Target type: molecularfunction
Catalysis of the reaction: phlorizin + H2O = beta-D-glucose + phloretin. [PMID:9762914, RHEA:69639]
Phlorizin hydrolase activity refers to the enzymatic hydrolysis of phlorizin, a naturally occurring glycoside found in apple and pear trees. Phlorizin consists of a glucose molecule linked to phloretin, a dihydrochalcone. The enzyme cleaves the glycosidic bond between glucose and phloretin, releasing both components. This activity is specifically associated with the enzyme phlorizin hydrolase, also known as phlorizin glucosidase or phlorizin-beta-glucosidase. The enzyme plays a role in the metabolism of phlorizin and other glycosides, contributing to the breakdown and utilization of these compounds. Phlorizin hydrolase is found in various organisms, including bacteria, fungi, and mammals. In mammals, the enzyme is primarily located in the small intestine, where it contributes to the digestion of dietary phlorizin. Phlorizin hydrolase activity is also important in the context of drug metabolism, as phlorizin can act as an inhibitor of glucose transport. By hydrolyzing phlorizin, the enzyme can modulate the activity of glucose transporters and influence glucose uptake. The study of phlorizin hydrolase activity provides insights into the metabolism of phlorizin and its potential roles in various physiological processes.'
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Protein | Definition | Taxonomy |
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Lactase-phlorizin hydrolase | A lactase/phlorizin hydrolase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P09848] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
1-deoxynojirimycin | 1-deoxy-nojirimycin: structure in first source duvoglustat : An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration. | 2-(hydroxymethyl)piperidine-3,4,5-triol; piperidine alkaloid | anti-HIV agent; anti-obesity agent; bacterial metabolite; EC 3.2.1.20 (alpha-glucosidase) inhibitor; hepatoprotective agent; hypoglycemic agent; plant metabolite |
miglustat | miglustat : A hydroxypiperidine that is deoxynojirimycin in which the amino hydrogen is replaced by a butyl group. miglustat: a glucosylceramide synthase inhibitor | piperidines; tertiary amino compound | anti-HIV agent; EC 2.4.1.80 (ceramide glucosyltransferase) inhibitor |
migalastat | migalastat: a potent inhibitor of glycolipid biosynthesis | piperidines | |
miglitol | piperidines | ||
n-(5-adamantane-1-yl-methoxy-pentyl)deoxynojirimycin | |||
l-altro-1-deoxynojirimycin | L-altro-1-deoxynojirimycin: structure in first source |