Compounds > 1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1h)-one
Page last updated: 2024-12-08

1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1h)-one

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Description

1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one: used to oxidize primary alcohols to aldehydes and secondary alcohols to ketones; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID159087
CHEMBL ID116656
SCHEMBL ID3746862
SCHEMBL ID62879
SCHEMBL ID1999537
MeSH IDM0502350

Synonyms (88)

Synonym
bdbm50075026
acetic acid 1,1-diacetoxy-3-oxo-1lambda*5*-ioda-2-oxa-indan-1-yl ester
dess-martin periodinane, 97%
dess-martin periodinane
87413-09-0
CHEMBL116656 ,
AKOS005146141
SCHEMBL3746862
D2045
1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1h)-one
1,1-dihydro-1,1,1-triacetoxy-1,2-benzoiodooxol-3(1h)-one
desss-martin periodinane
dess martin periodinane
1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3-(1h)-one
dess martin
1,1,1-tris(acetyloxy)-1,1-dihydro-1,2-benziodoxol-3(1h)-one
dess-martin reagent
(7,7-diacetyloxy-9-oxo-7lambda(5)-ioda-8-oxabicyclo[
acetic acid 1,1-diacetoxy-3-oxo-1l5-ioda-2-oxa-indan-1-yl ester
1,1,1-tris(acetyloxy)-1,1-dihydro-1,2-benziodoxol-3-(1h)-one
triacetoxyperiodinane
unii-336b74jk56
336b74jk56 ,
1,2-benziodoxol-3(1h)-one, 1,1,1-tris(acetyloxy)-1,1-dihydro-
1,1-dihydro-1,1,1-triacetoxy-1,2-benziodoxol-3(1h)-one
dess-martinperiodinane
BP-20360
FT-0602194
AB03686
dess-martin periodane
SCHEMBL62879
SCHEMBL1999537
reagents, martin's
dess-martin periodinane [mi]
martin's reagent
acetic acid 1,1',1''-(3-oxo-1.lambda.5-1,2-benziodoxol-1(3h)-ylidyne) ester
acetic acid, 1,1',1''-(3-oxo-1.lambda.5-1,2-benziodoxol-1(3h)-ylidyne) ester
dessmartin's periodinane
dessmartin periodinane
des s-martin periodinane
dess martin reagent
1,1,1-triacetoxy-1, 1-dihydro-1,2-benziodoxol-3(1h)-one
1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxyl-3 (1h)-one
1,1, 1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1h)-one
1,1,1 -triacetoxy-1,1 -dihydro-1,2-benziodoxyl-3(1h)-one
dess martin's reagent
dess-martin's reagent
1,1,1-tris(acetyloxy)-1lambda5,2-benziodoxol-3(1h)-one
1,1,1-tris(acetyloxy)-1,1-dihydro-1,2-benziodoxol-3-(1 h)-one
1,1,1-tris(acetyloxy)-1,1-dihydro-1,2-benziodoxol-3-(1h)-on e
dess -martin periodinane
1,1,1-tri acetoxy-1,1-dihydro-1,2-benziodoxol-3(1h)-one
NKLCNNUWBJBICK-UHFFFAOYSA-N
1,1,1-tris (acetyloxy)-1,1-dihydro-1,2-benziodoxol-3-(1h)-on e
acetic acid 1,1-diacetoxy-3-oxo-1lambda5-ioda-2-oxa-indan-1-yl ester
dess_martin periodinane
triacetoxy periodinane
(1,1,1-triacetoxy)-1,1-dihydro-1,2-benziodoxol-3(1h)-one
1,1,1 triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1h)-one
dess--martin periodinane
dess-martin periodine
1,1,1-tris(actyloxy)-1,1-dihydro-1,2-benziodoxol-3-(1h)-one
1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxyl-3(1h)-one
dess-martin
dess-martine periodinane
1,1,1-tris(acetyloxy)-1lambda5, 2-benziodoxol-3(1h)-on
1.1.1-triacetoxy-1.1-dihydro-1.2-benziodoxol-3-(1h)-one
1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3 (1h)-one
1,1,1-triacetoxy-1lambda5,2-benziodoxol-3(1h)-one
1,1,1-tris(acetyloxy)-1,1-dihydro-1, 2-benziodoxol-3(1h)-one
1,1,1-tris(acetyloxy)-1lambda~5~,2-benziodoxol-3(1h)-one
3-oxo-1l5-benzo[d][1,2]iodaoxole-1,1,1(3h)-triyl triacetate
AC-28729
D4477
mfcd00130127
dess-martin reactant
F0001-2178
1,1-bis(acetyloxy)-3-oxo-3h-1??,2-benziodaoxol-1-yl acetate
DTXSID30236335
GS-6909
1,1-bis(acetyloxy)-3-oxo-3h-1lambda5,2-benziodaoxol-1-yl acetate
CS-0020511
Q420909
BCP09374
AMY4130
(1,1-diacetyloxy-3-oxo-1lambda5,2-benziodoxol-1-yl) acetate
dess-martin periodinane (technical grade)
1,1-bis(acetyloxy)-3-oxo-3h-1,2-benziodaoxol-1-yl acetate
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)IC50 (µMol)130.00000.00053.49849.7600AID164835
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (27)

Processvia Protein(s)Taxonomy
positive regulation of JUN kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein dephosphorylationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of signal transductionTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of signal transductionTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
actin cytoskeleton organizationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of endocytosisTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of vascular endothelial growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulum unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of intracellular protein transportTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cellular response to unfolded proteinTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
peptidyl-tyrosine dephosphorylationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
platelet-derived growth factor receptor-beta signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
IRE1-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor recyclingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of MAP kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of insulin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of type I interferon-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
growth hormone receptor signaling pathway via JAK-STATTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of protein tyrosine kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascadeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of hepatocyte growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of IRE1-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of PERK-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of receptor catabolic processTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (12)

Processvia Protein(s)Taxonomy
RNA bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
zinc ion bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
enzyme bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein kinase bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
receptor tyrosine kinase bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cadherin bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
ephrin receptor bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein phosphatase 2A bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
non-membrane spanning protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (11)

Processvia Protein(s)Taxonomy
plasma membraneTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
mitochondrial matrixTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
early endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulumTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytosolTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
mitochondrial cristaTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endosome lumenTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
sorting endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmic side of endoplasmic reticulum membraneTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein-containing complexTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulumTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
early endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID223686Inhibition of protein tyrosine phosphatase (PTP) activity in rat liver endosome insulin receptor (IR) dephosphorylation assay at 0.1 mM1999Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
Periodinates: a new class of protein tyrosine phosphatase inhibitors.
AID223687Inhibition of protein tyrosine phosphatase (PTP) activity in rat liver endosome insulin receptor (IR) dephosphorylation assay at 1 mM1999Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
Periodinates: a new class of protein tyrosine phosphatase inhibitors.
AID164835Inhibition of protein tyrosine phosphatase 1B (PTP1B) activity in 3,6-fluorescein diphosphate (FDP) assay1999Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
Periodinates: a new class of protein tyrosine phosphatase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's1 (16.67)29.6817
2010's2 (33.33)24.3611
2020's2 (33.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.03

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.03 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.97 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.03)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
carbamates
[no description available]		2.0210amino-acid anion
urea
pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.		2.0210isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
thiazoles
[no description available]		2.41101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
lycorine
lycorine: from bulbs of LYCORIS & other plants; RN given refers to (1 alpha,2 beta)-isomer; structure in Merck Index, 9th ed, #5444. lycorine : An indolizidine alkaloid that is 3,12-didehydrogalanthan substituted by hydroxy groups at positions and 2 and a methylenedioxy group across positions 9 and 10. Isolated from Crinum asiaticum, it has been shown to exhibit antimalarial activity.		2.1310indolizidine alkaloidanticoronaviral agent;
antimalarial;
plant metabolite;
protein synthesis inhibitor
o-iodoxybenzoic acid
o-iodoxybenzoic acid: structure in first source. 1-hydroxy-1,3-dioxobenziodoxole : A benziodoxole compound having hydroxy and oxo substituents at the 1-position and an oxo substituent at the 3-position. It is a mild and efficient hypervalent iodine synthetic reagent used to carry out several selective oxidation reactions.		210benziodoxoleEC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor;
oxidising agent
potassium thiocyanate
potassium thiocyanate: RN given refers to cpd with MF of K-CHNS. potassium thiocyanate : A potassium salt which is the monopotassium salt of thiocyanic acid.		2.4110potassium salt
ConditionIndicatedRelationship StrengthStudiesTrials