Page last updated: 2024-11-10

lr 16

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

LR 16: structure given in first source; has potent effects on oxygen affinity of hemoglobin, on blood cholesterol and on low density lipoprotein [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID3082814
CHEMBL ID77193
SCHEMBL ID1304565
MeSH IDM0159458

Synonyms (12)

Synonym
CHEMBL77193
117011-50-4
lr16
lr-16
propanoic acid, 2-(4-((((3,4-dichlorophenyl)amino)carbonyl)amino)phenoxy)-2-methyl-
2-(4-(3,4-dichlorophenylureido)phenoxy)-2-methylpropionic acid
lr 16
2-[4-[(3,4-dichlorophenyl)carbamoylamino]phenoxy]-2-methylpropanoic acid
SCHEMBL1304565
DTXSID60151668
2-(4-(3-(3,4-dichlorophenyl)ureido)phenoxy)-2-methylpropanoic acid
AKOS040752687
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID231976Ratio of effect of compound on affinity of hemoglobin for oxygen to that of control1989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
Synthesis and investigation of effects of 2-[4- [[(arylamino)carbonyl]amino]phenoxy]-2-methylpropionic acids on the affinity of hemoglobin for oxygen: structure-activity relationships.
AID92892Ability of 0.2 mM to reduce affinity of hemoglobin for oxygen is assessed from 50% partial pressure of oxygen in intact red cells1989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
Synthesis and investigation of effects of 2-[4- [[(arylamino)carbonyl]amino]phenoxy]-2-methylpropionic acids on the affinity of hemoglobin for oxygen: structure-activity relationships.
AID221788Ability of 0.2 mM to reduce affinity of hemoglobin for oxygen is assessed from 50% partial pressure of oxygen in membrane free hemoglobin solution1989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
Synthesis and investigation of effects of 2-[4- [[(arylamino)carbonyl]amino]phenoxy]-2-methylpropionic acids on the affinity of hemoglobin for oxygen: structure-activity relationships.
AID226490Oxygen pressure in mmHg at which the control hemoglobin solution (in presence of 10 mM compound) was 50% saturated with oxygen.1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
Allosteric modifiers of hemoglobin. 1. Design, synthesis, testing, and structure-allosteric activity relationship of novel hemoglobin oxygen affinity decreasing agents.
AID226489Oxygen pressure in mmHg at which the control hemoglobin solution (no compound) was 50% saturated with oxygen.1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
Allosteric modifiers of hemoglobin. 1. Design, synthesis, testing, and structure-allosteric activity relationship of novel hemoglobin oxygen affinity decreasing agents.
AID221789Ability of 0.5 mM to reduce affinity of hemoglobin for oxygen is assessed from 50% partial pressure of oxygen in membrane free hemoglobin solution1989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
Synthesis and investigation of effects of 2-[4- [[(arylamino)carbonyl]amino]phenoxy]-2-methylpropionic acids on the affinity of hemoglobin for oxygen: structure-activity relationships.
AID226491Allosteric activity evaluated as the ratio of the oxygen pressure in mmHg between hemoglobin-compound and compound-free hemoglobin (control) solution at which 50% oxygen saturation's are respectively attained.1991Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
Allosteric modifiers of hemoglobin. 2. Crystallographically determined binding sites and hydrophobic binding/interaction analysis of novel hemoglobin oxygen effectors.
AID93011Ability of 0.5 mM to reduce affinity of hemoglobin for oxygen is assessed from 50% partial pressure of oxygen in intact red cells1989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
Synthesis and investigation of effects of 2-[4- [[(arylamino)carbonyl]amino]phenoxy]-2-methylpropionic acids on the affinity of hemoglobin for oxygen: structure-activity relationships.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (33.33)18.7374
1990's4 (66.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 33.84

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index33.84 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.62 (4.65)
Search Engine Demand Index53.50 (26.88)
Search Engine Supply Index2.68 (0.95)

This Compound (33.84)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]