Compounds > isothipendyl
Page last updated: 2024-11-04

isothipendyl

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Isothipendyl is an antihistamine that is used to treat allergic rhinitis, urticaria, and other allergic conditions. It is a competitive antagonist of histamine at the H1 receptor. Isothipendyl is typically administered orally, but it is also available as a nasal spray and eye drops. The compound was first synthesized in the 1950s and has been studied extensively for its effects on the immune system. Isothipendyl is a relatively safe and effective medication for the treatment of allergic conditions. It is important to note that isothipendyl can cause drowsiness and should not be used by people who operate machinery or drive vehicles.'

Cross-References

ID SourceID
PubMed CID3781
CHEMBL ID2111066
CHEBI ID135183
SCHEMBL ID29234
MeSH IDM0051873

Synonyms (66)

Synonym
n,n,alpha-trimethyl-10h-pyrido(3,2-b)(1,4)benzothiazine-10-ethanamine
isothipendylum [inn-latin]
dimethyl-amino-isopropyl-thiophenyl-pyridyl-amin [german]
brn 0256817
isothipendyl [inn:ban]
einecs 207-578-5
ay 56012
d 201
udantol
10h-pyrido(3,2-b)(1,4)benzothiazine-10-ethanamine, n,n,alpha-trimethyl-
isotipendilo [inn-spanish]
10h-pyrido(3,2-b)(1,4)benzothiazine, 10-(2-(dimethylamino)propyl)-
odantol
10h-pyrido[3,2-b][1,4]benzothiazine-10-ethanamine, n,n,.alpha.-trimethyl-
isothipendyl
DIVK1C_006890
SPECTRUM_001886
SPECTRUM5_001801
KBIO2_002410
KBIO1_001834
KBIO2_007546
KBIOSS_002416
KBIO2_004978
SPECPLUS_000794
CHEBI:135183
DB08802
D08091
482-15-5
isothipendyl (inn)
actapront (tn)
d-201
n,n-dimethyl-1-pyrido[3,2-b][1,4]benzothiazin-10-ylpropan-2-amine
AKOS015962142
isothipendylum
unii-wvz7k9p0jy
isotipendilo
wvz7k9p0jy ,
dimethyl-amino-isopropyl-thiophenyl-pyridyl-amin
ec 207-578-5
actapront
FT-0670563
10-(2-dimethylaminopropyl)-10h-pyrido(3,2-b)(1,4)benzothiazine
dimethylaminoisopropylazaphenothiazine
n-dimethylaminoisopropylthiophenylpyridylamine
isothipendyl [mi]
isothipendyl [inn]
10h-pyrido(3,2-b)(1,4)benzothiazine-10-ethanamine, n,n,.alpha.-trimethyl-
(+/-)-isothipendyl
isothipendyl [who-dd]
ay-56012
SCHEMBL29234
DTXSID5048267
CHEMBL2111066
10h-pyrido[3,2-b][1,4]benzothiazine, 10-[2-(dimethylamino)propyl]-
10-(2-dimethylaminopropyl)-1-azaphenothiazine
10-(2-dimethylaminopropyl)-10h-pyrido[3,2-b][1,4]benzothiazine
OQJBSDFFQWMKBQ-UHFFFAOYSA-N
n,n-dimethyl-1-(10h-pyrido[3,2-b][1,4]benzothiazin-10-yl)-2-propanamine #
10-(2-dimethylaminopropyl)-9-thia-1,10-diazaanthracene
dimethyl(1-{9-thia-2,4-diazatricyclo[8.4.0.0^{3,8}]tetradeca-1(10),3,5,7,11,13-hexaen-2-yl}propan-2-yl)amine
1-(10h-benzo[b]pyrido[2,3-e][1,4]thiazin-10-yl)-n,n-dimethylpropan-2-amine
1330265-10-5
Q928054
ay 56012; d 201; dimethylaminoisopropylazaphenothiazine
CS-0017519
HY-A0178

Research Excerpts

Overview

Isothipendyl chlorhydrate is an azaphenothiazine, the active ingredient of an antipruriginous gel, Apaisyl gel®.

ExcerptReferenceRelevance
"Isothipendyl chlorhydrate is an azaphenothiazine, an active ingredient of an antipruriginous gel, Apaisyl gel® (Merck Médication Familiale, Dijon, France). "( Contact photoallergy to isothipendyl chlorhydrate.
Bagheri, H; Bibas, N; Bulai Livideanu, C; Chouini-Lalanne, N; Giordano-Labadie, F; Marguery, MC; Maza, A; Nougué, J; Paul, C; Sartor, V, 2012)		2.13

Dosage Studied

ExcerptRelevanceReference
" The recovery of these drugs and their sulphoxides in laboratory-made mixture and dosage forms has been reported."( Determination of isothipendyl or dimethothiazine with their sulphoxides using third- and fourth-derivatives spectroscopy on a diode-array spectrophotometer.
Abdel-Hay, MH; Barary, MH; Elsayed, MA; Hassan, EM, )		0.47
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
tertiary amino compoundA compound formally derived from ammonia by replacing three hydrogen atoms by organyl groups.
aromatic amineAn amino compound in which the amino group is linked directly to an aromatic system.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
Isothipendyl H1-Antihistamine Action87

Research

Studies (24)

TimeframeStudies, This Drug (%)All Drugs %
pre-199018 (75.00)18.7374
1990's1 (4.17)18.2507
2000's2 (8.33)29.6817
2010's2 (8.33)24.3611
2020's1 (4.17)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 37.35

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index37.35 (24.57)
Research Supply Index3.33 (2.92)
Research Growth Index4.64 (4.65)
Search Engine Demand Index55.95 (26.88)
Search Engine Supply Index2.28 (0.95)

This Compound (37.35)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (3.85%)5.53%
Reviews0 (0.00%)6.00%
Case Studies2 (7.69%)4.05%
Observational0 (0.00%)0.25%
Other23 (88.46%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chlorpromazine
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.. chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.		2.2510organochlorine compound;
phenothiazines;
tertiary amine		anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
phenothiazine antipsychotic drug
promethazine
Promethazine: A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.. promethazine : A tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.		2.4420phenothiazines;
tertiary amine		anti-allergic agent;
anticoronaviral agent;
antiemetic;
antipruritic drug;
H1-receptor antagonist;
local anaesthetic;
sedative
edetic acid
Edetic Acid: A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.		1.9810ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid		anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector
pipazethate
pipazethate: RN given refers to parent cpd; structure		710aryl sulfide
molybdenum
Molybdenum: A metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.95. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase.		710chromium group element atommicronutrient
chromium
Chromium: A trace element that plays a role in glucose metabolism. It has the atomic symbol Cr, atomic number 24, and atomic weight 52. According to the Fourth Annual Report on Carcinogens (NTP85-002,1985), chromium and some of its compounds have been listed as known carcinogens.. chromium ion : An chromium atom having a net electric charge.. chromium atom : A chromium group element atom that has atomic number 24.		2.0110chromium group element atom;
metal allergen		micronutrient
chromium
chromium hexavalent ion: a human respiratory carcinogen		2.0110chromium cation;
monoatomic hexacation
chlorproethazine
[no description available]		2.2510phenothiazines
ConditionIndicatedRelationship StrengthStudiesTrials
Dermatitis, Contact, Photoallergic
[description not available]		02.5320
Cardiometabolic Syndrome
A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components not only include metabolic dysfunctions of METABOLIC SYNDROME but also HYPERTENSION, and ABDOMINAL OBESITY.		03.5911
Adolescent Obesity
[description not available]		03.5911
Metabolic Syndrome
A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome include ABDOMINAL OBESITY; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state.		03.5911
Dermatitis, Eczematous
[description not available]		02.0710
Eczema
A pruritic papulovesicular dermatitis occurring as a reaction to many endogenous and exogenous agents (Dorland, 27th ed).		02.0710
Allergic Reaction
[description not available]		02.3420
Diseases of Immune System
[description not available]		01.9310
Hypersensitivity
Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.		14.3420
Immune System Diseases
Disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-mediated, or both.		01.9310
Dermatoses
[description not available]		02.8540
Skin Diseases
Diseases involving the DERMIS or EPIDERMIS.		02.8540
Burns
Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.		02.3420
Injuries, Soft Tissue
[description not available]		01.9310
Hemorrhoids
Swollen veins in the lower part of the RECTUM or ANUS. Hemorrhoids can be inside the anus (internal), under the skin around the anus (external), or protruding from inside to outside of the anus. People with hemorrhoids may or may not exhibit symptoms which include bleeding, itching, and pain.		01.9310
Itching
[description not available]		02.6330
Pruritus
An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.		14.6330
Hematuria
Presence of blood in the urine.		01.9410
Hives
[description not available]		01.9410
Cystitis
Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful urination (dysuria), increased frequency, urgency, and suprapubic pain.		01.9410
Urethritis
Inflammation involving the URETHRA. Similar to CYSTITIS, clinical symptoms range from vague discomfort to painful urination (DYSURIA), urethral discharge, or both.		01.9410
Urticaria
A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.		01.9410
Injuries, Radiation
[description not available]		01.9310
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0110
Contact Dermatitis
[description not available]		01.9610
Hand Dermatosis
[description not available]		01.9610
Dermatitis, Contact
A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.		01.9610
Hand Dermatoses
Skin diseases involving the HANDS.		01.9610
Dermatitis, Contact, Phototoxic
[description not available]		01.9810
Actinic Reticuloid Syndrome
[description not available]		01.9810
Erythema
Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of disease processes.		01.9810