Page last updated: 2024-09-27

Composite Lymphoma

Two or more distinct types of malignant lymphoid tumors occurring within a single organ or tissue at the same time. It may contain different types of non-Hodgkin lymphoma cells or both Hodgkin and non-Hodgkin lymphoma cells.

Synonyms(1)

Synonym
Composite Lymphoma

Research Excerpts

Overview

ExcerptReference
"Composite lymphoma is defined as two or more distinct types of lymphoma in a single anatomical site."( Fujioka, Y; Fukayama, M; Ichikawa, M; Kamikubo, Y; Kurokawa, M; Nakamura, F; Nannya, Y; Ota, S; Shinozaki, A; Yamamoto, G; Yamazaki, S, 2011)
"Cutaneous composite lymphomas are very rare."( Hansel, G; Haroske, G; Langner, D; Wollina, U, 2016)
"Composite lymphoma is a rare entity where two or more distinct subtypes of lymphoma coexist within a single organ or tissue."( Alhoulaiby, S; Alshehabi, Z; Esper, A; Zuhri Yafi, R, 2021)

Research

Studies (11)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's8 (72.73)28.8240
2020's3 (27.27)9.53
DrugIndicatedRelationship StrengthStudiesTrials
prednisone0low60
bendamustine hydrochloride0low10
methotrexate0low10
cyclin d10low20

Protein Targets (159)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
estrogen-related nuclear receptor alpha3003
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase1001
Chain A, Ferritin light chain1001
acid sphingomyelinase1001
dopamine D1 receptor1001
thioredoxin reductase1001
ClpP1001
15-lipoxygenase, partial1001
phosphopantetheinyl transferase1001
ATAD5 protein, partial1001
USP1 protein, partial1001
TDP1 protein2002
Microtubule-associated protein tau1001
AR protein2002
aldehyde dehydrogenase 1 family, member A12002
estrogen receptor 2 (ER beta)2002
nuclear receptor subfamily 1, group I, member 32002
progesterone receptor2002
EWS/FLI fusion protein1001
retinoid X nuclear receptor alpha1001
farnesoid X nuclear receptor1001
estrogen nuclear receptor alpha2002
67.9K protein1001
peroxisome proliferator-activated receptor delta1001
peroxisome proliferator activated receptor gamma1001
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
Thymidylate synthase 0101
alpha-galactosidase1001
IDH11001
euchromatic histone-lysine N-methyltransferase 21001
Thymidylate synthase 0101
Histone H2A.x1001
Bloom syndrome protein isoform 11001
cellular tumor antigen p53 isoform a1001
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
vitamin D3 receptor isoform VDRA2002
chromobox protein homolog 11001
nuclear factor erythroid 2-related factor 2 isoform 22002
transcriptional regulator ERG isoform 31001
thyroid hormone receptor beta isoform 22002
importin subunit beta-1 isoform 11001
DNA polymerase beta1001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
flap endonuclease 11001
snurportin-11001
nuclear factor erythroid 2-related factor 2 isoform 12002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)1001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
geminin1001
DNA polymerase kappa isoform 11001
peripheral myelin protein 221001
survival motor neuron protein isoform d1001
M-phase phosphoprotein 81001
muscleblind-like protein 1 isoform 11001
histone acetyltransferase KAT2A isoform 11001
caspase-1 isoform alpha precursor1001
lamin isoform A-delta101001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30101
Multidrug resistance-associated protein 40102
Bile salt export pump0101
ATP-binding cassette sub-family C member 30102
Voltage-dependent calcium channel gamma-2 subunit1001
Bile salt export pump0101
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Carbonic anhydrase 20011
Cellular tumor antigen p532002
Thymidylate synthase0202
Integrin beta-31001
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
Integrin alpha-IIb1001
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Glutamate receptor 21001
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Spike glycoprotein1001
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
TAR DNA-binding protein 431001
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60001
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 80001
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
Canalicular multispecific organic anion transporter 10101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
ATPase family AAA domain-containing protein 51001
Ataxin-21001
Solute carrier organic anion transporter family member 1B30001
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
Broad substrate specificity ATP-binding cassette transporter ABCG20001
ATP-dependent phosphofructokinase1001
pregnane X receptor1001
GLI family zinc finger 31001
thioredoxin glutathione reductase1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
glucocorticoid receptor [Homo sapiens]1001
retinoic acid nuclear receptor alpha variant 11001
pregnane X nuclear receptor1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a1001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
nuclear receptor ROR-gamma isoform 11001
Glucocorticoid receptor0213
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Nuclear receptor ROR-gamma1001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]