Page last updated: 2024-12-05

elymoclavine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

elymoclavine: ergot alkaloid isolated from cultures of fungi parasitic on Elymis mollis Trin; toxic alkaloid produced by Claviceps purpurea; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID440904
CHEMBL ID3706997
CHEBI ID4777
SCHEMBL ID183704
MeSH IDM0050876

Synonyms (22)

Synonym
5lr46dlo0d ,
unii-5lr46dlo0d
4-23-00-02716 (beilstein handbook reference)
einecs 208-948-9
8,9-didehydro-6-methylergoline-8-methanol
nsc 109431
brn 0030650
methanol, (8,9-didehydro-6-methylergolin-8-yl)-
SPECTRUM5_001634 ,
548-43-6
elymoclavine
C06068
SPECTRUM1800052
SCHEMBL183704
elymoclavine [mi]
CHEMBL3706997
CHEBI:4777
Q5368476
DTXSID70970145
((6ar,10ar)-7-methyl-4,6,6a,7,8,10a-hexahydroindolo[4,3-fg]quinolin-9-yl)methanol
[(6ar,10ar)-7-methyl-6,6a,8,10a-tetrahydro-4h-indolo[4,3-fg]quinolin-9-yl]methanol
[(2r,7r)-6-methyl-6,11-diazatetracyclo[7.6.1.0?,?.0??,??]hexadeca-1(16),3,9,12,14-pentaen-4-yl]methanol
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
alkaloidAny of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID1123660Inhibition of prolactin release in rat at 10 ug relative to control1979Journal of medicinal chemistry, Jan, Volume: 22, Issue:1
Ergot alkaloids. Synthesis of nitrosourea derivatives of ergolines as potential anticancer agents.
AID1149978Prolactin inhibition ability in Sprague-Dawley rat at 10 ug/ml, ip administered 18 hrs post reserpine treatment measured after 1 hr by RIA relative to ergoconine1977Journal of medicinal chemistry, Nov, Volume: 20, Issue:11
Ergot alkaloids. Synthesis of 6-alkyl-8-ergolenes and 6-methyl-8-aminoergolines as potential prolactin inhibitors.
AID1149977Prolactin inhibition ability in Sprague-Dawley rat at 10 ug/ml, ip administered 18 hrs post reserpine treatment measured after 1 hr by RIA1977Journal of medicinal chemistry, Nov, Volume: 20, Issue:11
Ergot alkaloids. Synthesis of 6-alkyl-8-ergolenes and 6-methyl-8-aminoergolines as potential prolactin inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (24)

TimeframeStudies, This Drug (%)All Drugs %
pre-199018 (75.00)18.7374
1990's4 (16.67)18.2507
2000's1 (4.17)29.6817
2010's1 (4.17)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other26 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]