4,4-dimethylcholesta-8,14-dien-3-ol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4,4-dimethylcholesta-8,14-dien-3-ol: RN refers to (3beta,5alpha)-isomer; a meiosis-activating sterol [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

4,4-dimethyl-8,14-cholestadien-3beta-ol : A cholestanoid that is 5alpha-cholesta-8,14-dien-3beta-ol bearing two additional methyl substituents at position 4. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	167817
CHEBI ID	78904
SCHEMBL ID	6407395
MeSH ID	M0194974

Synonyms (26)

Synonym
cholesta-8,14-dien-3-ol, 4,4-dimethyl-, (3beta,5alpha)-
19456-83-8
(3s,5r,10s,13r,17r)-4,4,10,13-tetramethyl-17-[(2r)-6-methylheptan-2-yl]-1,2,3,5,6,7,11,12,16,17-decahydrocyclopenta[a]phenanthren-3-ol
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol
LMST01010277
4,4-dimethyl-5alpha-cholesta-8,14-diene-3beta-ol
4,4-dcdo
4,4-dimethylcholesta-8,14-dien-3-ol
CHEBI:78904
(3beta,5alpha)-4,4-dimethylcholesta-8,14-dien-3-ol
4,4-dimethyl-8,14-cholestadien-3beta-ol
SCHEMBL6407395
cholesta-8,14-dien-3-ol, 4,4-dimethyl-, (3.beta.,5.alpha.)-
5.alpha.-cholesta-8,14-dien-3.beta.-ol, 4,4-dimethyl-,acetate
5.alpha.-cholesta-8,14-dien-3.beta.-ol, 4,4-dimethyl-
cholesta-8,14-dien-3-ol, 4,4-dimethyl-, (3.beta.,5.alpha.)-acetate
4,4-dimethylcholesta-8,14-dien-3-ol #
OGQJUYXFIOFTMA-PBJLWWPKSA-N
4,4-dimethyl-5a-cholesta-8,14-dien-3b-ol
(3b,5a)-4,4-dimethylcholesta-8,14-dien-3-ol
4,4-dimethyl-5 alpha-cholesta-8,14-diene-3 beta-ol
4,4-dimethylcholesta-8,14-dien-3-ol, (3beta)-isomer
t-mas
4,4-dimethyl-5a-cholesta-8,14-diene-3b-ol
Q27148018
DTXSID40941201

Research Excerpts

Dosage Studied

Excerpt	Relevance	Reference
" The ovarian 4,4-dimethylsterol response was followed with regard to time and dose-response to the gonadotropins and the resumption of meiosis was evaluated using histologic sections."	( Gonadotropin-induced accumulation of 4,4-dimethylsterols in mouse ovaries and its temporal relation to meiosis. Baltsen, M, 2001)	0.31

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (3)

Class	Description
3beta-sterol	A sterol in which the hydroxy group at position 3 has beta- configuration.
cholestanoid	Any steroid based on a cholestane skeleton and its derivatives.
tetracyclic triterpenoid	Any triterpenoid consisting of a tetracyclic skeleton.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (4)

Pathway	Proteins	Compounds
Kandutsch-Russell Pathway (Cholesterol Biosynthesis)	9	30
Cholesterol biosynthesis pathway in hepatocytes	11	37
cholesterol biosynthesis II (via 24,25-dihydrolanosterol)	9	37
superpathway of cholesterol biosynthesis	21	78

Research

Studies (10)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (10.00)	18.2507
2000's	9 (90.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.42

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.42 (24.57)
Research Supply Index	2.40 (2.92)
Research Growth Index	4.82 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.42)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
amitrole Amitrole: A non-selective post-emergence, translocated herbicide. According to the Seventh Annual Report on Carcinogens (PB95-109781, 1994) this substance may reasonably be anticipated to be a carcinogen. (From Merck Index, 12th ed) It is an irreversible inhibitor of CATALASE, and thus impairs activity of peroxisomes.. amitrole : A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.	1.97	1	aromatic amine; triazoles	carotenoid biosynthesis inhibitor; EC 1.11.1.6 (catalase) inhibitor; herbicide
pd 98059 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source. 2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.	2	1	aromatic amine; monomethoxyflavone	EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; geroprotector
trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride: An anti-cholesteremic agent that inhibits delta 7-reductase, delta 14 reductase, and sterol biosynthesis.	2.03	1
azalanstat azalanstat: inhibits lanosterol 14 alpha-demethylase, the enzyme which catalyzes the first step in conversion of lanosterol to cholesterol in mammals; structure given in first source	2.03	1
lanosterol [no description available]	2.92	4	14alpha-methyl steroid; 3beta-sterol; tetracyclic triterpenoid	bacterial metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
mevalonic acid Mevalonic Acid: A dihydroxy monocarboxylic acid and precursor in the biosynthetic pathway known as the mevalonate pathway, which produces terpenes and steroids that are vital for diverse cellular functions.. mevalonic acid : A racemate composed of equimolar amounts of (R)- and (S)-mevalonic acid.. (R)-mevalonic acid : The (R)-enantiomer of mevalonic acid.	1.97	1	3,5-dihydroxy-3-methylpentanoic acid
4,4-dimethylcholesta-8,14,24-trienol 4,4-dimethylcholesta-8,14,24-trienol: a meiosis activating sterol; RN given refers to (5alpha,3beta)-isomer	3.26	6	3beta-sterol; Delta(14) steroid	human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
adenosine-3',5'-cyclic phosphorothioate adenosine-3',5'-cyclic phosphorothioate: RP-cAMP-S is a protein kinase A inhibitor; SP-cAMP-S is a protein kinase A agonist. (Sp)-cAMPS : A nucleoside 3',5'-cyclic phosphorothioate having adenine as the nucleobase (the Sp-stereoisomer).. (Rp)-cAMPS : A nucleoside 3',5'-cyclic phosphorothioate having adenine as the nucleobase (the Rp-stereoisomer).	2	1	nucleoside 3',5'-cyclic phosphorothioate
menotropins Menotropins: Extracts of urine from menopausal women that contain high concentrations of pituitary gonadotropins, FOLLICLE STIMULATING HORMONE and LUTEINIZING HORMONE. Menotropins are used to treat infertility. The FSH:LH ratio and degree of purity vary in different preparations.	2	1
4-methylcholest-7-en-3-ol 4-methylcholest-7-en-3-ol: RN given refers to (3beta,4alpha,5alpha)-isomer	1.97	1
hypoxanthine [no description available]	2	1	nucleobase analogue; oxopurine; purine nucleobase	fundamental metabolite

Condition	Relationship Strength	Studies
Polycystic Ovarian Syndrome [description not available]	2.03	1
Polycystic Ovary Syndrome A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading.	2.03	1
Abdominal Cryptorchidism [description not available]	2	1
Equine Diseases [description not available]	2	1
Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	2	1

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