Page last updated: 2024-12-11

liga 20

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

LIGA 20: a semisynthetic GM1 ganglioside with N-dichloroacetylsphingosine; about ten times more potent than the natural GM2 in protecting neurons in culture against glutamate toxicity [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6441213
SCHEMBL ID195718
MeSH IDM0230326

Synonyms (8)

Synonym
liga 20
5-acetamido-2-[5-[3-acetamido-5-hydroxy-6-(hydroxymethyl)-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-2-[6-[(e)-2-[(2,2-dichloroacetyl)amino]-3-hydroxyoctadec-4-enoxy]-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-3-hydroxy-6-(hydroxyme
liga-20
ii3neu5-acggose4-2-d-erythro-1,3-dihydroxy-2-dichloroacetamide-4-trans-octadacene
acetamide, n-(1-(((o-(n-acetyl-alpha-neuraminosyl)-(2-3)-o-(o-beta-d-galactopyranosyl-(1-3)-2-(acetylamino)-2-deoxy-beta-d-galactopyranosyl-(1-4))-o-beta-d-galactopyranosyl-(1-4)-beta-d-glucopyranosyl)oxy)methyl)-2-hydroxy-3-heptadecenyl)-2,2-dichloro-, (
126586-85-4
liga20
SCHEMBL195718

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" The latter group suffered approximately 30% mortality, which increased to approximately 75% at dosage of 30 mg/kg KA, compared with 10-14% for the other two genotypes at the latter dosage."( Enhanced susceptibility to kainate-induced seizures, neuronal apoptosis, and death in mice lacking gangliotetraose gangliosides: protection with LIGA 20, a membrane-permeant analog of GM1.
Ledeen, RW; Lu, ZH; Meyenhofer, MF; Wang, J; Wang, Y; Wu, G; Xie, X, 2005
)
0.53
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (20)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's12 (60.00)18.2507
2000's7 (35.00)29.6817
2010's1 (5.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 89.10

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index89.10 (24.57)
Research Supply Index3.04 (2.92)
Research Growth Index4.17 (4.65)
Search Engine Demand Index154.56 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (89.10)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other20 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]