Page last updated: 2024-12-10
lr 16
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
LR 16: structure given in first source; has potent effects on oxygen affinity of hemoglobin, on blood cholesterol and on low density lipoprotein [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 3082814 |
| CHEMBL ID | 77193 |
| SCHEMBL ID | 1304565 |
| MeSH ID | M0159458 |
Synonyms (12)
| Synonym |
|---|
| CHEMBL77193 |
| 117011-50-4 |
| lr16 |
| lr-16 |
| propanoic acid, 2-(4-((((3,4-dichlorophenyl)amino)carbonyl)amino)phenoxy)-2-methyl- |
| 2-(4-(3,4-dichlorophenylureido)phenoxy)-2-methylpropionic acid |
| lr 16 |
| 2-[4-[(3,4-dichlorophenyl)carbamoylamino]phenoxy]-2-methylpropanoic acid |
| SCHEMBL1304565 |
| DTXSID60151668 |
| 2-(4-(3-(3,4-dichlorophenyl)ureido)phenoxy)-2-methylpropanoic acid |
| AKOS040752687 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (8)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID231976 | Ratio of effect of compound on affinity of hemoglobin for oxygen to that of control | 1989 | Journal of medicinal chemistry, Oct, Volume: 32, Issue:10 | Synthesis and investigation of effects of 2-[4- [[(arylamino)carbonyl]amino]phenoxy]-2-methylpropionic acids on the affinity of hemoglobin for oxygen: structure-activity relationships. |
| AID92892 | Ability of 0.2 mM to reduce affinity of hemoglobin for oxygen is assessed from 50% partial pressure of oxygen in intact red cells | 1989 | Journal of medicinal chemistry, Oct, Volume: 32, Issue:10 | Synthesis and investigation of effects of 2-[4- [[(arylamino)carbonyl]amino]phenoxy]-2-methylpropionic acids on the affinity of hemoglobin for oxygen: structure-activity relationships. |
| AID221788 | Ability of 0.2 mM to reduce affinity of hemoglobin for oxygen is assessed from 50% partial pressure of oxygen in membrane free hemoglobin solution | 1989 | Journal of medicinal chemistry, Oct, Volume: 32, Issue:10 | Synthesis and investigation of effects of 2-[4- [[(arylamino)carbonyl]amino]phenoxy]-2-methylpropionic acids on the affinity of hemoglobin for oxygen: structure-activity relationships. |
| AID226490 | Oxygen pressure in mmHg at which the control hemoglobin solution (in presence of 10 mM compound) was 50% saturated with oxygen. | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Allosteric modifiers of hemoglobin. 1. Design, synthesis, testing, and structure-allosteric activity relationship of novel hemoglobin oxygen affinity decreasing agents. |
| AID226489 | Oxygen pressure in mmHg at which the control hemoglobin solution (no compound) was 50% saturated with oxygen. | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Allosteric modifiers of hemoglobin. 1. Design, synthesis, testing, and structure-allosteric activity relationship of novel hemoglobin oxygen affinity decreasing agents. |
| AID221789 | Ability of 0.5 mM to reduce affinity of hemoglobin for oxygen is assessed from 50% partial pressure of oxygen in membrane free hemoglobin solution | 1989 | Journal of medicinal chemistry, Oct, Volume: 32, Issue:10 | Synthesis and investigation of effects of 2-[4- [[(arylamino)carbonyl]amino]phenoxy]-2-methylpropionic acids on the affinity of hemoglobin for oxygen: structure-activity relationships. |
| AID226491 | Allosteric activity evaluated as the ratio of the oxygen pressure in mmHg between hemoglobin-compound and compound-free hemoglobin (control) solution at which 50% oxygen saturation's are respectively attained. | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2 | Allosteric modifiers of hemoglobin. 2. Crystallographically determined binding sites and hydrophobic binding/interaction analysis of novel hemoglobin oxygen effectors. |
| AID93011 | Ability of 0.5 mM to reduce affinity of hemoglobin for oxygen is assessed from 50% partial pressure of oxygen in intact red cells | 1989 | Journal of medicinal chemistry, Oct, Volume: 32, Issue:10 | Synthesis and investigation of effects of 2-[4- [[(arylamino)carbonyl]amino]phenoxy]-2-methylpropionic acids on the affinity of hemoglobin for oxygen: structure-activity relationships. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (6)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 33.84
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (33.84) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||