ethonium profile

Ethonium: Russian drug; RN given refers to dichloride [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	30869
MeSH ID	M0046138

Synonym
ethonium
1,2-ethanediaminium, n,n'-bis(2-(decyloxy)-2-oxoethyl)-n,n,n',n'-tetramethyl-, dichloride
n,n'-bis(decyloxycarbonylmethyl)-n,n,n',n'-tetramethylethylenediammonium chloride
ethylenebis((carboxymethyl)dimethylammonium), dichloride, didecyl ester
etonium
n,n'-bis(2-(decyloxy)-2-oxoethyl)-n,n,n',n'-tetramethyl-1,2-ethanediaminium
1,2-ethylenediamine, n,n'-dicarboxymethyl-n,n'-dimethyl-, dimethochloride, didecyl ester
n,n-bis(carboxymethyl)-n,n,n',n'-tetramethylethylenediammonium chloride
ammonium, ethylenebis((carboxymethyl)dimethyl-, dichloride, didecyl ester
21954-74-5
AKOS024399265
n~1~,n~2~-bis[2-(decyloxy)-2-oxoethyl]-n~1~,n~1~,n~2~,n~2~-tetramethylethane-1,2-bis(aminium) dichloride
108316-83-2
DTXSID50910680
(2-decoxy-2-oxoethyl)-[2-[(2-decoxy-2-oxoethyl)-dimethylazaniumyl]ethyl]-dimethylazanium;dichloride

Excerpt	Reference	Relevance
"Ethonium is an antimicrobial drug of the group of cationic surface-active substances."	( [Joint action of ethonium and antibiotics on gram-positive and gram-negative microorganisms]. Gudz', OV; Pis'ko, GT, 1982)	1.33

Excerpt	Reference	Relevance
"Ethonium induces an increase in the percentage of irreplaceable polyene acids in total lipids, activity of lipase and CME in tissues as well as average diurnal increments and preservation percent of youngs."	( [The effect of ethonium on the fatty acid composition of the lipids in the hepatic and muscular tissues of hypotrophic piglets]. Pavliuk, IM, )	1.21

Excerpt	Reference	Relevance
" aeruginosa increased approximately 20 times when it was used in combination with ethonium, a derivative of bis-quaternary ammonium compounds."	( [Gentamycin activity in combination with etonium in relation to Pseudomonas aeruginosa]. Rozhavin, MA; Sologub, VV; Tydel'skaia, IL, 1979)	0.49

Excerpt	Relevance	Reference
"Ligenten gel is a combined dosage form containing gentamicin (a broad spectrum antibiotic), lidocaine (an anesthetic) and ethonium (an antiseptic)."	( [Ligenten--a combination drug with anesthetic and antibacterial action for local use in urology and gynecology]. Darenkov, AF; Kotliarova, GA; Lebed', SV; Makarov, OV; Perepanova, TS; Savchenko, TN; Strachunskiĭ, LS; Tsibina, LV; Vasil'ev, MM; Zharov, EV, 1994)	0.5

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	21 (56.76)	18.7374
1990's	12 (32.43)	18.2507
2000's	3 (8.11)	29.6817
2010's	1 (2.70)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	3 (5.00%)	5.53%
Reviews	2 (3.33%)	6.00%
Case Studies	1 (1.67%)	4.05%
Observational	0 (0.00%)	0.25%
Other	54 (90.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
dimethyl sulfoxide Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.	1.96	1	0	sulfoxide; volatile organic compound	alkylating agent; antidote; Escherichia coli metabolite; geroprotector; MRI contrast agent; non-narcotic analgesic; polar aprotic solvent; radical scavenger
formaldehyde paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy	1.98	1	0	aldehyde; one-carbon compound	allergen; carcinogenic agent; disinfectant; EC 3.5.1.4 (amidase) inhibitor; environmental contaminant; Escherichia coli metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
aspirin Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5). acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.. acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.	2.1	1	0	benzoic acids; phenyl acetates; salicylates	anticoagulant; antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; EC 1.1.1.188 (prostaglandin-F synthase) inhibitor; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug; plant activator; platelet aggregation inhibitor; prostaglandin antagonist; teratogenic agent
diminazene Diminazene: An effective trypanocidal agent.. diminazene : A triazene derivative that is triazene in which each of the terminal nitrogens is substituted by a 4-carbamimidoylphenyl group.	1.96	1	0	carboxamidine; triazene derivative	antiparasitic agent; trypanocidal drug
decamethonium decamethonium: RN given refers to parent cpd. decamethonium : A quaternary ammonium ion that is a depolarising muscle relaxant whose structure comprises a decane-1,10-diamine core in which each amino group carries three methyl substituents.	2.01	1	0	quaternary ammonium ion	muscle relaxant; nicotinic acetylcholine receptor agonist
diclofenac Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.. diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.	1.98	1	0	amino acid; aromatic amine; dichlorobenzene; monocarboxylic acid; secondary amino compound	antipyretic; drug allergen; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic
gentamicin Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.	3.76	2	1
lidocaine Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.. lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.	3.37	1	1	benzenes; monocarboxylic acid amide; tertiary amino compound	anti-arrhythmia drug; drug allergen; environmental contaminant; local anaesthetic; xenobiotic
tubocurarine Tubocurarine: A neuromuscular blocker and active ingredient in CURARE; plant based alkaloid of Menispermaceae.. tubocurarine : A benzylisoquinoline alkaloid muscle relaxant which constitutes the active component of curare.. isoquinoline alkaloid : Any alkaloid that has a structure based on an isoquinoline nucleus. They are derived from the amino acids like tyrosine and phenylalanine.	1.94	1	0	bisbenzylisoquinoline alkaloid	drug allergen; muscle relaxant; nicotinic antagonist
1,2-dipalmitoylphosphatidylcholine 1,2-Dipalmitoylphosphatidylcholine: Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	2.44	2	0
n-vinyl-2-pyrrolidinone N-vinyl-2-pyrrolidinone: monomer of POVIDONE; structure given in first source	1.96	1	0	pyrrolidin-2-ones
nandrolone decanoate Nandrolone Decanoate: Decanoic acid ester of nandrolone that is used as an anabolic agent to prevent or treat WASTING SYNDROME associated with severe chronic illness or HIV infection (HIV WASTING SYNDROME). It may also be used in the treatment of POSTMENOPAUSAL OSTEOPOROSIS.	1.97	1	0	steroid ester
nandrolone Nandrolone: C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less one carbon at the 19 position.. nandrolone : A 3-oxo Delta(4)-steroid that is estr-4-en-3-one substituted by a beta-hydroxy group at position 17.	1.97	1	0	17beta-hydroxy steroid; 3-oxo-Delta(4) steroid; anabolic androgenic steroid	human metabolite
dodeconium dodeconium: RN given refers to dichloride; see also record for ethonium	2.36	2	0
tris(2,3-dibromopropyl)phosphate tris(2,3-dibromopropyl)phosphate: flame retardant	1.93	1	0	trialkyl phosphate
isometamidium chloride isometamidium chloride: Samorin & Veridium are tradenames	1.96	1	0	organic molecular entity
thionium [no description available]	2.1	1	0
deoxycholic acid Deoxycholic Acid: A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.. deoxycholic acid : A bile acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively.	1.96	1	0	bile acid; C24-steroid; dihydroxy-5beta-cholanic acid	human blood serum metabolite
sodium dodecyl sulfate Sodium Dodecyl Sulfate: An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.. sodium dodecyl sulfate : An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.	1.96	1	0	organic sodium salt	detergent; protein denaturant
diminazene aceturate diminazene diaceturate : An N-acetylglycinate salt resulting from the reaction of diminazene with 2 mol eq. of N-acetylglycine.	1.96	1	0	N-acetylglycinate salt	antiparasitic agent; trypanocidal drug
piperidines Piperidines: A family of hexahydropyridines.	1.95	1	0

Condition	Relationship Strength	Studies	Trials
Pulmonary Consumption [description not available]	2.03	1	0
Tuberculosis, Pulmonary MYCOBACTERIUM infections of the lung.	2.03	1	0
Infections, Pseudomonas [description not available]	1.95	1	0
Pseudomonas Infections Infections with bacteria of the genus PSEUDOMONAS.	1.95	1	0
African Sleeping Sickness [description not available]	1.96	1	0
Trypanosomiasis, Bovine Infection in cattle caused by various species of trypanosomes.	1.96	1	0
Trypanosomiasis, African A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.	1.96	1	0
Pus [description not available]	1.96	1	0
Infection, Wound [description not available]	1.96	1	0
Phlegmon [description not available]	1.96	1	0
Infant, Newborn, Diseases Diseases of newborn infants present at birth (congenital) or developing within the first month of birth. It does not include hereditary diseases not manifesting at birth or within the first 30 days of life nor does it include inborn errors of metabolism. Both HEREDITARY DISEASES and METABOLISM, INBORN ERRORS are available as general concepts.	1.96	1	0
Staphylococcal Pneumonia [description not available]	1.96	1	0
Acute Disease Disease having a short and relatively severe course.	3.06	5	0
Cellulitis An acute, diffuse, and suppurative inflammation of loose connective tissue, particularly the deep subcutaneous tissues, and sometimes muscle, which is most commonly seen as a result of infection of a wound, ulcer, or other skin lesions.	1.96	1	0
Osteomyelitis INFLAMMATION of the bone as a result of infection. It may be caused by a variety of infectious agents, especially pyogenic (PUS - producing) BACTERIA.	1.96	1	0
Pneumonia, Staphylococcal Pneumonia caused by infections with bacteria of the genus STAPHYLOCOCCUS, usually with STAPHYLOCOCCUS AUREUS.	1.96	1	0
Empyema, Gall Bladder [description not available]	1.96	1	0
Erosive Duodenitis [description not available]	1.96	1	0
Cholangitis Inflammation of the biliary ductal system (BILE DUCTS); intrahepatic, extrahepatic, or both.	1.96	1	0
Cholecystitis Inflammation of the GALLBLADDER; generally caused by impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, or other diseases.	1.96	1	0
Duodenitis Inflammation of the DUODENUM section of the small intestine (INTESTINE, SMALL). Erosive duodenitis may cause bleeding in the UPPER GI TRACT and PEPTIC ULCER.	6.96	1	0
Gastritis Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders.	6.96	1	0
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	1.98	1	0
Pericementitis [description not available]	2.4	2	0
Periodontitis Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)	2.4	2	0
Innate Inflammatory Response [description not available]	3.37	1	1
Male Genitourinary Diseases [description not available]	3.37	1	1
Female Genitourinary Diseases [description not available]	3.37	1	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	3.37	1	1
Primary Peritonitis [description not available]	2.38	2	0
Peritonitis INFLAMMATION of the PERITONEUM lining the ABDOMINAL CAVITY as the result of infectious, autoimmune, or chemical processes. Primary peritonitis is due to infection of the PERITONEAL CAVITY via hematogenous or lymphatic spread and without intra-abdominal source. Secondary peritonitis arises from the ABDOMINAL CAVITY itself through RUPTURE or ABSCESS of intra-abdominal organs.	2.38	2	0
Chronic Illness [description not available]	2.9	4	0
Curling Ulcer Acute stress DUODENAL ULCER, usually observed in patients with extensive third-degree burns.	1.99	1	0
Gastric Ulcer [description not available]	1.99	1	0
Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	2.9	4	0
Duodenal Ulcer A PEPTIC ULCER located in the DUODENUM.	1.99	1	0
Stomach Ulcer Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).	1.99	1	0
Gingivitis Inflammation of gum tissue (GINGIVA) without loss of connective tissue.	2	1	0
Experimental Lung Inflammation Inflammation of any part, segment or lobe, of the lung parenchyma.	1.95	1	0
Alveolitis, Fibrosing [description not available]	1.95	1	0
Pneumonia Infection of the lung often accompanied by inflammation.	6.95	1	0
Pneumonia, Pneumococcal A febrile disease caused by STREPTOCOCCUS PNEUMONIAE.	1.95	1	0
Pulmonary Fibrosis A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.	1.95	1	0
Gastroduodenal Ulcer [description not available]	1.98	1	0
Peptic Ulcer Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).	6.98	1	0
Cerebral Arteriosclerosis [description not available]	1.98	1	0
Intracranial Arteriosclerosis Vascular diseases characterized by thickening and hardening of the walls of ARTERIES inside the SKULL. There are three subtypes: (1) atherosclerosis with fatty deposits in the ARTERIAL INTIMA; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include HEADACHE; CONFUSION; transient blindness (AMAUROSIS FUGAX); speech impairment; and HEMIPARESIS.	1.98	1	0
Infections, Staphylococcal [description not available]	2.38	2	0
Infection, Postoperative Wound [description not available]	1.98	1	0
Staphylococcal Infections Infections with bacteria of the genus STAPHYLOCOCCUS.	2.38	2	0
Injuries, Radiation [description not available]	1.97	1	0
Cancer of Rectum [description not available]	1.97	1	0
Rectal Neoplasms Tumors or cancer of the RECTUM.	1.97	1	0
Arteriosclerosis Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.	1.97	1	0
Caries, Dental [description not available]	2.37	2	0
Dental Caries Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic structures and leading to cavity formation. If left unchecked, the cavity may penetrate the enamel and dentin and reach the pulp.	2.37	2	0
Bronchitis Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCHI.	1.96	1	0

ethonium

Description

Cross-References

Synonyms (15)

Research Excerpts

Overview

Actions

Compound-Compound Interactions

Dosage Studied

Research

Studies (37)

Market Indicators

Research Demand Index: 21.53

Study Types

ethonium

Description

Cross-References

Synonyms (15)

Research Excerpts

Overview

Actions

Compound-Compound Interactions

Dosage Studied

Research

Studies (37)

Market Indicators

Research Demand Index: 21.53

Study Types

Related Drugs (21)

Related Conditions (57)