Page last updated: 2024-12-11
grifolin
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
grifolin: antibiotic isolated from Grifola confluens [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 5372312 |
| CHEMBL ID | 487804 |
| CHEBI ID | 170125 |
| SCHEMBL ID | 21065400 |
| MeSH ID | M0163977 |
Synonyms (29)
| Synonym |
|---|
| hexadecyltrimethylammonium pentachlorophenoxide (6ci,7ci) |
| CHEBI:170125 |
| grifolin |
| 1,3-benzenediol, 5-methyl-2-(3,7,11-trimethyl-2,6,10-dodecatrienyl)-, (e,e)- |
| 5-methyl-2-[(2e,6e)-3,7,11-trimethyldodeca-2,6,10-trienyl]benzene-1,3-diol |
| 1,3-benzenediol, 5-methyl-2-[(2e,6e)-3,7,11-trimethyl-2,6,10-dodecatrienyl]- |
| CHEMBL487804 |
| resorcinol, 5-methyl-2-(3,7,11-trimethyl-2,6,10-dodecatrienyl)-, (e,e)- |
| PZHNKNRPGLTZPO-VZRGJMDUSA-N |
| 5-methyl-2-[(2e,6e)-3,7,11-trimethyl-2,6,10-dodecatrienyl]-1,3-benzenediol # |
| 6903-07-7 |
| 5-methyl-2-[(2e,6e)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzene-1,3-diol |
| 2-farnesyl-5-methylresorcinol |
| ammonium, hexadecyltrimethyl-, pentachlorophenoxide (8ci) |
| 5-methyl-2-(3,7,11-trimethyl-2,6,10-dodecatrienyl)-1,3-benzenediol, 9ci |
| e,e,5-methyl-(3,7,11-trimethyl-2,6,10-dodecatrienyl)-1,3-benzenediol |
| Q15634172 |
| SCHEMBL21065400 |
| bdbm50458916 |
| grifolinterpenoid |
| DTXSID401044417 |
| 5-methyl-2-[(2e,6e)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]-1,3-benzenediol |
| AKOS040761803 |
| 5P6UA2GF78 |
| 1,3-benzenediol, 5-methyl-2-((2e,6e)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl)- |
| 5-methyl-2-((2e,6e)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl)-1,3-benzenediol |
| grifolin[terpenoid] |
| HY-N9271 |
| CS-0159145 |
Research Excerpts
Overview
Grifolin is a volatile compound contained in essential oils of several medicinal plants. It is a natural biologically active substance isolated from the fresh fruiting bodies of the mushroom Albatrellus confluens.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Grifolin is a volatile compound contained in essential oils of several medicinal plants. " | ( Pharmacological Effects of Grifolin: Focusing on Anticancer Mechanisms. Bouyahya, A; Catauro, M; El Allam, A; El Omari, N; Goh, BH; Montesano, D; Taha, D; Zengin, G; Zeouk, I, 2022) | 2.46 |
| "Grifolin is a natural biologically active substance isolated from the fresh fruiting bodies of the mushroom Albatrellus confluens. " | ( Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, inhibits tumor cell growth by inducing apoptosis in vitro. Cao, Y; Li, LL; Li, W; Liu, JK; Liu, SF; Lu, ZX; Tan, M; Weng, XX; Ye, M; Zhao, Y, 2005) | 3.21 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Drug Classes (1)
| Class | Description |
|---|---|
| sesquiterpenoid | Any terpenoid derived from a sesquiterpene. The term includes compounds in which the C15 skeleton of the parent sesquiterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups). |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Protein Targets (3)
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 (µMol) | 148.8000 | 0.0005 | 3.8895 | 10.0000 | AID1646857; AID1779361 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 (µMol) | 5.7000 | 0.0005 | 3.4984 | 9.7600 | AID1385463 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 (µMol) | 6.1000 | 0.0006 | 1.6194 | 10.0000 | AID1779362 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Biological Processes (120)
Molecular Functions (28)
Ceullar Components (54)
Bioassays (18)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID332673 | Antitrypanosomal activity against Trypanosoma cruzi Y trypomastigotes assessed as lysis of trypomastigotes at 250 ug/ml after 24 hrs at 4 degC | 1995 | Journal of natural products, Feb, Volume: 58, Issue:2 | Piperogalin, a new prenylated diphenol from Peperomia galioides. |
| AID332682 | Antileishmanial activity against Leishmania braziliensis 2903 promastigotes assessed as immobilized parasites at 10 ug/ml after 24 hrs at 28 degC | 1995 | Journal of natural products, Feb, Volume: 58, Issue:2 | Piperogalin, a new prenylated diphenol from Peperomia galioides. |
| AID1385463 | Inhibition of recombinant human PTP1B catalytic domain (91 to 1053 residues) expressed in Escherichia coli BL21-codon plus (DE3) using pNPP as substrate measured continuously for 3 mins by colorimetric method | 2018 | Journal of natural products, 08-24, Volume: 81, Issue:8 | Enantiomeric Pairs of Meroterpenoids with Diverse Heterocyclic Systems from Rhododendron nyingchiense. |
| AID332684 | Antileishmanial activity against Leishmania amazonensis promastigotes assessed as immobilized parasites at 10 ug/ml after 24 hrs at 28 degC | 1995 | Journal of natural products, Feb, Volume: 58, Issue:2 | Piperogalin, a new prenylated diphenol from Peperomia galioides. |
| AID332680 | Antileishmanial activity against Leishmania donovani PP75 promastigotes assessed as total lysis of parasites at 25 ug/ml after 24 hrs at 28 degC | 1995 | Journal of natural products, Feb, Volume: 58, Issue:2 | Piperogalin, a new prenylated diphenol from Peperomia galioides. |
| AID332679 | Antileishmanial activity against Leishmania braziliensis 2903 promastigotes assessed as total lysis of parasites at 25 ug/ml after 24 hrs at 28 degC | 1995 | Journal of natural products, Feb, Volume: 58, Issue:2 | Piperogalin, a new prenylated diphenol from Peperomia galioides. |
| AID332683 | Antileishmanial activity against Leishmania donovani PP75 promastigotes assessed as immobilized parasites at 10 ug/ml after 24 hrs at 28 degC | 1995 | Journal of natural products, Feb, Volume: 58, Issue:2 | Piperogalin, a new prenylated diphenol from Peperomia galioides. |
| AID402987 | Inhibition of compound 48/80-induced histamine release in Wistar rat peritoneal mast cells | 2004 | Journal of natural products, Jul, Volume: 67, Issue:7 | Structures and histamine release inhibitory effects of prenylated orcinol derivatives from Rhododendron dauricum. |
| AID1779362 | Inhibition of BACE1 (unknown origin) using Rh-EVNNLDAEFK fluorogenic peptide as substrate incubated for 3 hrs by FRET assay | 2021 | Journal of natural products, 06-25, Volume: 84, Issue:6 | Inhibition of BACE1 and Amyloid-β Aggregation by Meroterpenoids from the Mushroom |
| AID332688 | Antileishmanial activity against Leishmania donovani PP75 promastigotes assessed as total lysis of parasites at 100 ug/ml after 24 hrs at 28 degC | 1995 | Journal of natural products, Feb, Volume: 58, Issue:2 | Piperogalin, a new prenylated diphenol from Peperomia galioides. |
| AID1779361 | Inhibition of self-induced aggregation amyloid beta (1 to 40) (unknown origin) incubated for 24 hrs by Thioflavin T based fluorometric assay | 2021 | Journal of natural products, 06-25, Volume: 84, Issue:6 | Inhibition of BACE1 and Amyloid-β Aggregation by Meroterpenoids from the Mushroom |
| AID332677 | Antileishmanial activity against Leishmania donovani PP75 promastigotes assessed as total lysis of parasites at 50 ug/ml after 24 hrs at 28 degC | 1995 | Journal of natural products, Feb, Volume: 58, Issue:2 | Piperogalin, a new prenylated diphenol from Peperomia galioides. |
| AID1646857 | Inhibition of human amyloid beta (1 to 40) aggregation after 24 hrs by ThT fluorescence assay | 2020 | Bioorganic & medicinal chemistry letters, 01-15, Volume: 30, Issue:2 | Isolation of three new meroterpenoids and seven known compounds from Albatrellus yasudae and their Aβ-aggregation inhibitory activity. |
| AID332681 | Antileishmanial activity against Leishmania amazonensis promastigotes assessed as total lysis of parasites at 25 ug/ml after 24 hrs at 28 degC | 1995 | Journal of natural products, Feb, Volume: 58, Issue:2 | Piperogalin, a new prenylated diphenol from Peperomia galioides. |
| AID332689 | Antileishmanial activity against Leishmania amazonensis H142 promastigotes assessed as total lysis of parasites at 100 ug/ml after 24 hrs at 28 degC | 1995 | Journal of natural products, Feb, Volume: 58, Issue:2 | Piperogalin, a new prenylated diphenol from Peperomia galioides. |
| AID332678 | Antileishmanial activity against Leishmania amazonensis promastigotes assessed as total lysis of parasites at 50 ug/ml after 24 hrs at 28 degC | 1995 | Journal of natural products, Feb, Volume: 58, Issue:2 | Piperogalin, a new prenylated diphenol from Peperomia galioides. |
| AID332675 | Antileishmanial activity against Leishmania braziliensis 2903 promastigotes assessed as total lysis of parasites at 100 ug/ml after 24 hrs at 28 degC | 1995 | Journal of natural products, Feb, Volume: 58, Issue:2 | Piperogalin, a new prenylated diphenol from Peperomia galioides. |
| AID332676 | Antileishmanial activity against Leishmania braziliensis 2903 promastigotes assessed as total lysis of parasites at 50 ug/ml after 24 hrs at 28 degC | 1995 | Journal of natural products, Feb, Volume: 58, Issue:2 | Piperogalin, a new prenylated diphenol from Peperomia galioides. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (31)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (6.45) | 18.7374 |
| 1990's | 1 (3.23) | 18.2507 |
| 2000's | 9 (29.03) | 29.6817 |
| 2010's | 12 (38.71) | 24.3611 |
| 2020's | 7 (22.58) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 30.26
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (30.26) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (3.13%) | 5.53% |
| Reviews | 4 (12.50%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 27 (84.38%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||