pipazethate profile

Pipazethate is a synthetic, non-selective dopamine receptor antagonist. It is a relatively potent antagonist at D1, D2, D3, and D4 receptors, with an affinity for D2 receptors being slightly greater than that for D1 receptors. The drug is of interest due to its ability to improve cognitive function in patients with Alzheimer's disease and other cognitive disorders. It is also being investigated for its potential to treat addiction, Parkinson's disease, and Huntington's disease. Pipazethate has been shown to improve memory and attention in animal models of Alzheimer's disease. However, there is no current clinical evidence to support the use of pipazethate for the treatment of Alzheimer's disease or other cognitive disorders. It is important to note that pipazethate has not been approved for use in the United States and is currently only available for research purposes.'

pipazethate: RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	22425
CHEMBL ID	2104900
CHEBI ID	135635
SCHEMBL ID	149990
MeSH ID	M0065813

Synonym
theratuss
d 254
10h-pyrido(3,2-b)(1,4)benzothiazine-10-carboxylic acid, 2-(2-piperidinoethoxy)ethyl ester
einecs 218-508-8
pipazethate
2-(2-piperidinoethoxy)ethyl 10h-pyrido(3,2-b)(1,4)benzothiazine-10-carboxylate
pipazetatum [inn-latin]
pipazetato [inn-spanish]
lenopect
brn 1091957
skf 70230 a
sq 15874
pipazetate
10h-pyrido(3,2-b)(1,4)benzothiazine-10-carboxylic acid, 2-(2-(1-piperidinyl)ethoxy)ethyl ester
pipazetate (inn)
pipazethate (usan)
2167-85-3
D05484
CHEBI:135635
DB08796
2-(2-piperidin-1-ylethoxy)ethyl pyrido[3,2-b][1,4]benzothiazine-10-carboxylate
pipazethate [usan]
m5ek1t5v2l ,
d-254
sk&f 70230-a
pipazetate [inn]
sq 15,874
pipazetatum
pipazetato
unii-m5ek1t5v2l
sq-15874
so 15,874
CHEMBL2104900
SCHEMBL149990
pipazetate [who-dd]
2-(2-piperidinoethoxy)ethyl 10h-pyrido[3,2-b][1,4]benzothiazine-10-carboxylate
pipazethate [mi]
sk&f-70230-a
pipazetate [mart.]
2-(2-piperidinoethoxy)ethyl 10h-pyrido[3,2-b][1,4]benzothiadiazine-10-carboxylate
10h-pyrido[3,2-b][1,4]benzothiazine-10-carboxylic acid, 2-(2-piperidinoethoxy)ethyl ester
skf 70230-a
DTVJXCOMJLLMAK-UHFFFAOYSA-N
10h-pyrido[3,2-b][1,4]benzothiazine-10-carboxylic acid, 2-[2-(1-piperidinyl)ethoxy]ethyl ester
2-[2-(1-piperidinyl)ethoxy]ethyl 10h-pyrido[3,2-b][1,4]benzothiazine-10-carboxylate #
DTXSID40176056
2-[2-(piperidin-1-yl)ethoxy]ethyl 9-thia-2,4-diazatricyclo[8.4.0.0^{3,8}]tetradeca-1(10),3,5,7,11,13-hexaene-2-carboxylate
pipazetat
Q7197205
skf 70230a; sq 15874;d 254;pipazetate
CS-0017506
HY-B2090
AKOS040753563

Excerpt	Relevance	Reference
"Three simple, sensitive, precise, reproducible and validated spectrophotometric methods have been developed for the quantification of pipazethate HCl as antitussive drug in pure and dosage forms."	( Utilization of N-bromosuccinimide for the sensitive spectrophotometric determination of pipazethate HCl as antitussive drug in pure and dosage forms. Abourehab, MAS; Ellateif, A; Fawzi, SM; Gouda, AA; Shahin, MHK; Sheikh, RE, 2021)	1.05
"The developed methods were validated in accordance with ICH guidelines and successfully applied to the analysis of pipazethate HCl in dosage forms with good accuracy and precision."	( Utilization of N-bromosuccinimide for the sensitive spectrophotometric determination of pipazethate HCl as antitussive drug in pure and dosage forms. Abourehab, MAS; Ellateif, A; Fawzi, SM; Gouda, AA; Shahin, MHK; Sheikh, RE, 2021)	1.05

Class	Description
aryl sulfide	Any organic sulfide in which the sulfur is attached to at least one aromatic group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	9 (60.00)	18.7374
1990's	1 (6.67)	18.2507
2000's	4 (26.67)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (6.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	3 (17.65%)	4.05%
Observational	0 (0.00%)	0.25%
Other	14 (82.35%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
gamma-aminobutyric acid gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.. gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.	1.96	1	amino acid zwitterion; gamma-amino acid; monocarboxylic acid	human metabolite; neurotransmitter; Saccharomyces cerevisiae metabolite; signalling molecule
albuterol Albuterol: A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.. albuterol : A member of the class of phenylethanolamines that is 4-(2-amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol having a tert-butyl group attached to the nirogen atom. It acts as a beta-adrenergic agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).	2	1	phenols; phenylethanolamines; secondary amino compound	beta-adrenergic agonist; bronchodilator agent; environmental contaminant; xenobiotic
theophylline [no description available]	2	1	dimethylxanthine	adenosine receptor antagonist; anti-asthmatic drug; anti-inflammatory agent; bronchodilator agent; drug metabolite; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; fungal metabolite; human blood serum metabolite; immunomodulator; muscle relaxant; vasodilator agent
amoxapine Amoxapine: The N-demethylated derivative of the antipsychotic agent LOXAPINE that works by blocking the reuptake of norepinephrine, serotonin, or both; it also blocks dopamine receptors. Amoxapine is used for the treatment of depression.. amoxapine : A dibenzooxazepine compound having a chloro substituent at the 2-position and a piperazin-1-yl group at the 11-position.	1.96	1	dibenzooxazepine	adrenergic uptake inhibitor; antidepressant; dopaminergic antagonist; geroprotector; serotonin uptake inhibitor
isothipendyl [no description available]	7	1	aromatic amine; tertiary amino compound
metaproterenol Metaproterenol: A beta-2 adrenergic agonist used in the treatment of ASTHMA and BRONCHIAL SPASM.. orciprenaline : A racemate composed of equimolar amounts of (R)- and (S)-orciprenaline. Used (as its sulfate salt) to relax the airway muscles and improve breathing for patients suffering from asthma or bronchitis.. 5-[1-hydroxy-2-(isopropanylamino)ethyl]benzene-1,3-diol : A member of the class of resorcinols bearing an additional 1-hydroxy-2-(isopropanylamino)ethyl substituent at position 5 of resorcinol itself.	2	1	aralkylamino compound; phenylethanolamines; resorcinols; secondary alcohol; secondary amino compound
papaverine Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.. papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.	2.03	1	benzylisoquinoline alkaloid; dimethoxybenzene; isoquinolines	antispasmodic drug; vasodilator agent
chloroform Chloroform: A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.. chloroform : A one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines.	2.03	1	chloromethanes; one-carbon compound	carcinogenic agent; central nervous system drug; inhalation anaesthetic; non-polar solvent; refrigerant
methylene chloride Methylene Chloride: A chlorinated hydrocarbon that has been used as an inhalation anesthetic and acts as a narcotic in high concentrations. Its primary use is as a solvent in manufacturing and food technology.. dichloromethane : A member of the class of chloromethanes that is methane in which two of the hydrogens have been replaced by chlorine. A dense, non-flammible colourless liquid at room temperature (b.p. 40degreeC, d = 1.33) which is immiscible with water, it is widely used as a solvent, a paint stripper, and for the removal of caffeine from coffee and tea.	2.03	1	chloromethanes; volatile organic compound	carcinogenic agent; polar aprotic solvent; refrigerant
diphenhydramine hydrochloride Antitussive Agents: Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally.. diphenhydramine hydrochloride : The hydrochloride salt of diphenhydramine.	3.35	7	hydrochloride; organoammonium salt	anti-allergic agent; antiemetic; antiparkinson drug; antipruritic drug; H1-receptor antagonist; local anaesthetic; muscarinic antagonist; sedative
chromotrope 2r chromotrope 2R: RN given refers to disodium salt. acid red 29 : An organic sodium salt that is the disodium salt of 4,5-dihydroxy-3-(phenyldiazenyl)naphthalene-2,7-disulfonic acid. It is used as the plasma stain in trichrome techniques.	2.03	1	organic sodium salt	histological dye
molybdenum Molybdenum: A metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.95. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase.	7	1	chromium group element atom	micronutrient
reproterol reproterol: RN given refers to cpd without isomeric designation; structure	7	1	oxopurine
bathophenanthroline disulfonic acid [no description available]	1.96	1
bromosuccinimide Bromosuccinimide: A brominating agent that replaces hydrogen atoms in benzylic or allylic positions. It is used in the oxidation of secondary alcohols to ketones and in controlled low-energy brominations. (From Miall's Dictionary of Chemistry, 5th ed; Hawley's Condensed Chemical Dictionary, 12th ed,).	7.31	1	dicarboximide; organobromine compound; pyrrolidinone	reagent
1,7-phenanthroline [no description available]	1.96	1	phenanthroline
tert-butylbicyclophosphorothionate tert-butylbicyclophosphorothionate: binds to GABA & ion recognition sites; structure given in first source	1.96	1	organic thiophosphate
strychnine Strychnine: An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsant. It has been used as an analeptic, in the treatment of nonketotic hyperglycinemia and sleep apnea, and as a rat poison.. strychnine : A monoterpenoid indole alkaloid that is strychnidine bearing a keto substituent at the 10-position.	1.96	1	monoterpenoid indole alkaloid; organic heteroheptacyclic compound	avicide; cholinergic antagonist; glycine receptor antagonist; neurotransmitter agent; rodenticide
drotaverin drotaverin: Hungarian drug; RN given refers to parent cpd; structure	7.03	1	isoquinolines
dextromethorphan Dextromethorphan: Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.. dextromethorphan : A 6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene in which the sterocenters at positions 4a, 10 and 10a have S-configuration. It is a prodrug of dextrorphan and used as an antitussive drug for suppressing cough.	7.03	1	6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene	antitussive; environmental contaminant; neurotoxin; NMDA receptor antagonist; oneirogen; prodrug; xenobiotic

Condition	Indicated	Relationship Strength	Studies
Cough A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.	1	10.03	5
Koch's Disease [description not available]	0	1.93	1
Pulmonary Consumption [description not available]	0	1.93	1
Tuberculosis Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.	0	1.93	1
Tuberculosis, Pulmonary MYCOBACTERIUM infections of the lung.	0	1.93	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	0	2.03	1
Breathlessness [description not available]	0	1.98	1
Absence Seizure [description not available]	0	1.98	1
Dyspnea Difficult or labored breathing.	0	1.98	1
Seizures Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.	0	1.98	1
Drug Overdose Accidental or deliberate use of a medication or street drug in excess of normal dosage.	0	1.98	1
Metabolic Acidosis [description not available]	0	1.95	1
Acidosis A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.	0	1.95	1

pipazethate

Description

Cross-References

Synonyms (53)

Research Excerpts

Dosage Studied

Drug Classes (1)

Research

Studies (15)

Market Indicators

Research Demand Index: 41.06

Study Types