extracellular matrix protein binding

Definition

Target type: molecularfunction

Binding to a protein that is part of an extracellular matrix. [PMID:22355679]

Extracellular matrix protein binding is a molecular function that involves the interaction of proteins with components of the extracellular matrix (ECM). The ECM is a complex network of macromolecules that provides structural support, regulates cell behavior, and facilitates tissue homeostasis.

Extracellular matrix protein binding is crucial for a wide range of biological processes, including:

* **Cell adhesion and migration:** Cells adhere to the ECM through specific interactions with ECM proteins, such as fibronectin, laminin, and collagen. These interactions provide anchorage and allow cells to move and migrate through tissues.
* **Signal transduction:** ECM proteins can act as signaling molecules, transmitting information from the extracellular environment to the intracellular space. This signaling can influence cell growth, differentiation, and survival.
* **Tissue development and repair:** ECM protein binding plays a critical role in tissue morphogenesis, wound healing, and regeneration.
* **Disease pathogenesis:** Dysregulation of ECM protein binding can contribute to a variety of diseases, including cancer, fibrosis, and arthritis.

The molecular mechanisms underlying ECM protein binding are diverse and involve a combination of electrostatic interactions, hydrogen bonding, hydrophobic interactions, and van der Waals forces. Specific protein domains, such as the integrin-binding domains, collagen-binding domains, and laminin-binding domains, mediate these interactions.

Extracellular matrix protein binding is a highly regulated process, influenced by factors such as cell type, developmental stage, and environmental cues. Understanding the molecular details of ECM protein binding is essential for developing new therapies for a variety of diseases.'
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Proteins (2)

Compounds (35)