Composite Lymphoma

Two or more distinct types of malignant lymphoid tumors occurring within a single organ or tissue at the same time. It may contain different types of non-Hodgkin lymphoma cells or both Hodgkin and non-Hodgkin lymphoma cells.

Synonyms(1)

Synonym
Composite Lymphoma

Research Excerpts

Overview

Excerpt	Reference
"Composite lymphoma is defined as two or more distinct types of lymphoma in a single anatomical site."	( Fujioka, Y; Fukayama, M; Ichikawa, M; Kamikubo, Y; Kurokawa, M; Nakamura, F; Nannya, Y; Ota, S; Shinozaki, A; Yamamoto, G; Yamazaki, S, 2011)
"Cutaneous composite lymphomas are very rare."	( Hansel, G; Haroske, G; Langner, D; Wollina, U, 2016)
"Composite lymphoma is a rare entity where two or more distinct subtypes of lymphoma coexist within a single organ or tissue."	( Alhoulaiby, S; Alshehabi, Z; Esper, A; Zuhri Yafi, R, 2021)

Research

Studies (11)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	8 (72.73)	28.8240
2020's	3 (27.27)	9.53

Drug	Relationship Strength	Studies
prednisone	low	6
bendamustine hydrochloride	low	1
methotrexate	low	1
cyclin d1	low	2

Protein Targets (159)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
estrogen-related nuclear receptor alpha	3	0	0	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	1	0	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
Chain A, Ferritin light chain	1	0	0	1
acid sphingomyelinase	1	0	0	1
dopamine D1 receptor	1	0	0	1
thioredoxin reductase	1	0	0	1
ClpP	1	0	0	1
15-lipoxygenase, partial	1	0	0	1
phosphopantetheinyl transferase	1	0	0	1
ATAD5 protein, partial	1	0	0	1
USP1 protein, partial	1	0	0	1
TDP1 protein	2	0	0	2
Microtubule-associated protein tau	1	0	0	1
AR protein	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	2	0	0	2
estrogen receptor 2 (ER beta)	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	2	0	0	2
progesterone receptor	2	0	0	2
EWS/FLI fusion protein	1	0	0	1
retinoid X nuclear receptor alpha	1	0	0	1
farnesoid X nuclear receptor	1	0	0	1
estrogen nuclear receptor alpha	2	0	0	2
67.9K protein	1	0	0	1
peroxisome proliferator-activated receptor delta	1	0	0	1
peroxisome proliferator activated receptor gamma	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	2	0	0	2
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
IDH1	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	1	0	0	1
Thymidylate synthase	0	1	0	1
Histone H2A.x	1	0	0	1
Bloom syndrome protein isoform 1	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
chromobox protein homolog 1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
transcriptional regulator ERG isoform 3	1	0	0	1
thyroid hormone receptor beta isoform 2	2	0	0	2
importin subunit beta-1 isoform 1	1	0	0	1
DNA polymerase beta	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
flap endonuclease 1	1	0	0	1
snurportin-1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
geminin	1	0	0	1
DNA polymerase kappa isoform 1	1	0	0	1
peripheral myelin protein 22	1	0	0	1
survival motor neuron protein isoform d	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
lamin isoform A-delta10	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	1
Multidrug resistance-associated protein 4	0	1	0	2
Bile salt export pump	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Voltage-dependent calcium channel gamma-2 subunit	1	0	0	1
Bile salt export pump	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Carbonic anhydrase 2	0	0	1	1
Cellular tumor antigen p53	2	0	0	2
Thymidylate synthase	0	2	0	2
Integrin beta-3	1	0	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Integrin alpha-IIb	1	0	0	1
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Glutamate receptor 2	1	0	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Spike glycoprotein	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
TAR DNA-binding protein 43	1	0	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
ATPase family AAA domain-containing protein 5	1	0	0	1
Ataxin-2	1	0	0	1
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	0	0	1
ATP-dependent phosphofructokinase	1	0	0	1
pregnane X receptor	1	0	0	1
GLI family zinc finger 3	1	0	0	1
thioredoxin glutathione reductase	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
glucocorticoid receptor [Homo sapiens]	1	0	0	1
retinoic acid nuclear receptor alpha variant 1	1	0	0	1
pregnane X nuclear receptor	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	1	0	0	1
nuclear receptor ROR-gamma isoform 1	1	0	0	1
Glucocorticoid receptor	0	2	1	3
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Nuclear receptor ROR-gamma	1	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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