Target type: biologicalprocess
The chemical reactions and pathways resulting in the breakdown of a cellobiose. [GOC:mengo_curators]
Cellobiose catabolism is a crucial metabolic pathway that breaks down cellobiose, a disaccharide composed of two glucose units linked by a β-1,4-glycosidic bond. This process plays a vital role in the degradation of cellulose, a major structural component of plant cell walls. Cellobiose catabolism occurs in a variety of organisms, including bacteria, fungi, and some animals, and is essential for the utilization of cellulose as an energy source.
The breakdown of cellobiose typically begins with the action of an enzyme called cellobiohydrolase, which hydrolyzes the β-1,4-glycosidic bond, liberating one glucose molecule. The remaining glucose unit is then further metabolized through the glycolytic pathway. Some organisms may use alternative pathways to break down cellobiose, involving enzymes such as cellobiase or cellodextrinase, which may cleave cellobiose at different positions in the molecule.
The catabolism of cellobiose often occurs in conjunction with other metabolic pathways involved in cellulose degradation. For instance, cellulose may first be hydrolyzed to cellobiose by cellulases, and then further metabolized through cellobiose catabolism.
Cellobiose catabolism is tightly regulated to ensure efficient utilization of this important energy source. Factors influencing the activity of cellobiose catabolic enzymes include substrate availability, pH, temperature, and the presence of inhibitors.
In summary, cellobiose catabolism is a critical process for the breakdown of cellulose, releasing glucose that can be further metabolized to generate energy. This process is vital for organisms that utilize cellulose as a source of carbon and energy. '
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Protein | Definition | Taxonomy |
---|---|---|
Lactase-phlorizin hydrolase | A lactase/phlorizin hydrolase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P09848] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
1-deoxynojirimycin | 1-deoxy-nojirimycin: structure in first source duvoglustat : An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration. | 2-(hydroxymethyl)piperidine-3,4,5-triol; piperidine alkaloid | anti-HIV agent; anti-obesity agent; bacterial metabolite; EC 3.2.1.20 (alpha-glucosidase) inhibitor; hepatoprotective agent; hypoglycemic agent; plant metabolite |
miglustat | miglustat : A hydroxypiperidine that is deoxynojirimycin in which the amino hydrogen is replaced by a butyl group. miglustat: a glucosylceramide synthase inhibitor | piperidines; tertiary amino compound | anti-HIV agent; EC 2.4.1.80 (ceramide glucosyltransferase) inhibitor |
migalastat | migalastat: a potent inhibitor of glycolipid biosynthesis | piperidines | |
miglitol | piperidines | ||
n-(5-adamantane-1-yl-methoxy-pentyl)deoxynojirimycin | |||
l-altro-1-deoxynojirimycin | L-altro-1-deoxynojirimycin: structure in first source |