Target type: molecularfunction
Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. [EC:1.2.1.12]
Glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity catalyzes the reversible oxidation of glyceraldehyde-3-phosphate to 1,3-bisphosphoglycerate. This reaction is a key step in glycolysis, the central pathway for energy production in living organisms. The enzyme utilizes NAD+ as a coenzyme, which is reduced to NADH during the oxidation of glyceraldehyde-3-phosphate. The reaction also involves the phosphorylation of glyceraldehyde-3-phosphate by inorganic phosphate, resulting in the formation of 1,3-bisphosphoglycerate. This step is essential for the generation of ATP in glycolysis, as the high-energy phosphate bond in 1,3-bisphosphoglycerate can be transferred to ADP to produce ATP. The active site of glyceraldehyde-3-phosphate dehydrogenase contains a cysteine residue that forms a covalent thiohemiacetal intermediate with glyceraldehyde-3-phosphate during the catalytic process. This intermediate is then oxidized by NAD+, leading to the formation of 1,3-bisphosphoglycerate and the reduction of NAD+ to NADH.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Glyceraldehyde-3-phosphate dehydrogenase | A glyceraldehyde-3-phosphate dehydrogenase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P04406] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| coumarin | 2H-chromen-2-one: coumarin derivative | coumarins | fluorescent dye; human metabolite; plant metabolite |
| oxidopamine | oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease). Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals. | benzenetriol; catecholamine; primary amino compound | drug metabolite; human metabolite; neurotoxin |
| pentamidine | pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease. Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | aromatic ether; carboxamidine; diether | anti-inflammatory agent; antifungal agent; calmodulin antagonist; chemokine receptor 5 antagonist; EC 2.3.1.48 (histone acetyltransferase) inhibitor; NMDA receptor antagonist; S100 calcium-binding protein B inhibitor; trypanocidal drug; xenobiotic |
| osthol | osthol: from Cnidium monnieri and Angelica pubescens (both Apiaceae); structure given in first source | botanical anti-fungal agent; coumarins | metabolite |
| nicotinamide mononucleotide | Nicotinamide Mononucleotide: 3-Carbamoyl-1-beta-D-ribofuranosyl pyridinium hydroxide-5'phosphate, inner salt. A nucleotide in which the nitrogenous base, nicotinamide, is in beta-N-glycosidic linkage with the C-1 position of D-ribose. Synonyms: Nicotinamide Ribonucleotide; NMN. | nicotinamide mononucleotide | Escherichia coli metabolite; mouse metabolite |
| 2-methyladenine | methyladenine : Any member of the class of 6-aminopurines that is adenine bearing a single methyl substituent. | ||
| isopentenyladenosine | Isopentenyladenosine: N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is a member of the cytokinin family of plant growth regulators. N(6)-(Delta(2)-isopentenyl)adenosine : A nucleoside analogue in which adenosine has been modified by substitution at the 6-amino nitrogen by a Delta(2)-isopentenyl group. | N-ribosyl-N(6)-isopentenyladenine; nucleoside analogue | antineoplastic agent; plant growth regulator; plant metabolite |
| benzonidazole | benznidazole : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease. benzonidazole: used in treatment of Chagas' disease | C-nitro compound; imidazoles; monocarboxylic acid amide | antiprotozoal drug |
| adenosine | quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit | adenosines; purines D-ribonucleoside | analgesic; anti-arrhythmia drug; fundamental metabolite; human metabolite; vasodilator agent |
| xanthyletine | xanthyletine: structure | coumarins | |
| metrifudil | |||
| seselin | seselin: structure in first source | coumarins | metabolite |
| n(6)-benzyladenosine | N(6)-benzyladenosine: RN given refers to parent cpd | ||
| 2-methyladenosine | 2-methyladenosine : A methyladenosine in which the methyl group is located at position 2 on the adenine ring. | methyladenosine | |
| n(6)-cyclopentyladenosine | |||
| l 783281 | L 783281: structure in first source | ||
| scopoletin | hydroxycoumarin | plant growth regulator; plant metabolite | |
| 7-hydroxycoumarin | 7-oxycoumarin: derivatives have anti-oxidant properties umbelliferone : A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7. | hydroxycoumarin | fluorescent probe; food component; plant metabolite |