Target type: molecularfunction
Catalysis of the reaction: D-cellobiose + H2O = 2 D-glucose. [PMID:15604686, RHEA:30679]
Cellobiose glucosidase activity is an enzymatic activity that catalyzes the hydrolysis of cellobiose, a disaccharide composed of two glucose units linked by a beta-1,4-glycosidic bond. The enzyme breaks this bond, releasing two glucose molecules. This reaction is essential in the breakdown of cellulose, a major component of plant cell walls. Cellobiose glucosidases are found in a wide variety of organisms, including bacteria, fungi, and animals. They play a crucial role in the digestion of cellulose, enabling the utilization of this abundant carbohydrate source. The mechanism of cellobiose glucosidase activity involves the enzyme binding to cellobiose and bringing the glycosidic bond into close proximity to an active site containing catalytic residues. These residues, typically acidic amino acids, facilitate the cleavage of the glycosidic bond through a series of steps that may involve protonation, nucleophilic attack, and stabilization of the transition state. The enzyme then releases the two glucose molecules, completing the hydrolysis reaction.'
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Protein | Definition | Taxonomy |
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Lactase-phlorizin hydrolase | A lactase/phlorizin hydrolase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P09848] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
1-deoxynojirimycin | 1-deoxy-nojirimycin: structure in first source duvoglustat : An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration. | 2-(hydroxymethyl)piperidine-3,4,5-triol; piperidine alkaloid | anti-HIV agent; anti-obesity agent; bacterial metabolite; EC 3.2.1.20 (alpha-glucosidase) inhibitor; hepatoprotective agent; hypoglycemic agent; plant metabolite |
miglustat | miglustat : A hydroxypiperidine that is deoxynojirimycin in which the amino hydrogen is replaced by a butyl group. miglustat: a glucosylceramide synthase inhibitor | piperidines; tertiary amino compound | anti-HIV agent; EC 2.4.1.80 (ceramide glucosyltransferase) inhibitor |
migalastat | migalastat: a potent inhibitor of glycolipid biosynthesis | piperidines | |
miglitol | piperidines | ||
n-(5-adamantane-1-yl-methoxy-pentyl)deoxynojirimycin | |||
l-altro-1-deoxynojirimycin | L-altro-1-deoxynojirimycin: structure in first source |