integrin alphav-beta5 complex

Definition

Target type: cellularcomponent

An integrin complex that comprises one alphav subunit and one beta5 subunit. [PMID:12297042]

The integrin alphav-beta5 complex is a transmembrane receptor that plays a critical role in cell adhesion, migration, and signaling. It is a heterodimer composed of an alphav subunit and a beta5 subunit, both of which are type I transmembrane proteins. The extracellular domain of the integrin alphav-beta5 complex contains binding sites for a variety of ligands, including extracellular matrix proteins such as vitronectin, fibronectin, and collagen. These interactions mediate cell attachment to the extracellular matrix and are essential for cell survival, growth, and differentiation. The cytoplasmic domain of the integrin alphav-beta5 complex interacts with intracellular signaling molecules, including focal adhesion kinase (FAK) and Src, which activate downstream signaling pathways involved in cell proliferation, survival, and migration. The integrin alphav-beta5 complex is highly expressed in various tissues, including the vascular endothelium, the nervous system, and the immune system. It has been implicated in a number of physiological and pathological processes, including angiogenesis, wound healing, tumor growth, and metastasis. The cellular component of the integrin alphav-beta5 complex is located at the cell membrane, where it forms focal adhesions, which are specialized structures that connect the cell cytoskeleton to the extracellular matrix. These adhesions are dynamic structures that are constantly being assembled and disassembled in response to changes in the cellular environment. They provide a scaffold for the recruitment of signaling molecules and play a crucial role in regulating cell behavior. '
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Proteins (2)

Compounds (22)