kinetochore microtubule

Definition

Target type: cellularcomponent

Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation. [ISBN:0815316194]

The kinetochore microtubule is a specialized microtubule that connects to the kinetochore, a protein complex assembled on the centromere of a chromosome. It is essential for chromosome segregation during cell division. The kinetochore microtubule is highly dynamic and undergoes cycles of polymerization and depolymerization, which are tightly regulated by a variety of factors. This dynamic behavior allows the microtubule to attach to and detach from the kinetochore, and to pull the chromosome towards the spindle pole. The kinetochore microtubule is also involved in the checkpoint mechanism that ensures that all chromosomes are properly attached to the spindle before the cell enters anaphase. The kinetochore microtubule is composed of a core of α- and β-tubulin heterodimers, which are arranged in a helical structure. The microtubule is anchored to the kinetochore by a number of different proteins, including the Ndc80 complex, the CENP-E protein, and the dynein motor protein. These proteins interact with the microtubule and with the kinetochore to ensure that the microtubule is properly aligned and attached. The kinetochore microtubule is a critical component of the mitotic spindle, and its proper function is essential for accurate chromosome segregation. The kinetochore microtubule is also involved in a variety of other cellular processes, including DNA repair, gene regulation, and cell signaling. The kinetochore microtubule is a fascinating and complex structure that is essential for the proper functioning of eukaryotic cells.'
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Proteins (1)

Compounds (1)