sun and Schizophrenia

sun has been researched along with Schizophrenia* in 1 studies

Other Studies

1 other study(ies) available for sun and Schizophrenia

Article	Year
The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. Bioorganic & medicinal chemistry letters, 2008, Jun-01, Volume: 18, Issue:11 The 'NMDA hypofunction hypothesis of schizophrenia' can be tested in a number of ways. DAO is the enzyme primarily responsible for the metabolism of d-serine, a co-agonist for the NMDA receptor. We identified novel DAO inhibitors, in particular, acid 1, which demonstrated moderate potency for DAO in vitro and ex vivo, and raised plasma d-serine levels after dosing ip to rats. In parallel, analogues were prepared to survey the SARs of 1. Topics: Animals; Carboxylic Acids; Combinatorial Chemistry Techniques; Crystallography, X-Ray; D-Amino-Acid Oxidase; Enzyme Inhibitors; Molecular Conformation; Molecular Structure; Pyrroles; Rats; Schizophrenia; Serine	2008

Article

Year

The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors.

Bioorganic & medicinal chemistry letters, 2008, Jun-01, Volume: 18, Issue:11

The 'NMDA hypofunction hypothesis of schizophrenia' can be tested in a number of ways. DAO is the enzyme primarily responsible for the metabolism of d-serine, a co-agonist for the NMDA receptor. We identified novel DAO inhibitors, in particular, acid 1, which demonstrated moderate potency for DAO in vitro and ex vivo, and raised plasma d-serine levels after dosing ip to rats. In parallel, analogues were prepared to survey the SARs of 1.

Topics: Animals; Carboxylic Acids; Combinatorial Chemistry Techniques; Crystallography, X-Ray; D-Amino-Acid Oxidase; Enzyme Inhibitors; Molecular Conformation; Molecular Structure; Pyrroles; Rats; Schizophrenia; Serine

2008