integrin alphav-beta8 complex

Definition

Target type: cellularcomponent

An integrin complex that comprises one alphav subunit and one beta8 subunit. [PMID:12297042]

The integrin alphav-beta8 complex is a transmembrane receptor that plays a crucial role in cell adhesion, migration, and signaling. It is a heterodimer composed of two subunits: alphav and beta8. The alphav subunit is a type II transmembrane protein with a large extracellular domain that contains multiple ligand-binding sites. The beta8 subunit is a type I transmembrane protein with a smaller extracellular domain.

The extracellular domains of both alphav and beta8 subunits contribute to the formation of the ligand-binding site, which is located at the interface between the two subunits. This site recognizes and binds to a variety of extracellular matrix (ECM) proteins, including vitronectin, fibronectin, and laminin.

The integrin alphav-beta8 complex is localized to the cell surface, where it interacts with the ECM. This interaction is essential for cell adhesion and migration, as it provides a stable anchor for cells to attach to the surrounding matrix. The complex also plays a role in cell signaling, as it can transduce signals from the ECM into the cell, triggering a variety of intracellular signaling pathways.

Specifically, the cellular component of the integrin alphav-beta8 complex can be described as follows:

- **Plasma membrane:** The integrin alphav-beta8 complex is a transmembrane protein and therefore resides in the plasma membrane. This is the outer boundary of the cell, which separates the cell's interior from the external environment.
- **Focal adhesions:** The integrin alphav-beta8 complex is concentrated in focal adhesions, which are specialized structures that connect the cytoskeleton to the ECM. Focal adhesions are dynamic structures that undergo constant assembly and disassembly in response to changes in cell shape, migration, and adhesion.
- **Cytoskeleton:** The integrin alphav-beta8 complex interacts with the cytoskeleton, which is a network of protein filaments that provide structural support and facilitate cell movement. The complex can bind to cytoskeletal proteins such as actin and talin, linking the ECM to the intracellular environment.
- **Signaling pathways:** The integrin alphav-beta8 complex participates in a variety of signaling pathways, including the focal adhesion kinase (FAK) pathway, the Ras pathway, and the Rho GTPase pathway. These pathways regulate cell adhesion, migration, proliferation, and survival.

Overall, the cellular component of the integrin alphav-beta8 complex encompasses the plasma membrane, focal adhesions, cytoskeleton, and signaling pathways. It plays a crucial role in mediating cell adhesion, migration, and signaling, and its dysfunction can contribute to various disease states.'
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Proteins (1)

Compounds (22)