grifolin profile

grifolin: antibiotic isolated from Grifola confluens [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	5372312
CHEMBL ID	487804
CHEBI ID	170125
SCHEMBL ID	21065400
MeSH ID	M0163977

Synonym
hexadecyltrimethylammonium pentachlorophenoxide (6ci,7ci)
CHEBI:170125
grifolin
1,3-benzenediol, 5-methyl-2-(3,7,11-trimethyl-2,6,10-dodecatrienyl)-, (e,e)-
5-methyl-2-[(2e,6e)-3,7,11-trimethyldodeca-2,6,10-trienyl]benzene-1,3-diol
1,3-benzenediol, 5-methyl-2-[(2e,6e)-3,7,11-trimethyl-2,6,10-dodecatrienyl]-
CHEMBL487804
resorcinol, 5-methyl-2-(3,7,11-trimethyl-2,6,10-dodecatrienyl)-, (e,e)-
PZHNKNRPGLTZPO-VZRGJMDUSA-N
5-methyl-2-[(2e,6e)-3,7,11-trimethyl-2,6,10-dodecatrienyl]-1,3-benzenediol #
6903-07-7
5-methyl-2-[(2e,6e)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzene-1,3-diol
2-farnesyl-5-methylresorcinol
ammonium, hexadecyltrimethyl-, pentachlorophenoxide (8ci)
5-methyl-2-(3,7,11-trimethyl-2,6,10-dodecatrienyl)-1,3-benzenediol, 9ci
e,e,5-methyl-(3,7,11-trimethyl-2,6,10-dodecatrienyl)-1,3-benzenediol
Q15634172
SCHEMBL21065400
bdbm50458916
grifolinterpenoid
DTXSID401044417
5-methyl-2-[(2e,6e)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]-1,3-benzenediol
AKOS040761803
5P6UA2GF78
1,3-benzenediol, 5-methyl-2-((2e,6e)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl)-
5-methyl-2-((2e,6e)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl)-1,3-benzenediol
grifolin[terpenoid]
HY-N9271
CS-0159145

Excerpt	Reference	Relevance
"Grifolin is a volatile compound contained in essential oils of several medicinal plants. "	( Pharmacological Effects of Grifolin: Focusing on Anticancer Mechanisms. Bouyahya, A; Catauro, M; El Allam, A; El Omari, N; Goh, BH; Montesano, D; Taha, D; Zengin, G; Zeouk, I, 2022)	2.46
"Grifolin is a natural biologically active substance isolated from the fresh fruiting bodies of the mushroom Albatrellus confluens. "	( Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, inhibits tumor cell growth by inducing apoptosis in vitro. Cao, Y; Li, LL; Li, W; Liu, JK; Liu, SF; Lu, ZX; Tan, M; Weng, XX; Ye, M; Zhao, Y, 2005)	3.21

Class	Description
sesquiterpenoid	Any terpenoid derived from a sesquiterpene. The term includes compounds in which the C15 skeleton of the parent sesquiterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (3)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Amyloid-beta precursor protein	Homo sapiens (human)	IC50 (µMol)	148.8000	0.0005	3.8895	10.0000	AID1646857; AID1779361
Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)	IC50 (µMol)	5.7000	0.0005	3.4984	9.7600	AID1385463
Beta-secretase 1	Homo sapiens (human)	IC50 (µMol)	6.1000	0.0006	1.6194	10.0000	AID1779362
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (120)

Process	via Protein(s)	Taxonomy
regulation of gene expression	Amyloid-beta precursor protein	Homo sapiens (human)
cognition	Amyloid-beta precursor protein	Homo sapiens (human)
G2/M transition of mitotic cell cycle	Amyloid-beta precursor protein	Homo sapiens (human)
microglial cell activation	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of protein phosphorylation	Amyloid-beta precursor protein	Homo sapiens (human)
suckling behavior	Amyloid-beta precursor protein	Homo sapiens (human)
astrocyte activation involved in immune response	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of translation	Amyloid-beta precursor protein	Homo sapiens (human)
protein phosphorylation	Amyloid-beta precursor protein	Homo sapiens (human)
intracellular copper ion homeostasis	Amyloid-beta precursor protein	Homo sapiens (human)
endocytosis	Amyloid-beta precursor protein	Homo sapiens (human)
response to oxidative stress	Amyloid-beta precursor protein	Homo sapiens (human)
cell adhesion	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of epidermal growth factor-activated receptor activity	Amyloid-beta precursor protein	Homo sapiens (human)
Notch signaling pathway	Amyloid-beta precursor protein	Homo sapiens (human)
axonogenesis	Amyloid-beta precursor protein	Homo sapiens (human)
learning or memory	Amyloid-beta precursor protein	Homo sapiens (human)
learning	Amyloid-beta precursor protein	Homo sapiens (human)
mating behavior	Amyloid-beta precursor protein	Homo sapiens (human)
locomotory behavior	Amyloid-beta precursor protein	Homo sapiens (human)
axo-dendritic transport	Amyloid-beta precursor protein	Homo sapiens (human)
cholesterol metabolic process	Amyloid-beta precursor protein	Homo sapiens (human)
negative regulation of cell population proliferation	Amyloid-beta precursor protein	Homo sapiens (human)
adult locomotory behavior	Amyloid-beta precursor protein	Homo sapiens (human)
visual learning	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of gene expression	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of gene expression	Amyloid-beta precursor protein	Homo sapiens (human)
negative regulation of gene expression	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of peptidyl-threonine phosphorylation	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of G2/M transition of mitotic cell cycle	Amyloid-beta precursor protein	Homo sapiens (human)
microglia development	Amyloid-beta precursor protein	Homo sapiens (human)
axon midline choice point recognition	Amyloid-beta precursor protein	Homo sapiens (human)
neuron remodeling	Amyloid-beta precursor protein	Homo sapiens (human)
dendrite development	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of Wnt signaling pathway	Amyloid-beta precursor protein	Homo sapiens (human)
extracellular matrix organization	Amyloid-beta precursor protein	Homo sapiens (human)
forebrain development	Amyloid-beta precursor protein	Homo sapiens (human)
neuron projection development	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of chemokine production	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of interleukin-1 beta production	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of interleukin-6 production	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of tumor necrosis factor production	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	Amyloid-beta precursor protein	Homo sapiens (human)
ionotropic glutamate receptor signaling pathway	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of multicellular organism growth	Amyloid-beta precursor protein	Homo sapiens (human)
negative regulation of neuron differentiation	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of glycolytic process	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of mitotic cell cycle	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of JNK cascade	Amyloid-beta precursor protein	Homo sapiens (human)
astrocyte activation	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of long-term neuronal synaptic plasticity	Amyloid-beta precursor protein	Homo sapiens (human)
collateral sprouting in absence of injury	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of inflammatory response	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of peptidyl-tyrosine phosphorylation	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of synapse structure or activity	Amyloid-beta precursor protein	Homo sapiens (human)
synapse organization	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of calcium-mediated signaling	Amyloid-beta precursor protein	Homo sapiens (human)
neuromuscular process controlling balance	Amyloid-beta precursor protein	Homo sapiens (human)
synaptic assembly at neuromuscular junction	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of protein metabolic process	Amyloid-beta precursor protein	Homo sapiens (human)
neuron apoptotic process	Amyloid-beta precursor protein	Homo sapiens (human)
smooth endoplasmic reticulum calcium ion homeostasis	Amyloid-beta precursor protein	Homo sapiens (human)
neuron cellular homeostasis	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Amyloid-beta precursor protein	Homo sapiens (human)
response to interleukin-1	Amyloid-beta precursor protein	Homo sapiens (human)
modulation of excitatory postsynaptic potential	Amyloid-beta precursor protein	Homo sapiens (human)
NMDA selective glutamate receptor signaling pathway	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of spontaneous synaptic transmission	Amyloid-beta precursor protein	Homo sapiens (human)
cytosolic mRNA polyadenylation	Amyloid-beta precursor protein	Homo sapiens (human)
negative regulation of long-term synaptic potentiation	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of long-term synaptic potentiation	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of non-canonical NF-kappaB signal transduction	Amyloid-beta precursor protein	Homo sapiens (human)
cellular response to amyloid-beta	Amyloid-beta precursor protein	Homo sapiens (human)
regulation of presynapse assembly	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of amyloid fibril formation	Amyloid-beta precursor protein	Homo sapiens (human)
amyloid fibril formation	Amyloid-beta precursor protein	Homo sapiens (human)
neuron projection maintenance	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of T cell migration	Amyloid-beta precursor protein	Homo sapiens (human)
central nervous system development	Amyloid-beta precursor protein	Homo sapiens (human)
positive regulation of JUN kinase activity	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
protein dephosphorylation	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
insulin receptor signaling pathway	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
regulation of signal transduction	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
negative regulation of signal transduction	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
actin cytoskeleton organization	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
regulation of endocytosis	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
negative regulation of vascular endothelial growth factor receptor signaling pathway	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
endoplasmic reticulum unfolded protein response	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
regulation of intracellular protein transport	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
cellular response to unfolded protein	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
peptidyl-tyrosine dephosphorylation	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
platelet-derived growth factor receptor-beta signaling pathway	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
IRE1-mediated unfolded protein response	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
insulin receptor recycling	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
negative regulation of MAP kinase activity	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
negative regulation of insulin receptor signaling pathway	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
regulation of type I interferon-mediated signaling pathway	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
growth hormone receptor signaling pathway via JAK-STAT	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
positive regulation of protein tyrosine kinase activity	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascade	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
regulation of hepatocyte growth factor receptor signaling pathway	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
positive regulation of IRE1-mediated unfolded protein response	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
negative regulation of PERK-mediated unfolded protein response	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
positive regulation of receptor catabolic process	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
proteolysis	Beta-secretase 1	Homo sapiens (human)
membrane protein ectodomain proteolysis	Beta-secretase 1	Homo sapiens (human)
response to lead ion	Beta-secretase 1	Homo sapiens (human)
protein processing	Beta-secretase 1	Homo sapiens (human)
amyloid-beta formation	Beta-secretase 1	Homo sapiens (human)
amyloid precursor protein catabolic process	Beta-secretase 1	Homo sapiens (human)
positive regulation of neuron apoptotic process	Beta-secretase 1	Homo sapiens (human)
amyloid-beta metabolic process	Beta-secretase 1	Homo sapiens (human)
detection of mechanical stimulus involved in sensory perception of pain	Beta-secretase 1	Homo sapiens (human)
prepulse inhibition	Beta-secretase 1	Homo sapiens (human)
cellular response to copper ion	Beta-secretase 1	Homo sapiens (human)
cellular response to manganese ion	Beta-secretase 1	Homo sapiens (human)
presynaptic modulation of chemical synaptic transmission	Beta-secretase 1	Homo sapiens (human)
signaling receptor ligand precursor processing	Beta-secretase 1	Homo sapiens (human)
cellular response to amyloid-beta	Beta-secretase 1	Homo sapiens (human)
amyloid fibril formation	Beta-secretase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (28)

Process	via Protein(s)	Taxonomy
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Amyloid-beta precursor protein	Homo sapiens (human)
DNA binding	Amyloid-beta precursor protein	Homo sapiens (human)
serine-type endopeptidase inhibitor activity	Amyloid-beta precursor protein	Homo sapiens (human)
signaling receptor binding	Amyloid-beta precursor protein	Homo sapiens (human)
protein binding	Amyloid-beta precursor protein	Homo sapiens (human)
heparin binding	Amyloid-beta precursor protein	Homo sapiens (human)
enzyme binding	Amyloid-beta precursor protein	Homo sapiens (human)
identical protein binding	Amyloid-beta precursor protein	Homo sapiens (human)
transition metal ion binding	Amyloid-beta precursor protein	Homo sapiens (human)
receptor ligand activity	Amyloid-beta precursor protein	Homo sapiens (human)
PTB domain binding	Amyloid-beta precursor protein	Homo sapiens (human)
protein serine/threonine kinase binding	Amyloid-beta precursor protein	Homo sapiens (human)
signaling receptor activator activity	Amyloid-beta precursor protein	Homo sapiens (human)
RNA binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
protein tyrosine phosphatase activity	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
insulin receptor binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
protein binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
zinc ion binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
enzyme binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
protein kinase binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
receptor tyrosine kinase binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
cadherin binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
ephrin receptor binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
protein phosphatase 2A binding	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
non-membrane spanning protein tyrosine phosphatase activity	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
amyloid-beta binding	Beta-secretase 1	Homo sapiens (human)
endopeptidase activity	Beta-secretase 1	Homo sapiens (human)
aspartic-type endopeptidase activity	Beta-secretase 1	Homo sapiens (human)
protein binding	Beta-secretase 1	Homo sapiens (human)
peptidase activity	Beta-secretase 1	Homo sapiens (human)
beta-aspartyl-peptidase activity	Beta-secretase 1	Homo sapiens (human)
enzyme binding	Beta-secretase 1	Homo sapiens (human)
protein serine/threonine kinase binding	Beta-secretase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (54)

Process	via Protein(s)	Taxonomy
extracellular space	Amyloid-beta precursor protein	Homo sapiens (human)
dendrite	Amyloid-beta precursor protein	Homo sapiens (human)
extracellular region	Amyloid-beta precursor protein	Homo sapiens (human)
extracellular space	Amyloid-beta precursor protein	Homo sapiens (human)
nuclear envelope lumen	Amyloid-beta precursor protein	Homo sapiens (human)
cytoplasm	Amyloid-beta precursor protein	Homo sapiens (human)
mitochondrial inner membrane	Amyloid-beta precursor protein	Homo sapiens (human)
endosome	Amyloid-beta precursor protein	Homo sapiens (human)
early endosome	Amyloid-beta precursor protein	Homo sapiens (human)
endoplasmic reticulum	Amyloid-beta precursor protein	Homo sapiens (human)
endoplasmic reticulum lumen	Amyloid-beta precursor protein	Homo sapiens (human)
smooth endoplasmic reticulum	Amyloid-beta precursor protein	Homo sapiens (human)
Golgi apparatus	Amyloid-beta precursor protein	Homo sapiens (human)
Golgi lumen	Amyloid-beta precursor protein	Homo sapiens (human)
Golgi-associated vesicle	Amyloid-beta precursor protein	Homo sapiens (human)
cytosol	Amyloid-beta precursor protein	Homo sapiens (human)
plasma membrane	Amyloid-beta precursor protein	Homo sapiens (human)
clathrin-coated pit	Amyloid-beta precursor protein	Homo sapiens (human)
cell-cell junction	Amyloid-beta precursor protein	Homo sapiens (human)
synaptic vesicle	Amyloid-beta precursor protein	Homo sapiens (human)
cell surface	Amyloid-beta precursor protein	Homo sapiens (human)
membrane	Amyloid-beta precursor protein	Homo sapiens (human)
COPII-coated ER to Golgi transport vesicle	Amyloid-beta precursor protein	Homo sapiens (human)
axon	Amyloid-beta precursor protein	Homo sapiens (human)
growth cone	Amyloid-beta precursor protein	Homo sapiens (human)
platelet alpha granule lumen	Amyloid-beta precursor protein	Homo sapiens (human)
neuromuscular junction	Amyloid-beta precursor protein	Homo sapiens (human)
endosome lumen	Amyloid-beta precursor protein	Homo sapiens (human)
trans-Golgi network membrane	Amyloid-beta precursor protein	Homo sapiens (human)
ciliary rootlet	Amyloid-beta precursor protein	Homo sapiens (human)
dendritic spine	Amyloid-beta precursor protein	Homo sapiens (human)
dendritic shaft	Amyloid-beta precursor protein	Homo sapiens (human)
perikaryon	Amyloid-beta precursor protein	Homo sapiens (human)
membrane raft	Amyloid-beta precursor protein	Homo sapiens (human)
apical part of cell	Amyloid-beta precursor protein	Homo sapiens (human)
synapse	Amyloid-beta precursor protein	Homo sapiens (human)
perinuclear region of cytoplasm	Amyloid-beta precursor protein	Homo sapiens (human)
presynaptic active zone	Amyloid-beta precursor protein	Homo sapiens (human)
spindle midzone	Amyloid-beta precursor protein	Homo sapiens (human)
recycling endosome	Amyloid-beta precursor protein	Homo sapiens (human)
extracellular exosome	Amyloid-beta precursor protein	Homo sapiens (human)
receptor complex	Amyloid-beta precursor protein	Homo sapiens (human)
early endosome	Amyloid-beta precursor protein	Homo sapiens (human)
membrane raft	Amyloid-beta precursor protein	Homo sapiens (human)
cell surface	Amyloid-beta precursor protein	Homo sapiens (human)
Golgi apparatus	Amyloid-beta precursor protein	Homo sapiens (human)
plasma membrane	Amyloid-beta precursor protein	Homo sapiens (human)
plasma membrane	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
cytoplasm	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
mitochondrial matrix	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
early endosome	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
endoplasmic reticulum	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
cytosol	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
mitochondrial crista	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
endosome lumen	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
sorting endosome	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
cytoplasmic side of endoplasmic reticulum membrane	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
protein-containing complex	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
endoplasmic reticulum	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
cytoplasm	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
early endosome	Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)
lysosome	Beta-secretase 1	Homo sapiens (human)
endosome	Beta-secretase 1	Homo sapiens (human)
early endosome	Beta-secretase 1	Homo sapiens (human)
late endosome	Beta-secretase 1	Homo sapiens (human)
multivesicular body	Beta-secretase 1	Homo sapiens (human)
endoplasmic reticulum lumen	Beta-secretase 1	Homo sapiens (human)
Golgi apparatus	Beta-secretase 1	Homo sapiens (human)
trans-Golgi network	Beta-secretase 1	Homo sapiens (human)
plasma membrane	Beta-secretase 1	Homo sapiens (human)
synaptic vesicle	Beta-secretase 1	Homo sapiens (human)
cell surface	Beta-secretase 1	Homo sapiens (human)
endosome membrane	Beta-secretase 1	Homo sapiens (human)
membrane	Beta-secretase 1	Homo sapiens (human)
axon	Beta-secretase 1	Homo sapiens (human)
dendrite	Beta-secretase 1	Homo sapiens (human)
neuronal cell body	Beta-secretase 1	Homo sapiens (human)
membrane raft	Beta-secretase 1	Homo sapiens (human)
recycling endosome	Beta-secretase 1	Homo sapiens (human)
Golgi-associated vesicle lumen	Beta-secretase 1	Homo sapiens (human)
hippocampal mossy fiber to CA3 synapse	Beta-secretase 1	Homo sapiens (human)
endosome	Beta-secretase 1	Homo sapiens (human)
plasma membrane	Beta-secretase 1	Homo sapiens (human)
trans-Golgi network	Beta-secretase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (18)

Assay ID	Title	Year	Journal	Article
AID332673	Antitrypanosomal activity against Trypanosoma cruzi Y trypomastigotes assessed as lysis of trypomastigotes at 250 ug/ml after 24 hrs at 4 degC	1995	Journal of natural products, Feb, Volume: 58, Issue:2	Piperogalin, a new prenylated diphenol from Peperomia galioides.
AID332682	Antileishmanial activity against Leishmania braziliensis 2903 promastigotes assessed as immobilized parasites at 10 ug/ml after 24 hrs at 28 degC	1995	Journal of natural products, Feb, Volume: 58, Issue:2	Piperogalin, a new prenylated diphenol from Peperomia galioides.
AID1385463	Inhibition of recombinant human PTP1B catalytic domain (91 to 1053 residues) expressed in Escherichia coli BL21-codon plus (DE3) using pNPP as substrate measured continuously for 3 mins by colorimetric method	2018	Journal of natural products, 08-24, Volume: 81, Issue:8	Enantiomeric Pairs of Meroterpenoids with Diverse Heterocyclic Systems from Rhododendron nyingchiense.
AID332684	Antileishmanial activity against Leishmania amazonensis promastigotes assessed as immobilized parasites at 10 ug/ml after 24 hrs at 28 degC	1995	Journal of natural products, Feb, Volume: 58, Issue:2	Piperogalin, a new prenylated diphenol from Peperomia galioides.
AID332680	Antileishmanial activity against Leishmania donovani PP75 promastigotes assessed as total lysis of parasites at 25 ug/ml after 24 hrs at 28 degC	1995	Journal of natural products, Feb, Volume: 58, Issue:2	Piperogalin, a new prenylated diphenol from Peperomia galioides.
AID332679	Antileishmanial activity against Leishmania braziliensis 2903 promastigotes assessed as total lysis of parasites at 25 ug/ml after 24 hrs at 28 degC	1995	Journal of natural products, Feb, Volume: 58, Issue:2	Piperogalin, a new prenylated diphenol from Peperomia galioides.
AID332683	Antileishmanial activity against Leishmania donovani PP75 promastigotes assessed as immobilized parasites at 10 ug/ml after 24 hrs at 28 degC	1995	Journal of natural products, Feb, Volume: 58, Issue:2	Piperogalin, a new prenylated diphenol from Peperomia galioides.
AID402987	Inhibition of compound 48/80-induced histamine release in Wistar rat peritoneal mast cells	2004	Journal of natural products, Jul, Volume: 67, Issue:7	Structures and histamine release inhibitory effects of prenylated orcinol derivatives from Rhododendron dauricum.
AID1779362	Inhibition of BACE1 (unknown origin) using Rh-EVNNLDAEFK fluorogenic peptide as substrate incubated for 3 hrs by FRET assay	2021	Journal of natural products, 06-25, Volume: 84, Issue:6	Inhibition of BACE1 and Amyloid-β Aggregation by Meroterpenoids from the Mushroom
AID332688	Antileishmanial activity against Leishmania donovani PP75 promastigotes assessed as total lysis of parasites at 100 ug/ml after 24 hrs at 28 degC	1995	Journal of natural products, Feb, Volume: 58, Issue:2	Piperogalin, a new prenylated diphenol from Peperomia galioides.
AID1779361	Inhibition of self-induced aggregation amyloid beta (1 to 40) (unknown origin) incubated for 24 hrs by Thioflavin T based fluorometric assay	2021	Journal of natural products, 06-25, Volume: 84, Issue:6	Inhibition of BACE1 and Amyloid-β Aggregation by Meroterpenoids from the Mushroom
AID332677	Antileishmanial activity against Leishmania donovani PP75 promastigotes assessed as total lysis of parasites at 50 ug/ml after 24 hrs at 28 degC	1995	Journal of natural products, Feb, Volume: 58, Issue:2	Piperogalin, a new prenylated diphenol from Peperomia galioides.
AID1646857	Inhibition of human amyloid beta (1 to 40) aggregation after 24 hrs by ThT fluorescence assay	2020	Bioorganic & medicinal chemistry letters, 01-15, Volume: 30, Issue:2	Isolation of three new meroterpenoids and seven known compounds from Albatrellus yasudae and their Aβ-aggregation inhibitory activity.
AID332681	Antileishmanial activity against Leishmania amazonensis promastigotes assessed as total lysis of parasites at 25 ug/ml after 24 hrs at 28 degC	1995	Journal of natural products, Feb, Volume: 58, Issue:2	Piperogalin, a new prenylated diphenol from Peperomia galioides.
AID332689	Antileishmanial activity against Leishmania amazonensis H142 promastigotes assessed as total lysis of parasites at 100 ug/ml after 24 hrs at 28 degC	1995	Journal of natural products, Feb, Volume: 58, Issue:2	Piperogalin, a new prenylated diphenol from Peperomia galioides.
AID332678	Antileishmanial activity against Leishmania amazonensis promastigotes assessed as total lysis of parasites at 50 ug/ml after 24 hrs at 28 degC	1995	Journal of natural products, Feb, Volume: 58, Issue:2	Piperogalin, a new prenylated diphenol from Peperomia galioides.
AID332675	Antileishmanial activity against Leishmania braziliensis 2903 promastigotes assessed as total lysis of parasites at 100 ug/ml after 24 hrs at 28 degC	1995	Journal of natural products, Feb, Volume: 58, Issue:2	Piperogalin, a new prenylated diphenol from Peperomia galioides.
AID332676	Antileishmanial activity against Leishmania braziliensis 2903 promastigotes assessed as total lysis of parasites at 50 ug/ml after 24 hrs at 28 degC	1995	Journal of natural products, Feb, Volume: 58, Issue:2	Piperogalin, a new prenylated diphenol from Peperomia galioides.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (6.45)	18.7374
1990's	1 (3.23)	18.2507
2000's	9 (29.03)	29.6817
2010's	12 (38.71)	24.3611
2020's	7 (22.58)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (3.13%)	5.53%
Reviews	4 (12.50%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	27 (84.38%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
indomethacin Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.	2.02	1	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic
catechin Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.. catechin : Members of the class of hydroxyflavan that have a flavan-3-ol skeleton and its substituted derivatives.. rac-catechin : A racemate comprising equimolar amounts of (+)- and (-)-catechin. (+)-catechin : The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.	3.21	1	catechin	antioxidant; plant metabolite
orcinol orcinol: used as reagent for pentoses, lignin, beet sugar, saccharoses, arabinose & diastase; RN given refers to parent cpd; structure. orcinol : A 5-alkylresorcinol in which the alkyl group is specified as methyl.	2.02	1	5-alkylresorcinol; dihydroxytoluene	Aspergillus metabolite
oleanolic acid [no description available]	2.17	1	hydroxy monocarboxylic acid; pentacyclic triterpenoid	plant metabolite
epigallocatechin gallate epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis). (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.	3.21	1	flavans; gallate ester; polyphenol	antineoplastic agent; antioxidant; apoptosis inducer; geroprotector; Hsp90 inhibitor; neuroprotective agent; plant metabolite
medica 16 MEDICA 16 : An alpha,omega-dicarboxylic acid that is hexadecanedioic acid carrying methyl groups at positions 3 and 14. It is a free fatty acid 1 (FFA1/GPR40) receptor agonist and an ATP citrate lyase inhibitor, and exhibits hypolipidemic and antidiabetogenic properties.	2.05	1	alpha,omega-dicarboxylic acid	antilipemic drug; EC 2.3.3.8 (ATP citrate synthase) inhibitor; EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor; G-protein-coupled receptor agonist; hypoglycemic agent
sesquiterpenes [no description available]	3.21	1
myricetin [no description available]	2.69	2	7-hydroxyflavonol; hexahydroxyflavone	antineoplastic agent; antioxidant; cyclooxygenase 1 inhibitor; food component; geroprotector; hypoglycemic agent; plant metabolite
cannabigerol cannabigerol: RN given refers to (E)-isomer; structure given in first source. cannabigerol : A member of the class of resorcinols that is resorcinol which is substituted by a (2E)-3,7-dimethylocta-2,6-dien-1-yl group at position 2 and by a pentyl group at position 5. It is a natural product found in Cannabis sativa and Helichrysum species.	7.25	1	phytocannabinoid; resorcinols	anti-inflammatory agent; antibacterial agent; antioxidant; appetite enhancer; cannabinoid receptor agonist; neuroprotective agent; plant metabolite
licochalcone a licochalcone A: has both anti-inflammatory and antineoplastic activities; structure given in first source; isolated from root of Glycyrrhiza inflata; RN given refers to (E)-isomer	2.6	1	chalcones
daurichromenic acid daurichromenic acid: structure in first source	2.25	1
aluminum oxide Aluminum Oxide: An oxide of aluminum, occurring in nature as various minerals such as bauxite, corundum, etc. It is used as an adsorbent, desiccating agent, and catalyst, and in the manufacture of dental cements and refractories.	2.25	1
cytochrome c-t Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.	2.43	2
sodium hypochlorite Sodium Hypochlorite: It is used as an oxidizing and bleaching agent and as a disinfectant. (From Grant & Hackh's Chemical Dictionary, 5th ed). sodium hypochlorite : An inorganic sodium salt in which hypochlorite is the counterion. It is used as a bleaching and disinfecting agent and is commonly found in household bleach.	2	1	inorganic sodium salt	bleaching agent; disinfectant
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone: an interleukin-1beta converting enzyme (ICE)-like protease inhibitor	2.03	1

Condition	Relationship Strength	Studies
Acute Confusional Senile Dementia [description not available]	2.69	2
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	2.69	2
Benign Neoplasms [description not available]	3.71	3
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	3.71	3
Cancer of Colon [description not available]	2.52	2
Colonic Neoplasms Tumors or cancer of the COLON.	2.52	2
Cancer of Nasopharynx [description not available]	3.71	3
Nasopharyngeal Neoplasms Tumors or cancer of the NASOPHARYNX.	3.71	3
Nasopharyngeal Carcinoma A carcinoma that originates in the EPITHELIUM of the NASOPHARYNX and includes four subtypes: keratinizing squamous cell, non-keratinizing, basaloid squamous cell, and PAPILLARY ADENOCARCINOMA. It is most prevalent in Southeast Asian populations and is associated with EPSTEIN-BARR VIRUS INFECTIONS. Somatic mutations associated with this cancer have been identified in NPCR, BAP1, UBAP1, ERBB2, ERBB3, MLL2, PIK3CA, KRAS, NRAS, and ARID1A genes.	2.51	2
Metastase [description not available]	2.11	1
Invasiveness, Neoplasm [description not available]	2.53	2
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	2.11	1
Cancer of Ovary [description not available]	2.13	1
Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.	2.13	1
Cancer of Stomach [description not available]	2.15	1
Stomach Neoplasms Tumors or cancer of the STOMACH.	2.15	1
Breast Cancer [description not available]	2.06	1
Carcinoma, Anaplastic [description not available]	2.06	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.06	1
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	7.06	1
Osteogenic Sarcoma [description not available]	2.03	1
Osteosarcoma A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)	7.03	1
Sarcoma 180 An experimental sarcoma of mice.	2	1
Angiitis [description not available]	2	1
Vasculitis Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.	2	1

grifolin

Description

Cross-References

Synonyms (29)

Research Excerpts

Overview

Drug Classes (1)

Protein Targets (3)

Inhibition Measurements

Biological Processes (120)

Molecular Functions (28)

Ceullar Components (54)

Bioassays (18)

Research

Studies (31)

Market Indicators

Research Demand Index: 30.26

Study Types

grifolin

Description

Cross-References

Synonyms (29)

Research Excerpts

Overview

Drug Classes (1)

Protein Targets (3)

Inhibition Measurements

Biological Processes (120)

Molecular Functions (28)

Ceullar Components (54)

Bioassays (18)

Research

Studies (31)

Market Indicators

Research Demand Index: 30.26

Study Types

Related Drugs (15)

Related Conditions (25)