Page last updated: 2024-10-24

cellobiose glucosidase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: D-cellobiose + H2O = 2 D-glucose. [PMID:15604686, RHEA:30679]

Cellobiose glucosidase activity is an enzymatic activity that catalyzes the hydrolysis of cellobiose, a disaccharide composed of two glucose units linked by a beta-1,4-glycosidic bond. The enzyme breaks this bond, releasing two glucose molecules. This reaction is essential in the breakdown of cellulose, a major component of plant cell walls. Cellobiose glucosidases are found in a wide variety of organisms, including bacteria, fungi, and animals. They play a crucial role in the digestion of cellulose, enabling the utilization of this abundant carbohydrate source. The mechanism of cellobiose glucosidase activity involves the enzyme binding to cellobiose and bringing the glycosidic bond into close proximity to an active site containing catalytic residues. These residues, typically acidic amino acids, facilitate the cleavage of the glycosidic bond through a series of steps that may involve protonation, nucleophilic attack, and stabilization of the transition state. The enzyme then releases the two glucose molecules, completing the hydrolysis reaction.'
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Proteins (1)

ProteinDefinitionTaxonomy
Lactase-phlorizin hydrolaseA lactase/phlorizin hydrolase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P09848]Homo sapiens (human)

Compounds (6)

CompoundDefinitionClassesRoles
1-deoxynojirimycin1-deoxy-nojirimycin: structure in first source

duvoglustat : An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration.
2-(hydroxymethyl)piperidine-3,4,5-triol;
piperidine alkaloid
anti-HIV agent;
anti-obesity agent;
bacterial metabolite;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
hepatoprotective agent;
hypoglycemic agent;
plant metabolite
miglustatmiglustat : A hydroxypiperidine that is deoxynojirimycin in which the amino hydrogen is replaced by a butyl group.

miglustat: a glucosylceramide synthase inhibitor
piperidines;
tertiary amino compound
anti-HIV agent;
EC 2.4.1.80 (ceramide glucosyltransferase) inhibitor
migalastatmigalastat: a potent inhibitor of glycolipid biosynthesispiperidines
miglitolpiperidines
n-(5-adamantane-1-yl-methoxy-pentyl)deoxynojirimycin
l-altro-1-deoxynojirimycinL-altro-1-deoxynojirimycin: structure in first source