Page last updated: 2024-09-27

Thyroid Agenesis

Defective development of the THYROID GLAND. This concept includes thyroid agenesis (aplasia), hypoplasia, or an ectopic gland. Clinical signs usually are those of CONGENITAL HYPOTHYROIDISM.

Synonyms(4)

Synonym
Thyroid, Ectopic
Thyroid Agenesis
Thyroid Hypoplasia
Thyroid Dysgenesis

Research Excerpts

Overview

ExcerptReference
"Bilobar thyroid agenesis is one of rare diseases."( Chen, X; Zhao, S; Zhu, G, 2013)
"Ectopic thyroid is a rare/incidental imaging finding."( Bashir, H; Siddique, M, 2018)
"Thyroid dysgenesis is possibly a polygenic disorder and epigenetic factors could to be implicated in these pathogeneses."( Acosta, AX; Amorim, T; Boa-Sorte, N; Carvalho, G; Cerqueira, TLO; Fernandes, V; Jesus, MS; Ladeia, AMT; Ramos, HE; Ramos, YR; Santos, JG; Silva, TM; Sousa, C; Strappa, GB, 2018)

Research

Studies (81)

TimeframeStudies, This Condition (%)All Conditions %
pre-199011 (13.58)23.3326
1990's0 (0.00)12.5806
2000's7 (8.64)18.1394
2010's49 (60.49)28.8240
2020's14 (17.28)9.53
DrugIndicatedRelationship StrengthStudiesTrials
adenine0low10
iodine0low130
2-propanol0low10
thyroxine0medium461
triiodothyronine0low50
threonine0low10
isoleucine0low10
technetium0low20
iodine0low30
carbimazole0low10
2,2',3,5',6-pentachlorobiphenyl0low10
fluorodeoxyglucose f180low10
perchlorate0low10
propylthiouracil0low10
clove0low10
hes1 protein, human0low10
technetium tc 99m sestamibi0low10
sodium pertechnetate tc 99m0low100
cyclin d10low10
exudates0low10
guanine0low10

Protein Targets (183)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit2002
RAR-related orphan receptor gamma4004
GLI family zinc finger 32002
AR protein3003
aldehyde dehydrogenase 1 family, member A11001
retinoic acid nuclear receptor alpha variant 14004
retinoid X nuclear receptor alpha2002
estrogen nuclear receptor alpha7007
peroxisome proliferator-activated receptor delta3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
activating transcription factor 63003
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Histone H2A.x1001
thyroid hormone receptor beta isoform a3003
heat shock protein beta-12002
nuclear factor erythroid 2-related factor 2 isoform 15005
lamin isoform A-delta106006
Voltage-dependent calcium channel gamma-2 subunit3003
Glutamate receptor 23003
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, MTA/SAH nucleosidase0101
Chain A, Ribosome-inactivating protein alpha-trichosanthin0011
Chain A, Ricin A chain0011
Chain A, Ribosome-inactivating protein 30011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
TDP1 protein4004
nuclear receptor subfamily 1, group I, member 32002
cytochrome P450 family 3 subfamily A polypeptide 44004
glucocorticoid receptor [Homo sapiens]3003
estrogen-related nuclear receptor alpha4004
pregnane X nuclear receptor6006
nuclear factor erythroid 2-related factor 2 isoform 21001
importin subunit beta-1 isoform 11001
snurportin-11001
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 11001
Bile salt export pump0505
Cyclin-dependent kinase 10101
Heat shock protein HSP 90-beta0101
Xanthine dehydrogenase/oxidase0101
TAR DNA-binding protein 431001
Protein mono-ADP-ribosyltransferase PARP150101
Leucine-rich repeat serine/threonine-protein kinase 20202
ATPase family AAA domain-containing protein 51001
Ataxin-21001
acetylcholinesterase3003
cytochrome P450 2D61001
thyroid stimulating hormone receptor1001
thyroid hormone receptor beta isoform 24004
ATP-binding cassette sub-family C member 30202
Multidrug resistance-associated protein 40202
Cellular tumor antigen p534004
5-hydroxytryptamine receptor 2B0112
Spike glycoprotein1001
Canalicular multispecific organic anion transporter 10202
Histamine H3 receptor0101
USP1 protein, partial3003
peroxisome proliferator activated receptor gamma5005
geminin3003
Lactoperoxidase0101
Purine nucleoside phosphorylase0202
Hypoxanthine-guanine phosphoribosyltransferase0001
Ricin0101
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase0011
Purine nucleoside phosphorylase 0012
Shiga toxin subunit A0101
Guanine deaminase0001
Luciferase1001
progesterone receptor2002
aryl hydrocarbon receptor3003
histone deacetylase 9 isoform 31001
Carbonic anhydrase 10202
Carbonic anhydrase 20202
Carbonic anhydrase 40101
Carbonic anhydrase0202
Carbonic anhydrase 150101
Large neutral amino acids transporter small subunit 10101
Proton-coupled amino acid transporter 10101
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
interleukin 81001
phosphopantetheinyl transferase1001
thyroid stimulating hormone receptor1001
EWS/FLI fusion protein2002
vitamin D (1,25- dihydroxyvitamin D3) receptor1001
euchromatic histone-lysine N-methyltransferase 22002
cytochrome P450 2C19 precursor1001
chromobox protein homolog 12002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
NADH-cytochrome b5 reductase 3 0101
Myeloperoxidase0101
Thyroid peroxidase0101
Taste receptor type 2 member 380012
Chain X, Thyroid hormone receptor beta-10022
Chain X, Thyroid hormone receptor beta-10022
thioredoxin reductase1001
apical membrane antigen 1, AMA12002
G1001
serine/threonine-protein kinase PLK11001
DNA polymerase eta isoform 11001
DNA polymerase kappa isoform 11001
Solute carrier organic anion transporter family member 1A40103
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 1A50002
Rap guanine nucleotide exchange factor 31001
Interferon beta1001
HLA class I histocompatibility antigen, B alpha chain 1001
Transthyretin0103
Thyroid hormone receptor alpha0235
Thyroid hormone receptor beta0235
Proliferating cell nuclear antigen0202
Retinoic acid receptor RXR-alpha0022
UDP-glucuronosyltransferase 1A1 0101
Peroxisome proliferator-activated receptor gamma0044
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20002
Solute carrier organic anion transporter family member 1A30002
Solute carrier organic anion transporter family member 4C10102
Monocarboxylate transporter 80001
Inositol hexakisphosphate kinase 11001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Solute carrier organic anion transporter family member 1B10002
cytochrome P450 2C9, partial1001
glp-1 receptor, partial1001
farnesoid X nuclear receptor1001
glucocerebrosidase1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
peripheral myelin protein 221001
muscleblind-like protein 1 isoform 11001
neuropeptide S receptor isoform A1001
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit pi0011
Gamma-aminobutyric acid receptor subunit delta0101
Prothrombin0011
Androgen receptor0101
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-10011
Thyroid hormone receptor beta0101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit delta0011
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-10011
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-40011
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit alpha-60011
Adenosine receptor A10202
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit beta-20011
Gamma-aminobutyric acid receptor subunit epsilon0101
Gamma-aminobutyric acid receptor subunit alpha-60101
Sigma non-opioid intracellular receptor 10011
Solute carrier organic anion transporter family member 4C10001
Gamma-aminobutyric acid receptor subunit gamma-10101
GABA theta subunit0011
Solute carrier organic anion transporter family member 4A10001
Gamma-aminobutyric acid receptor subunit gamma-30101
Solute carrier organic anion transporter family member 1C10101
Gamma-aminobutyric acid receptor subunit epsilon0011
Solute carrier organic anion transporter family member 1B30001
Gamma-aminobutyric acid receptor subunit theta0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]
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