methallibure and Body-Weight

1. Synergistic action of alpha-chlorohydrin with methallibure (ICI, 33828) on the testicular function of Presbytis entellus entellus Dufresne has been studied. 2. Chronic administration of alpha-chlorohydrin alone (140 mg/day for 40 days) caused testicular lesion resulting in a massive atrophy of the spermatogenic elements. Epididymal epithelium was regressed and the lumen was devoid of spermatozoa. 3. alpha-Chlorohydrin inhibited the synthesis of RNA and sialic acid in the testes and epididymides. Total cholesterol per gram of testis and alkaline phosphatase activity were increased after alpha-chlorohydrin administration. 4. These effects could be achieved with a lower dose of alpha-chlorohydrin (1/4) when administered in combination with a gonadotrophin inhibitor, i. e. ICI, 33828 (Methallibure). Methallibure alone (200 mg/kg: total dose) has no damaging effects on the testes and epididymides. But it altered testicular cholesterol and enzyme activity. 5. In conclusion, an effective inhibition of spermatogenesis could be achieved by synergistic action of the two different drugs i. e. alpha-chlorohydrin and ICI, 33828 (Methallibure).

Topics: Alkaline Phosphatase; alpha-Chlorohydrin; Animals; Body Weight; Chlorohydrins; Cholesterol; Drug Synergism; Epididymis; Haplorhini; Histocytochemistry; Leydig Cells; Male; Methallibure; Organ Size; Seminiferous Tubules; Sialic Acids; Sterilization, Reproductive; Testis; Thiourea

Methallibure administration caused reduction of gonadal weights in female rats and mice indicative of suppression of pituitary gonadotrophins. In the ovaries of the methallibure treated females, there was a great atresia of the follicles and of the corpora lutea. Methalbure caused atrophic changes in the endometrial lining of the vagina. Uterine horns became thin after methallibure treatment. A significant decrease in protein, RNA and sialic acid concentration in uterus and vagina was observed following methallibure treatment. Uterus of treated animals showed decreased glycogen contents. Histological and biochemical changes in the female genital tract of rats and mice suggested that the drug caused antifertility effect due to its possible antiestrogenic action.

Topics: Adrenal Glands; Animals; Body Weight; Female; Genitalia, Female; Methallibure; Mice; Organ Size; Rats; Thiourea

Two groups of five female store pigs, weighing an average of 60 kg at the start of the experiment, were given either 1 or 10 mg metallibure zinc complex (SUISYNCHRON) per kg body weight once daily for six months, in the form of a 2% talcum premix added to concentrates. Clinical inspection, weight gain, haematological findings, blood sugar, serum transaminases, properties of urine and faeces, carcass examination and histological study (internal organs, endocrine glands, skeletal muscle) showed that the 1 mg/kg dosage had no toxic effect. The 10 mg/kg dosage resulted in considerable depression in appetite and some apathy in the pigs, but there was no evidence of a toxic effect.

Topics: Alanine Transaminase; Animals; Appetite; Aspartate Aminotransferases; Blood Cells; Blood Glucose; Body Weight; Dose-Response Relationship, Drug; Erythrocytes; Feces; Female; Hematocrit; Hemoglobins; Hypothalamo-Hypophyseal System; Leukocytes; Long-Term Care; Methallibure; Swine; Thiourea; Urine; Zinc

Metallibure (TURISYNCHRON, VEB Jenapharm, GDR) at 40 mg per kg of food, given for 14 days, completely suppressed laying, and in a shorter time than that produced by conventional methods. Turkeys tolerated TURISYNCHRON well, and no adverse effects were seen. Egg production after TURISYNCHRON treatment was higher than that of untreated controls. This preliminary trial will be followed by more extensive trials.

Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Female; Methallibure; Oviposition; Ovulation; Thiourea; Turkeys

Acute, subacute and chronic toxicity of TURISYNCHRON and its zinc complex (SUISYNCHRON) was tested in mice, rats and dogs. The acute toxicity of SUISYNCHRON was lower than that of TURISYNCHRON in mice and rats. Ulcerative lesions in the duodenum produced by high doses of SUISYNCHRON were quantitatively less pronounced than those produced by similar doses of TURISYNCHRON. Subacute toxicity testing in rats showed that neither preparation had any toxic effect on haematological, clinical chemical or histological criteria in the dosages selected. Chronic toxicity testing of TURISYNCHRON in dogs did not reveal any evidence of toxic damage.

Topics: Acute Disease; Administration, Oral; Animals; Atropine; Body Weight; Chlorpromazine; Chronic Disease; Duodenal Diseases; Female; Injections, Subcutaneous; Lethal Dose 50; Maternal-Fetal Exchange; Methallibure; Mice; Organ Size; Papaverine; Peptic Ulcer; Poisoning; Pregnancy; Rats; Sex Factors; Structure-Activity Relationship; Thiourea; Zinc