Compounds > l-altro-1-deoxynojirimycin
Page last updated: 2024-11-12

l-altro-1-deoxynojirimycin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

L-altro-1-deoxynojirimycin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11105683
CHEMBL ID179409
SCHEMBL ID4619759
MeSH IDM0552157

Synonyms (14)

Synonym
l-altro-1-deoxynojirimycin
(2s,3s,4r,5s)-2-hydroxymethyl-piperidine-3,4,5-triol
bdbm50163445
CHEMBL179409 ,
SCHEMBL4619759
3,4,5-piperidinetriol, 2-(hydroxymethyl)-, (2s,3s,4r,5s)-
188779-13-7
(2s,3s,4r,5s)-2-(hydroxymethyl)piperidin-3,4,5-triol
3,4,5-piperidinetriol, 2-(hydroxymethyl)-, [2s-(2alpha,3beta,4beta,5alpha)]-
(2s,3s,4r,5s)-2-(hydroxymethyl)-3,4,5-piperidinetriol
unii-mc3ukb9vnh
3,4,5-piperidinetriol, 2-(hydroxymethyl)-, (2s-(2alpha,3beta,4beta,5alpha))-
mc3ukb9vnh ,
l-deoxyaltronojirimycin
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (8)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Maltase-glucoamylase, intestinalHomo sapiens (human)IC50 (µMol)1,000.00000.04003.46529.0000AID466668
Lysosomal alpha-glucosidaseHomo sapiens (human)IC50 (µMol)1,000.00000.06002.28897.8000AID466672
Sucrase-isomaltase, intestinalHomo sapiens (human)IC50 (µMol)220.00000.04902.72947.8000AID466667
Glycogen debranching enzymeHomo sapiens (human)IC50 (µMol)100.00008.40009.514310.0000AID466673
Ceramide glucosyltransferaseHomo sapiens (human)IC50 (µMol)100.00000.09000.13250.2000AID466666
Non-lysosomal glucosylceramidaseHomo sapiens (human)IC50 (µMol)100.00000.00030.08970.3000AID466671
Putative alpha-glucosidaseOryza sativa Japonica Group (Japanese rice)IC50 (µMol)450.00000.03000.16670.4200AID240928
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (53)

Processvia Protein(s)Taxonomy
maltose catabolic processMaltase-glucoamylase, intestinalHomo sapiens (human)
starch catabolic processMaltase-glucoamylase, intestinalHomo sapiens (human)
dextrin catabolic processMaltase-glucoamylase, intestinalHomo sapiens (human)
lactose catabolic processLactase-phlorizin hydrolaseHomo sapiens (human)
glycosylceramide catabolic processLactase-phlorizin hydrolaseHomo sapiens (human)
quercetin catabolic processLactase-phlorizin hydrolaseHomo sapiens (human)
cellobiose catabolic processLactase-phlorizin hydrolaseHomo sapiens (human)
maltose metabolic processLysosomal alpha-glucosidaseHomo sapiens (human)
regulation of the force of heart contractionLysosomal alpha-glucosidaseHomo sapiens (human)
diaphragm contractionLysosomal alpha-glucosidaseHomo sapiens (human)
heart morphogenesisLysosomal alpha-glucosidaseHomo sapiens (human)
glycogen catabolic processLysosomal alpha-glucosidaseHomo sapiens (human)
sucrose metabolic processLysosomal alpha-glucosidaseHomo sapiens (human)
glucose metabolic processLysosomal alpha-glucosidaseHomo sapiens (human)
lysosome organizationLysosomal alpha-glucosidaseHomo sapiens (human)
locomotory behaviorLysosomal alpha-glucosidaseHomo sapiens (human)
tissue developmentLysosomal alpha-glucosidaseHomo sapiens (human)
aorta developmentLysosomal alpha-glucosidaseHomo sapiens (human)
vacuolar sequesteringLysosomal alpha-glucosidaseHomo sapiens (human)
muscle cell cellular homeostasisLysosomal alpha-glucosidaseHomo sapiens (human)
neuromuscular process controlling postureLysosomal alpha-glucosidaseHomo sapiens (human)
neuromuscular process controlling balanceLysosomal alpha-glucosidaseHomo sapiens (human)
cardiac muscle contractionLysosomal alpha-glucosidaseHomo sapiens (human)
glycophagyLysosomal alpha-glucosidaseHomo sapiens (human)
sucrose catabolic processSucrase-isomaltase, intestinalHomo sapiens (human)
polysaccharide digestionSucrase-isomaltase, intestinalHomo sapiens (human)
glycogen biosynthetic processGlycogen debranching enzymeHomo sapiens (human)
glycogen catabolic processGlycogen debranching enzymeHomo sapiens (human)
response to nutrientGlycogen debranching enzymeHomo sapiens (human)
response to glucocorticoidGlycogen debranching enzymeHomo sapiens (human)
protein lipidationCeramide glucosyltransferaseHomo sapiens (human)
glucosylceramide biosynthetic processCeramide glucosyltransferaseHomo sapiens (human)
glycosphingolipid biosynthetic processCeramide glucosyltransferaseHomo sapiens (human)
epidermis developmentCeramide glucosyltransferaseHomo sapiens (human)
regulation of signal transductionCeramide glucosyltransferaseHomo sapiens (human)
cell differentiationCeramide glucosyltransferaseHomo sapiens (human)
keratinocyte differentiationCeramide glucosyltransferaseHomo sapiens (human)
leptin-mediated signaling pathwayCeramide glucosyltransferaseHomo sapiens (human)
neuron developmentCeramide glucosyltransferaseHomo sapiens (human)
establishment of skin barrierCeramide glucosyltransferaseHomo sapiens (human)
intestinal lipid absorptionCeramide glucosyltransferaseHomo sapiens (human)
cornified envelope assemblyCeramide glucosyltransferaseHomo sapiens (human)
carbohydrate metabolic processNon-lysosomal glucosylceramidaseHomo sapiens (human)
glucosylceramide catabolic processNon-lysosomal glucosylceramidaseHomo sapiens (human)
cholesterol metabolic processNon-lysosomal glucosylceramidaseHomo sapiens (human)
bile acid metabolic processNon-lysosomal glucosylceramidaseHomo sapiens (human)
glycoside catabolic processNon-lysosomal glucosylceramidaseHomo sapiens (human)
central nervous system neuron developmentNon-lysosomal glucosylceramidaseHomo sapiens (human)
lipid glycosylationNon-lysosomal glucosylceramidaseHomo sapiens (human)
regulation of actin filament polymerizationNon-lysosomal glucosylceramidaseHomo sapiens (human)
regulation of microtubule polymerizationNon-lysosomal glucosylceramidaseHomo sapiens (human)
glycosphingolipid catabolic processNon-lysosomal glucosylceramidaseHomo sapiens (human)
regulation of membrane lipid distributionNon-lysosomal glucosylceramidaseHomo sapiens (human)
central nervous system developmentNon-lysosomal glucosylceramidaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (28)

Processvia Protein(s)Taxonomy
catalytic activityMaltase-glucoamylase, intestinalHomo sapiens (human)
glucan 1,4-alpha-glucosidase activityMaltase-glucoamylase, intestinalHomo sapiens (human)
alpha-1,4-glucosidase activityMaltase-glucoamylase, intestinalHomo sapiens (human)
protein bindingMaltase-glucoamylase, intestinalHomo sapiens (human)
amylase activityMaltase-glucoamylase, intestinalHomo sapiens (human)
carbohydrate bindingMaltase-glucoamylase, intestinalHomo sapiens (human)
maltose alpha-glucosidase activityMaltase-glucoamylase, intestinalHomo sapiens (human)
lactase activityLactase-phlorizin hydrolaseHomo sapiens (human)
galactosylceramidase activityLactase-phlorizin hydrolaseHomo sapiens (human)
glucosylceramidase activityLactase-phlorizin hydrolaseHomo sapiens (human)
beta-glucosidase activityLactase-phlorizin hydrolaseHomo sapiens (human)
glycosylceramidase activityLactase-phlorizin hydrolaseHomo sapiens (human)
protein homodimerization activityLactase-phlorizin hydrolaseHomo sapiens (human)
cellobiose glucosidase activityLactase-phlorizin hydrolaseHomo sapiens (human)
phlorizin hydrolase activityLactase-phlorizin hydrolaseHomo sapiens (human)
alpha-1,4-glucosidase activityLysosomal alpha-glucosidaseHomo sapiens (human)
carbohydrate bindingLysosomal alpha-glucosidaseHomo sapiens (human)
maltose alpha-glucosidase activityLysosomal alpha-glucosidaseHomo sapiens (human)
alpha-glucosidase activityLysosomal alpha-glucosidaseHomo sapiens (human)
oligo-1,6-glucosidase activitySucrase-isomaltase, intestinalHomo sapiens (human)
sucrose alpha-glucosidase activitySucrase-isomaltase, intestinalHomo sapiens (human)
protein bindingSucrase-isomaltase, intestinalHomo sapiens (human)
carbohydrate bindingSucrase-isomaltase, intestinalHomo sapiens (human)
alpha-1,4-glucosidase activitySucrase-isomaltase, intestinalHomo sapiens (human)
glycogen debranching enzyme activityGlycogen debranching enzymeHomo sapiens (human)
4-alpha-glucanotransferase activityGlycogen debranching enzymeHomo sapiens (human)
amylo-alpha-1,6-glucosidase activityGlycogen debranching enzymeHomo sapiens (human)
protein bindingGlycogen debranching enzymeHomo sapiens (human)
polysaccharide bindingGlycogen debranching enzymeHomo sapiens (human)
polyubiquitin modification-dependent protein bindingGlycogen debranching enzymeHomo sapiens (human)
beta-maltose 4-alpha-glucanotransferase activityGlycogen debranching enzymeHomo sapiens (human)
protein bindingCeramide glucosyltransferaseHomo sapiens (human)
ceramide glucosyltransferase activityCeramide glucosyltransferaseHomo sapiens (human)
dihydroceramide glucosyltransferase activityCeramide glucosyltransferaseHomo sapiens (human)
galactosylceramidase activityNon-lysosomal glucosylceramidaseHomo sapiens (human)
glucosylceramidase activityNon-lysosomal glucosylceramidaseHomo sapiens (human)
beta-glucosidase activityNon-lysosomal glucosylceramidaseHomo sapiens (human)
glucosyltransferase activityNon-lysosomal glucosylceramidaseHomo sapiens (human)
steryl-beta-glucosidase activityNon-lysosomal glucosylceramidaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (27)

Processvia Protein(s)Taxonomy
plasma membraneMaltase-glucoamylase, intestinalHomo sapiens (human)
apical plasma membraneMaltase-glucoamylase, intestinalHomo sapiens (human)
extracellular exosomeMaltase-glucoamylase, intestinalHomo sapiens (human)
tertiary granule membraneMaltase-glucoamylase, intestinalHomo sapiens (human)
ficolin-1-rich granule membraneMaltase-glucoamylase, intestinalHomo sapiens (human)
plasma membraneLactase-phlorizin hydrolaseHomo sapiens (human)
external side of apical plasma membraneLactase-phlorizin hydrolaseHomo sapiens (human)
lysosomeLysosomal alpha-glucosidaseHomo sapiens (human)
lysosomal membraneLysosomal alpha-glucosidaseHomo sapiens (human)
plasma membraneLysosomal alpha-glucosidaseHomo sapiens (human)
membraneLysosomal alpha-glucosidaseHomo sapiens (human)
azurophil granule membraneLysosomal alpha-glucosidaseHomo sapiens (human)
lysosomal lumenLysosomal alpha-glucosidaseHomo sapiens (human)
intracellular membrane-bounded organelleLysosomal alpha-glucosidaseHomo sapiens (human)
extracellular exosomeLysosomal alpha-glucosidaseHomo sapiens (human)
tertiary granule membraneLysosomal alpha-glucosidaseHomo sapiens (human)
ficolin-1-rich granule membraneLysosomal alpha-glucosidaseHomo sapiens (human)
autolysosome lumenLysosomal alpha-glucosidaseHomo sapiens (human)
Golgi apparatusSucrase-isomaltase, intestinalHomo sapiens (human)
plasma membraneSucrase-isomaltase, intestinalHomo sapiens (human)
brush borderSucrase-isomaltase, intestinalHomo sapiens (human)
apical plasma membraneSucrase-isomaltase, intestinalHomo sapiens (human)
extracellular exosomeSucrase-isomaltase, intestinalHomo sapiens (human)
extracellular regionGlycogen debranching enzymeHomo sapiens (human)
nucleusGlycogen debranching enzymeHomo sapiens (human)
cytoplasmGlycogen debranching enzymeHomo sapiens (human)
cytosolGlycogen debranching enzymeHomo sapiens (human)
inclusion bodyGlycogen debranching enzymeHomo sapiens (human)
sarcoplasmic reticulumGlycogen debranching enzymeHomo sapiens (human)
secretory granule lumenGlycogen debranching enzymeHomo sapiens (human)
ficolin-1-rich granule lumenGlycogen debranching enzymeHomo sapiens (human)
isoamylase complexGlycogen debranching enzymeHomo sapiens (human)
Golgi membraneCeramide glucosyltransferaseHomo sapiens (human)
membraneCeramide glucosyltransferaseHomo sapiens (human)
Golgi membraneNon-lysosomal glucosylceramidaseHomo sapiens (human)
endoplasmic reticulum membraneNon-lysosomal glucosylceramidaseHomo sapiens (human)
smooth endoplasmic reticulumNon-lysosomal glucosylceramidaseHomo sapiens (human)
cytosolNon-lysosomal glucosylceramidaseHomo sapiens (human)
plasma membraneNon-lysosomal glucosylceramidaseHomo sapiens (human)
membraneNon-lysosomal glucosylceramidaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (19)

Assay IDTitleYearJournalArticle
AID466667Inhibition of sucrase by HPLC2010Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.
AID243641Percent inhibition of rat intestinal maltase at 1000 uM2005Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
Biological properties of D- and L-1-deoxyazasugars.
AID243727Percent inhibition of beta-mannosidase of rat epididymis at 1000 uM2005Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
Biological properties of D- and L-1-deoxyazasugars.
AID466670Inhibition of GBA1 by HPLC2010Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.
AID466669Inhibition of lactase by HPLC2010Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.
AID466672Inhibition of lysosomal alpha-glucosidase by HPLC2010Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.
AID243740Percent inhibition of alpha-mannosidase of rat epididymis 1000 uM2005Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
Biological properties of D- and L-1-deoxyazasugars.
AID466668Inhibition of maltase by HPLC2010Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.
AID466671Inhibition of GBA2 by HPLC2010Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.
AID243746Percent inhibition of beta-galactosidase of rat epididymis at 1000 uM2005Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
Biological properties of D- and L-1-deoxyazasugars.
AID243724Percent inhibition of alpha-galactosidase of coffee bean at 1000 uM2005Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
Biological properties of D- and L-1-deoxyazasugars.
AID243762Percent inhibition of alpha-L-fucosidase of bovine epididymis at 1000 uM2005Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
Biological properties of D- and L-1-deoxyazasugars.
AID466673Inhibition of glycogen glycogen de-branching enzyme by HPLC2010Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.
AID243739Percent inhibition of alpha-mannosidase of jack bean tree at 1000 uM2005Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
Biological properties of D- and L-1-deoxyazasugars.
AID240928Inhibitory concentration against rice alpha-glucosidase2005Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
Biological properties of D- and L-1-deoxyazasugars.
AID243694Percent inhibition of beta-glucosidase of almond tree at 1000 uM2005Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
Biological properties of D- and L-1-deoxyazasugars.
AID243774Percent inhibition of alpha-galactosidase of Aspergillus niger at 1000 uM2005Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
Biological properties of D- and L-1-deoxyazasugars.
AID243726Percent inhibition of beta-galactosidase of bovine liver at 1000 uM2005Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
Biological properties of D- and L-1-deoxyazasugars.
AID466666Inhibition of GCS by cell-based assay2010Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's5 (83.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
1-deoxynojirimycin
1-deoxy-nojirimycin: structure in first source. duvoglustat : An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration.		8.32602-(hydroxymethyl)piperidine-3,4,5-triol;
piperidine alkaloid		anti-HIV agent;
anti-obesity agent;
bacterial metabolite;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
hepatoprotective agent;
hypoglycemic agent;
plant metabolite
miglustat
miglustat: a glucosylceramide synthase inhibitor. miglustat : A hydroxypiperidine that is deoxynojirimycin in which the amino hydrogen is replaced by a butyl group.		2.0510piperidines;
tertiary amino compound		anti-HIV agent;
EC 2.4.1.80 (ceramide glucosyltransferase) inhibitor
1-deoxymannojirimycin
[no description available]		2.0210
deoxyfuconojirimycin
deoxyfuconojirimycin: structure given in first source. deoxyfuconojirimycin : A hydroxypiperidine in which the three hydroxy substituents are located at positions 3, 4 and 5 together with an additional methyl substituent at position 2.		2.0210hydroxypiperidine;
triol		fungal metabolite
proline
Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.. proline : An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2.		2.1110amino acid zwitterion;
glutamine family amino acid;
L-alpha-amino acid;
proline;
proteinogenic amino acid		algal metabolite;
compatible osmolytes;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
migalastat
migalastat: a potent inhibitor of glycolipid biosynthesis		2.9740piperidines
miglitol
[no description available]		2.0510piperidines
n-(5-adamantane-1-yl-methoxy-pentyl)deoxynojirimycin
[no description available]		2.0510
ConditionIndicatedRelationship StrengthStudiesTrials
Obesity
A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).		02.0510