| Assay ID | Title | Year | Journal | Article |
|---|
| AID1832399 | Inhibition of Sprague-Dawley rat spleen microsome HO-1 assessed as bilirubin formation incubated for 60 mins by double-beam spectrophotometry | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
| Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent |
| AID241716 | In vitro inhibitory concentration against heme oxygenase 1 from rat spleen | 2005 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 15, Issue:5
| Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors. |
| AID54200 | Binding affinity for Cytochrome P450 19A1 | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
| AID85689 | Percentage lowering of the total serum cholesterol in male hamsters at a dose of 10 mg/dL orally administered for 14 days | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
| AID287885 | Inhibition of Sprague-Dawley rat spleen microsome HO1 | 2007 | Bioorganic & medicinal chemistry, May-01, Volume: 15, Issue:9
| Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: effect of halogen substitution in the phenyl ring. |
| AID86732 | Inhibition of lanosterol 14-alpha-demethylation in hepatic microsomes from human | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
| AID85818 | Percentage lowering of the total serum cholesterol in male hamsters at a dose of 50 mg/dL orally administered for 14 days | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
| AID267292 | Inhibition of Sprague-Dawley rat spleen HO1 | 2006 | Journal of medicinal chemistry, Jul-13, Volume: 49, Issue:14
| Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors. |
| AID85817 | Percentage lowering of the total serum cholesterol in male hamsters at a dose of 5 mg/dL orally administered for 14 days | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
| AID287886 | Inhibition of Sprague-Dawley rat brain microsome HO2 | 2007 | Bioorganic & medicinal chemistry, May-01, Volume: 15, Issue:9
| Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: effect of halogen substitution in the phenyl ring. |
| AID287887 | Selectivity index, ratio of IC50 for Sprague-Dawley rat brain HO2 to IC50 for Sprague-Dawley rat spleen HO1 | 2007 | Bioorganic & medicinal chemistry, May-01, Volume: 15, Issue:9
| Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: effect of halogen substitution in the phenyl ring. |
| AID1832398 | Inhibition of Sprague-Dawley rat brain microsome HO-2 assessed as bilirubin formation incubated for 60 mins by double-beam spectrophotometry | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
| Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent |
| AID83865 | Effect on total serum cholesterol in male hamsters at a dose of 50 mg/kg orally administered for 14 days | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
| AID1353892 | Inhibition of HO-2 in Sprague-Dawley albino rat brain microsomes assessed as reduction in bilirubin formation using hemin as substrate after 60 mins in presence of NADPH by biliverdin reductase enzyme coupled spectrophotometric assay | 2018 | European journal of medicinal chemistry, Mar-25, Volume: 148 | Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors. |
| AID1422093 | Inhibition of heme oxygenase 1 in Sprague-Dawley rat spleen microsomal fraction assessed as decrease in bilirubin formation using biliverdin reductase as substrate after 60 mins by spectrophotometric method | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines. |
| AID85816 | Percentage lowering of the total serum cholesterol in male hamsters at a dose of 30 mg/dL orally administered for 3 days | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
| AID1353891 | Inhibition of HO-1 in Sprague-Dawley albino rat spleen microsomes assessed as reduction in bilirubin formation using hemin as substrate after 60 mins in presence of NADPH by biliverdin reductase enzyme coupled spectrophotometric assay | 2018 | European journal of medicinal chemistry, Mar-25, Volume: 148 | Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors. |
| AID244387 | Relative binding affinity to rat heme oxygenases 1 and 2 | 2005 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 15, Issue:5
| Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors. |
| AID51047 | Binding affinity for corticoid 11-beta-hydroxylase | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
| AID51625 | Binding affinity for cholesterol 17-alpha-hydroxylase | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
| AID1832401 | Selectivity index, ratio of IC50 for inhibition of Sprague-Dawley rat brain microsome HO-2 to IC50 for inhibition of Sprague-Dawley rat spleen microsome HO-1 | 2021 | Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
| Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent |
| AID83862 | Effect on total serum cholesterol in male hamsters at a dose of 25 mg/kg orally administered for 14 days | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
| AID764734 | Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysis | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17
| Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties. |
| AID267293 | Inhibition of Sprague-Dawley rat brain HO2 | 2006 | Journal of medicinal chemistry, Jul-13, Volume: 49, Issue:14
| Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors. |
| AID83857 | Effect on total serum cholesterol in male hamsters at a dose of 10 mg/kg orally administered for 3 days | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
| AID83863 | Effect on total serum cholesterol in male hamsters at a dose of 30 mg/kg orally administered for 3 days | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
| AID89415 | Inhibition of cellular cholesterol biosynthesis using human fibroblasts in tissue culture | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
| AID85815 | Percentage lowering of the total serum cholesterol in male hamsters at a dose of 25 mg/dL orally administered for 14 days | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
| AID161642 | Binding affinity for progesterone 6-beta-hydroxylase of hepatic microsomes | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
| AID83856 | Effect on total serum cholesterol in male hamsters at a dose of 10 mg/kg orally administered for 14 days | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
| AID86733 | Inhibition of lanosterol 14-alpha-demethylation in hepatic microsomes from rat | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
| AID83864 | Effect on total serum cholesterol in male hamsters at a dose of 5 mg/kg orally administered for 14 days | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
| AID1353893 | Selectivity index, ratio of IC50 for HO-2 in Sprague-Dawley albino rat brain microsomes to IC50 for HO-1 in Sprague-Dawley albino rat spleen microsomes | 2018 | European journal of medicinal chemistry, Mar-25, Volume: 148 | Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors. |
| AID85690 | Percentage lowering of the total serum cholesterol in male hamsters at a dose of 10 mg/dL orally administered for 3 days | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
| AID764735 | Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis | 2013 | Bioorganic & medicinal chemistry, Sep-01, Volume: 21, Issue:17
| Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties. |
| AID86731 | Inhibition of lanosterol 14-alpha-demethylation in hepatic microsomes from hamster | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
| AID83859 | Effect on total serum cholesterol in male hamsters at a dose of 100 mg/kg orally administered for 3 days | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
| AID241681 | In vitro inhibitory concentration against heme oxygenase 2 from rat brain | 2005 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 15, Issue:5
| Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors. |
| AID267294 | Selectivity index, rat HO2/HO1 | 2006 | Journal of medicinal chemistry, Jul-13, Volume: 49, Issue:14
| Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors. |
| AID85812 | Percentage lowering of the total serum cholesterol in male hamsters at a dose of 100 mg/dL orally administered for 3 days | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
| AID161640 | Binding affinity for progesterone 17-alpha,20-lyase | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
| AID1345280 | Human CYP19A1 (CYP11, CYP17, CYP19, CYP20 and CYP21 families) | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
| AID1345279 | Human CYP51A1 (CYP39, CYP46 and CYP51 families) | 1993 | Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
| Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |