Compounds > 1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1h)-one
Page last updated: 2024-09-26

1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1h)-one

Description

1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one: used to oxidize primary alcohols to aldehydes and secondary alcohols to ketones; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID159087
CHEMBL ID116656
SCHEMBL ID3746862
SCHEMBL ID62879
SCHEMBL ID1999537
MeSH IDM0502350

Synonyms (88)

Synonym
bdbm50075026
acetic acid 1,1-diacetoxy-3-oxo-1lambda*5*-ioda-2-oxa-indan-1-yl ester
dess-martin periodinane, 97%
dess-martin periodinane
87413-09-0
CHEMBL116656 ,
AKOS005146141
SCHEMBL3746862
D2045
1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1h)-one
1,1-dihydro-1,1,1-triacetoxy-1,2-benzoiodooxol-3(1h)-one
desss-martin periodinane
dess martin periodinane
1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3-(1h)-one
dess martin
1,1,1-tris(acetyloxy)-1,1-dihydro-1,2-benziodoxol-3(1h)-one
dess-martin reagent
(7,7-diacetyloxy-9-oxo-7lambda(5)-ioda-8-oxabicyclo[
acetic acid 1,1-diacetoxy-3-oxo-1l5-ioda-2-oxa-indan-1-yl ester
1,1,1-tris(acetyloxy)-1,1-dihydro-1,2-benziodoxol-3-(1h)-one
triacetoxyperiodinane
unii-336b74jk56
336b74jk56 ,
1,2-benziodoxol-3(1h)-one, 1,1,1-tris(acetyloxy)-1,1-dihydro-
1,1-dihydro-1,1,1-triacetoxy-1,2-benziodoxol-3(1h)-one
dess-martinperiodinane
BP-20360
FT-0602194
AB03686
dess-martin periodane
SCHEMBL62879
SCHEMBL1999537
reagents, martin's
dess-martin periodinane [mi]
martin's reagent
acetic acid 1,1',1''-(3-oxo-1.lambda.5-1,2-benziodoxol-1(3h)-ylidyne) ester
acetic acid, 1,1',1''-(3-oxo-1.lambda.5-1,2-benziodoxol-1(3h)-ylidyne) ester
dessmartin's periodinane
dessmartin periodinane
des s-martin periodinane
dess martin reagent
1,1,1-triacetoxy-1, 1-dihydro-1,2-benziodoxol-3(1h)-one
1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxyl-3 (1h)-one
1,1, 1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1h)-one
1,1,1 -triacetoxy-1,1 -dihydro-1,2-benziodoxyl-3(1h)-one
dess martin's reagent
dess-martin's reagent
1,1,1-tris(acetyloxy)-1lambda5,2-benziodoxol-3(1h)-one
1,1,1-tris(acetyloxy)-1,1-dihydro-1,2-benziodoxol-3-(1 h)-one
1,1,1-tris(acetyloxy)-1,1-dihydro-1,2-benziodoxol-3-(1h)-on e
dess -martin periodinane
1,1,1-tri acetoxy-1,1-dihydro-1,2-benziodoxol-3(1h)-one
NKLCNNUWBJBICK-UHFFFAOYSA-N
1,1,1-tris (acetyloxy)-1,1-dihydro-1,2-benziodoxol-3-(1h)-on e
acetic acid 1,1-diacetoxy-3-oxo-1lambda5-ioda-2-oxa-indan-1-yl ester
dess_martin periodinane
triacetoxy periodinane
(1,1,1-triacetoxy)-1,1-dihydro-1,2-benziodoxol-3(1h)-one
1,1,1 triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1h)-one
dess--martin periodinane
dess-martin periodine
1,1,1-tris(actyloxy)-1,1-dihydro-1,2-benziodoxol-3-(1h)-one
1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxyl-3(1h)-one
dess-martin
dess-martine periodinane
1,1,1-tris(acetyloxy)-1lambda5, 2-benziodoxol-3(1h)-on
1.1.1-triacetoxy-1.1-dihydro-1.2-benziodoxol-3-(1h)-one
1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3 (1h)-one
1,1,1-triacetoxy-1lambda5,2-benziodoxol-3(1h)-one
1,1,1-tris(acetyloxy)-1,1-dihydro-1, 2-benziodoxol-3(1h)-one
1,1,1-tris(acetyloxy)-1lambda~5~,2-benziodoxol-3(1h)-one
3-oxo-1l5-benzo[d][1,2]iodaoxole-1,1,1(3h)-triyl triacetate
AC-28729
D4477
mfcd00130127
dess-martin reactant
F0001-2178
1,1-bis(acetyloxy)-3-oxo-3h-1??,2-benziodaoxol-1-yl acetate
DTXSID30236335
GS-6909
1,1-bis(acetyloxy)-3-oxo-3h-1lambda5,2-benziodaoxol-1-yl acetate
CS-0020511
Q420909
BCP09374
AMY4130
(1,1-diacetyloxy-3-oxo-1lambda5,2-benziodoxol-1-yl) acetate
dess-martin periodinane (technical grade)
1,1-bis(acetyloxy)-3-oxo-3h-1,2-benziodaoxol-1-yl acetate

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)IC50 (µMol)130.00000.00053.49849.7600AID164835
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (27)

Processvia Protein(s)Taxonomy
positive regulation of JUN kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein dephosphorylationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of signal transductionTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of signal transductionTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
actin cytoskeleton organizationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of endocytosisTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of vascular endothelial growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulum unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of intracellular protein transportTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cellular response to unfolded proteinTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
peptidyl-tyrosine dephosphorylationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
platelet-derived growth factor receptor-beta signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
IRE1-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor recyclingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of MAP kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of insulin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of type I interferon-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
growth hormone receptor signaling pathway via JAK-STATTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of protein tyrosine kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascadeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of hepatocyte growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of IRE1-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of PERK-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of receptor catabolic processTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (12)

Processvia Protein(s)Taxonomy
RNA bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
zinc ion bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
enzyme bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein kinase bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
receptor tyrosine kinase bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cadherin bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
ephrin receptor bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein phosphatase 2A bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
non-membrane spanning protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (11)

Processvia Protein(s)Taxonomy
plasma membraneTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
mitochondrial matrixTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
early endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulumTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytosolTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
mitochondrial cristaTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endosome lumenTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
sorting endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmic side of endoplasmic reticulum membraneTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein-containing complexTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulumTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
early endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID223686Inhibition of protein tyrosine phosphatase (PTP) activity in rat liver endosome insulin receptor (IR) dephosphorylation assay at 0.1 mM1999Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
Periodinates: a new class of protein tyrosine phosphatase inhibitors.
AID223687Inhibition of protein tyrosine phosphatase (PTP) activity in rat liver endosome insulin receptor (IR) dephosphorylation assay at 1 mM1999Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
Periodinates: a new class of protein tyrosine phosphatase inhibitors.
AID164835Inhibition of protein tyrosine phosphatase 1B (PTP1B) activity in 3,6-fluorescein diphosphate (FDP) assay1999Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
Periodinates: a new class of protein tyrosine phosphatase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's1 (16.67)29.6817
2010's2 (33.33)24.3611
2020's2 (33.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
o-iodoxybenzoic acid[no description available]medium10benziodoxoleEC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor;
oxidising agent
potassium thiocyanate[no description available]medium10potassium salt
thiazoles[no description available]medium101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
lycorine[no description available]medium10indolizidine alkaloidanticoronaviral agent;
antimalarial;
plant metabolite;
protein synthesis inhibitor
urea[no description available]medium10isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
carbamates[no description available]medium10amino-acid anion
ConditionIndicatedRelationship StrengthStudiesTrials