integrin alphav-beta6 complex

Definition

Target type: cellularcomponent

An integrin complex that comprises one alphav subunit and one beta6 subunit. [PMID:12297042]

The integrin alphav-beta6 complex is a transmembrane protein complex that is primarily localized to the cell surface, specifically within the plasma membrane. It acts as a key adhesion receptor mediating cell-cell and cell-extracellular matrix interactions. The cellular component of this complex can be described as follows:

1. **Plasma membrane:** The integrin alphav-beta6 complex is embedded within the plasma membrane, with its extracellular domains extending outside the cell and its cytoplasmic domains interacting with intracellular signaling molecules.

2. **Focal adhesions:** Integrin alphav-beta6 complexes often cluster at specialized structures called focal adhesions, which are sites of cell-matrix adhesion. These adhesions are dynamic assemblies of proteins that link the cytoskeleton to the extracellular matrix, facilitating cell migration, growth, and differentiation.

3. **Cytoplasm:** The cytoplasmic domains of alphav and beta6 subunits interact with a variety of intracellular signaling molecules. These interactions play a crucial role in mediating downstream signaling pathways, including those involved in cell proliferation, survival, and migration.

4. **Extracellular matrix:** The extracellular domains of alphav and beta6 subunits bind to specific ligands within the extracellular matrix, such as the latent transforming growth factor beta (TGF-beta) and the fibronectin. These interactions are essential for regulating cell behavior and tissue homeostasis.

5. **Other cellular components:** In addition to these primary components, integrin alphav-beta6 complexes may also interact with other cellular structures, including the cytoskeleton, the nucleus, and specific organelles. These interactions contribute to the diverse functions of this complex in various cellular processes.

In summary, the cellular component of the integrin alphav-beta6 complex encompasses the plasma membrane, focal adhesions, cytoplasm, and extracellular matrix. This complex plays a vital role in mediating cell adhesion, signaling, and various cellular processes.'
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Proteins (2)

Compounds (22)