Page last updated: 2024-10-24

amylo-alpha-1,6-glucosidase activity

Definition

Target type: molecularfunction

Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present. [EC:3.2.1.33, ISBN:0198506732]

Amylo-alpha-1,6-glucosidase activity refers to the enzymatic hydrolysis of alpha-1,6-glycosidic linkages in branched polysaccharides, specifically amylopectin and glycogen. This activity is crucial for the breakdown of these complex carbohydrates into smaller, digestible units. The enzyme cleaves the alpha-1,6 glycosidic bonds that connect the branches of the polysaccharide, releasing linear chains of glucose units. This process is essential for the release of glucose from glycogen stores in the liver and muscles, providing energy for cellular processes. The enzyme is involved in various metabolic pathways, including glycogenolysis, starch degradation, and the synthesis of oligosaccharides. Its specific activity depends on the type of polysaccharide substrate, with higher activity observed for amylopectin compared to glycogen. The enzyme plays a vital role in maintaining blood glucose levels, contributing to the regulation of carbohydrate metabolism.'
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Proteins (2)

ProteinDefinitionTaxonomy
Glycogen debranching enzymeA glycogen debranching enzyme that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35573]Homo sapiens (human)
Glycogen debranching enzymeA glycogen debranching enzyme that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35573]Homo sapiens (human)

Compounds (11)

CompoundDefinitionClassesRoles
1-deoxynojirimycin1-deoxy-nojirimycin: structure in first source

duvoglustat : An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration.
2-(hydroxymethyl)piperidine-3,4,5-triol;
piperidine alkaloid
anti-HIV agent;
anti-obesity agent;
bacterial metabolite;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
hepatoprotective agent;
hypoglycemic agent;
plant metabolite
miglustatmiglustat : A hydroxypiperidine that is deoxynojirimycin in which the amino hydrogen is replaced by a butyl group.

miglustat: a glucosylceramide synthase inhibitor
piperidines;
tertiary amino compound
anti-HIV agent;
EC 2.4.1.80 (ceramide glucosyltransferase) inhibitor
2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine: structure given in first sourcedihydroxypyrrolidine
1,4-dideoxy-1,4-iminoarabinitol1,4-dideoxy-1,4-iminoarabinitol: RN given refers to (2S-(2alpha,3beta,4alpha))-isomer; structure given in first source
migalastatmigalastat: a potent inhibitor of glycolipid biosynthesispiperidines
2,5-dideoxy-2,5-imino-d-glucitol2,5-dideoxy-2,5-imino-D-glucitol: structure in first source
1,4-dideoxy-1,4-imino-d-arabinitol
salacinolsalacinol: a sulfated thiosugar from Salacia reticulata (CELASTRACEAE); structure in first source
n-(5-adamantane-1-yl-methoxy-pentyl)deoxynojirimycin
l-altro-1-deoxynojirimycinL-altro-1-deoxynojirimycin: structure in first source
neosalacinol