929	Inhibition of microtubule-stimulated ATPase activity of human Kif9 at 200 uM by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320927	Inhibition of microtubule-stimulated ATPase activity of human Kif5C at 200 uM by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320897	Inhibition of basal ATPase activity of N-terminal His6-tagged/SUMO-fused human MPP1 motor domain (2 to 477 residues) expressed in Escherichia coli BL21 CodonPlus in presence of 0.1% Tween-20 by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID336680	Antimicrobial activity against Salmonella gallinarum ATCC 9184 at 100 ug/ml by agar-dilution streak method	1994	Journal of natural products, Jul, Volume: 57, Issue:7	Alectosarmentin, a new antimicrobial dibenzofuranoid lactol from the lichen, Alectoria sarmentosa.
AID93706	Inhibitory concentration of compound against strand transfer of HIV-1 integrase in experiment 1&2	1997	Journal of medicinal chemistry, Mar-14, Volume: 40, Issue:6	Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.
AID336682	Antimicrobial activity against Candida albicans ATCC 10231 at 100 ug/ml by agar-dilution streak method	1994	Journal of natural products, Jul, Volume: 57, Issue:7	Alectosarmentin, a new antimicrobial dibenzofuranoid lactol from the lichen, Alectoria sarmentosa.
AID1320892	Inhibition of basal ATPase activity of N-terminal His6-tagged/SUMO-fused human MPP1 motor domain (57 to 491 residues) expressed in Escherichia coli BL21 CodonPlus by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320941	Half life in human liver microsomes at 3 uM by LC-MS/MS method	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320906	Non-competitive inhibition of ATPase activity of N-terminal His6-tagged/SUMO-fused human MPP1 motor domain expressed in Escherichia coli BL21 CodonPlus at 1 to 20 uM in presence of microtubule by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320904	Inhibition of basal ATPase activity of human Kif15 at 200 uM by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320909	Inhibition of basal ATPase activity of human MKLP-2 at 200 uM by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320933	Solubility of the compound in phosphate buffered saline at pH 6 after 2 hrs by turbidimetric method	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320937	Passive permeability of the compound assessed as compound recovery at 10 uM after 5 hrs by PAMPA	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320931	Inhibition of microtubule-stimulated ATPase activity of human Kif24 at 200 uM by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320934	Solubility of the compound in phosphate buffered saline at pH 7.4 after 2 hrs by turbidimetric method	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320914	Inhibition of basal ATPase activity of human Kif5C at 200 uM by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320920	Inhibition of microtubule-stimulated ATPase activity of human Eg5 at 200 uM by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320899	Cytotoxicity against human J82 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320919	Inhibition of microtubule-stimulated ATPase activity of human Kif15 at 200 uM by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320903	Uncompetitive inhibition of basal ATPase activity of N-terminal His6-tagged/SUMO-fused human MPP1 motor domain expressed in Escherichia coli BL21 CodonPlus at 1 to 20 uM in presence of ATP by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320901	Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320894	Inhibition of basal ATPase activity of N-terminal His6-tagged/SUMO-fused human MPP1 motor domain (2 to 477 residues) expressed in Escherichia coli BL21 CodonPlus by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320893	Inhibition of microtubule-stimulated ATPase activity of N-terminal His6-tagged/SUMO-fused human MPP1 motor domain (57 to 491 residues) expressed in Escherichia coli BL21 CodonPlus by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320935	n-octanol-buffer distribution co-efficient, log D of the compound at pH 7.4 by shake flask method	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320916	Inhibition of basal ATPase activity of human Kif9 at 200 uM by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320921	Inhibition of microtubule-stimulated ATPase activity of human MKLP-1 at 200 uM by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320930	Inhibition of microtubule-stimulated ATPase activity of human Kif4A at 200 uM by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID91561	Percentage inhibition of compound against 3'-processing of HIV-1 integrase at 100 ug/mL	1997	Journal of medicinal chemistry, Mar-14, Volume: 40, Issue:6	Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.
AID336672	Antimicrobial activity against Staphylococcus aureus ATCC 13709 by agar-dilution streak method	1994	Journal of natural products, Jul, Volume: 57, Issue:7	Alectosarmentin, a new antimicrobial dibenzofuranoid lactol from the lichen, Alectoria sarmentosa.
AID336681	Antimicrobial activity against Klebsiella pneumoniae ATCC 10031 at 100 ug/ml by agar-dilution streak method	1994	Journal of natural products, Jul, Volume: 57, Issue:7	Alectosarmentin, a new antimicrobial dibenzofuranoid lactol from the lichen, Alectoria sarmentosa.
AID1320910	Inhibition of basal ATPase activity of human Kif7 at 200 uM by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320917	Inhibition of basal ATPase activity of human Kif4A at 200 uM by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320907	Inhibition of basal ATPase activity of human Eg5 at 200 uM by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320936	Apparent passive permeability of the compound at 10 uM after 5 hrs by PAMPA	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320908	Inhibition of basal ATPase activity of human MKLP-1 at 200 uM by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320925	Inhibition of microtubule-stimulated ATPase activity of human CENP-E by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320912	Inhibition of basal ATPase activity of human CENP-E by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320911	Inhibition of basal ATPase activity of human Kif27 at 200 uM by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320896	Inhibition of basal ATPase activity of N-terminal His6-tagged/SUMO-fused human MPP1 motor domain (57 to 491 residues) expressed in Escherichia coli BL21 CodonPlus in presence of 0.1% Tween-20 by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320900	Cytotoxicity against human UM-UC-3 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320928	Inhibition of microtubule-stimulated ATPase activity of human Kif3B at 200 uM by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320939	Intrinsic clearance in human liver microsomes assessed per mg of protein at 3 uM after 5 to 60 mins by LC-MS/MS method	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320943	Chemical stability of the compound at 5 uM after 15 to 120 mins by LC-MS/MS method	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320913	Inhibition of basal ATPase activity of human Kif5A at 200 uM by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320938	Efflux ratio of apparent permeability across basolateral to apical over apical to basolateral side in human Caco2 cells at 10 uM after 2 hrs by LC-MS/MS method	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320932	Solubility of the compound in phosphate buffered saline at pH 2 after 2 hrs by turbidimetric method	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320940	Intrinsic clearance in mouse liver microsomes assessed per mg of protein at 3 uM after 5 to 60 mins by LC-MS/MS method	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320923	Inhibition of microtubule-stimulated ATPase activity of human Kif7 at 200 uM by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID336678	Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 at 100 ug/ml by agar-dilution streak method	1994	Journal of natural products, Jul, Volume: 57, Issue:7	Alectosarmentin, a new antimicrobial dibenzofuranoid lactol from the lichen, Alectoria sarmentosa.
AID1320924	Inhibition of microtubule-stimulated ATPase activity of human Kif27 at 200 uM by pyruvate kinase/lactate dehydrogenase-linked assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID93703	Inhibitory concentration of compound against disintegration (reversal of strand transfer)of HIV-1 integrase	1997	Journal of medicinal chemistry, Mar-14, Volume: 40, Issue:6	Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.
AID1320898	Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1320942	Half life in mouse liver microsomes at 3 uM by LC-MS/MS method	2016	Journal of natural products, 06-24, Volume: 79, Issue:6	Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis.
AID1799757	Fluorescence Polarization (FP) Assay from Article 10.1016/j.chembiol.2012.05.013: \\Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screening.\\	2012	Chemistry & biology, Jul-27, Volume: 19, Issue:7	Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screening.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (8.00)	18.7374
1990's	4 (16.00)	18.2507
2000's	2 (8.00)	29.6817
2010's	14 (56.00)	24.3611
2020's	3 (12.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	27 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
digallic acid digallic acid: structure given in first source	1.99	1	benzoate ester; gallate ester
3,4-dihydroxybenzohydroxamic acid [no description available]	1.99	1	benzoic acids
procarbazine Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.. procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.	2.13	1	benzamides; hydrazines	antineoplastic agent
usnic acid [no description available]	2.13	1	benzofurans
prednisone Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.. prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.	2.13	1	11-oxo steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	adrenergic agent; anti-inflammatory drug; antineoplastic agent; immunosuppressive agent; prodrug
methylene chloride Methylene Chloride: A chlorinated hydrocarbon that has been used as an inhalation anesthetic and acts as a narcotic in high concentrations. Its primary use is as a solvent in manufacturing and food technology.. dichloromethane : A member of the class of chloromethanes that is methane in which two of the hydrogens have been replaced by chlorine. A dense, non-flammible colourless liquid at room temperature (b.p. 40degreeC, d = 1.33) which is immiscible with water, it is widely used as a solvent, a paint stripper, and for the removal of caffeine from coffee and tea.	2.17	1	chloromethanes; volatile organic compound	carcinogenic agent; polar aprotic solvent; refrigerant
malondialdehyde Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.	1.98	1	dialdehyde	biomarker
psoromic acid psoromic acid: structure in first source	2.73	3	carbonyl compound
manganese Manganese: A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035). manganese(4+) : A manganese cation that is monoatomic and has a formal charge of +4.	2.04	1	elemental manganese; manganese group element atom	Escherichia coli metabolite; micronutrient
1,4,5,8-naphthalenetetracarboxylic acid 1,4,5,8-naphthalenetetracarboxylic acid: structure given in first source	1.99	1
depsidone depsidone: a dibenzo dioxepin with a lactone formed by one of the oxygens and a carbonyl between the two benzyl rings; some derivatives are found in GARCINIA plants. depsidone : The simplest member of the class of depsidones comprising of a heterotricyclic system that is 11H-dibenzo[b,e][1,4]dioxepine substituted by an oxo group at position 11.	7.93	4	depsidones; organic heterotricyclic compound
5,5'-methylenedisalicylic acid 5,5'-methylenedisalicylic acid: inhibits attachment of ribosomes to microsomal membranes; RN given refers to parent cpd; structure in first source & Merck Index, 9th ed, #5934	1.99	1
atranorin atranorin: RN given refers to parent cpd; structure given in first source	2.95	4	carbonyl compound
methyl fluorone black methyl fluorone black: structure	1.99	1
lobaric acid lobaric acid: inhibits formation of leukotrienes C4, D4, and E4; also reduces muscle contraction; structure in first source	2.13	1	carbonyl compound
stictic acid stictic acid: antioxidant from lichen, Usnea articulata; structure in first source	2.42	2	aromatic ether
diffractaic acid difractaic acid: from Lichen, Usnea steineri; active against Gram-positive, multidrug-resistant bacteria; structure in first source	1.99	1	carbonyl compound
3,4,5-trihydroxybenzohydroxamic acid [no description available]	1.99	1
gyrophoric acid gyrophoric acid: a tridepside isolated from Parmelia nepalensis	2.15	1	carbonyl compound
pannarin pannarin: photoirradiation of above cpd leads to its decomposition which is reduced by oxygen. pannarin : A member of the class of depsidones that is 11H-dibenzo[b,e][1,4]dioxepine substituted by methyl groups at positions 1,6 and 9, chloro group at position 2, hydroxy group at position 3, formyl group at position 4, methoxy group at position 8 and an oxo group at position 11. It is a lichen metabolite isolated from several Psoroma species.	1.99	1	aldehyde; aromatic ether; depsidones; organic heterotricyclic compound; organochlorine compound; phenols	antimicrobial agent; antineoplastic agent; apoptosis inducer; lichen metabolite
perlatolinic acid perlatolinic acid: C25-H32-O7; structure in first source	2.13	1	carbonyl compound
benzofurans Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.	2.41	2
(-)-usnic acid (-)-usnic acid : The (-)-enantiomer of usnic acid.	1.98	1	usnic acid	EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor
melphalan Melphalan: An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.. melphalan : A phenylalanine derivative comprising L-phenylalanine having [bis(2-chloroethyl)amino group at the 4-position on the phenyl ring.	2.13	1	L-phenylalanine derivative; nitrogen mustard; non-proteinogenic L-alpha-amino acid; organochlorine compound	alkylating agent; antineoplastic agent; carcinogenic agent; drug allergen; immunosuppressive agent
(+)-usnic acid [no description available]	1.99	1	usnic acid
olivetoric acid olivetoric acid: isolated from Pseudevernia furfuracea; structure in first source	8.13	5	carbonyl compound
chlorogenic acid caffeoylquinic acid: Antiviral Agent; structure in first source. chlorogenate : A monocarboxylic acid anion that is the conjugate base of chlorogenic acid; major species at pH 7.3.	1.99	1	cinnamate ester; tannin	food component; plant metabolite
3-amino-1-methyl-5h-pyrido(4,3-b)indole 3-amino-1-methyl-5H-pyrido(4,3-b)indole: structure	1.97	1	pyridoindole
fumarprotocetraric acid fumarprotocetraric acid: RN given refers to (E)-isomer; structure given in first source	1.99	1	carbonyl compound
salazinic acid salazinic acid: lichen metabolite; structure in first source	2.42	2
4,5-di-O-caffeoylquinic acid [no description available]	1.99	1	quinic acid
8-oxo-2'-deoxyadenosine 8-hydroxy-2'-deoxyadenosine: structure in first source	2.15	1	purine 2'-deoxyribonucleoside
salicylates Salicylates: The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.. hydroxybenzoate : Any benzoate derivative carrying a single carboxylate group and at least one hydroxy substituent.. salicylates : Any salt or ester arising from reaction of the carboxy group of salicylic acid, or any ester resulting from the condensation of the phenolic hydroxy group of salicylic acid with an organic acid.. salicylate : A monohydroxybenzoate that is the conjugate base of salicylic acid.	3.13	5	monohydroxybenzoate	plant metabolite
deoxyguanosine [no description available]	2.55	2	purine 2'-deoxyribonucleoside; purines 2'-deoxy-D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
8-hydroxy-2'-deoxyguanosine 8-Hydroxy-2'-Deoxyguanosine: Common oxidized form of deoxyguanosine in which C-8 position of guanine base has a carbonyl group.. 8-hydroxy-2'-deoxyguanosine : Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage.	2.55	2	guanosines	biomarker

Condition	Relationship Strength	Studies
Cancer of Prostate [description not available]	2.41	1
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	2.41	1
Colorectal Cancer [description not available]	7.17	1
Colorectal Neoplasms Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.	2.17	1
Chromosome-Defective Micronuclei [description not available]	2.08	1
Benign Neoplasms, Brain [description not available]	2.13	1
Astrocytoma, Grade IV [description not available]	2.13	1
Brain Neoplasms Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.	2.13	1
Glioblastoma A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.	2.13	1
Breast Cancer [description not available]	7.13	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.13	1
Central Nervous System Disease [description not available]	2.13	1
Central Nervous System Diseases Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.	2.13	1

physodic acid

Description

Cross-References

Synonyms (39)

Research Excerpts

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Dosage Studied

Drug Classes (1)

Protein Targets (35)

Potency Measurements

Inhibition Measurements

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Biological Processes (73)

Molecular Functions (19)

Ceullar Components (34)

Bioassays (69)

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Studies (25)

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Research Demand Index: 19.51

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physodic acid

Description

Cross-References

Synonyms (39)

Research Excerpts

Actions

Dosage Studied

Drug Classes (1)

Protein Targets (35)

Potency Measurements

Inhibition Measurements

Activation Measurements

Other Measurements

Biological Processes (73)

Molecular Functions (19)

Ceullar Components (34)

Bioassays (69)

Research

Studies (25)

Market Indicators

Research Demand Index: 19.51

Study Types

Related Drugs (35)

Related Conditions (13)