| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
dihydroxyacetone
[no description available] | 1.98 | 1 | 0 | ketotriose;
primary alpha-hydroxy ketone | antifungal agent;
Escherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite |
glycerol
Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil. | 1.98 | 1 | 0 | alditol;
triol | algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent |
phenytoin
[no description available] | 1.97 | 1 | 0 | imidazolidine-2,4-dione | anticonvulsant;
drug allergen;
sodium channel blocker;
teratogenic agent |
alrestatin
alrestatin: aldose reductase inhibitor; RN given refers to parent cpd; structure | 1.97 | 1 | 0 | | |
pimagedine
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure. aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide. | 2.05 | 1 | 0 | guanidines;
one-carbon compound | EC 1.14.13.39 (nitric oxide synthase) inhibitor;
EC 1.4.3.4 (monoamine oxidase) inhibitor |
chlorpromazine
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.. chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety. | 1.97 | 1 | 0 | organochlorine compound;
phenothiazines;
tertiary amine | anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
phenothiazine antipsychotic drug |
phenobarbital
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups. | 1.97 | 1 | 0 | barbiturates | anticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative |
ponalrestat
[no description available] | 1.97 | 1 | 0 | phthalazines | |
sorbitol
D-glucitol : The D-enantiomer of glucitol (also known as D-sorbitol). | 2.67 | 3 | 0 | glucitol | cathartic;
Escherichia coli metabolite;
food humectant;
human metabolite;
laxative;
metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite;
sweetening agent |
edetic acid
Edetic Acid: A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive. | 1.97 | 1 | 0 | ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid | anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector |
mannitol
[no description available] | 1.98 | 1 | 0 | mannitol | allergen;
antiglaucoma drug;
compatible osmolytes;
Escherichia coli metabolite;
food anticaking agent;
food bulking agent;
food humectant;
food stabiliser;
food thickening agent;
hapten;
metabolite;
osmotic diuretic;
sweetening agent |
paeonol
paeonol: structure | 2.05 | 1 | 0 | methoxybenzenes;
phenols | metabolite |
2-piperidone
2-piperidone: structure given in first source. piperidin-2-one : A delta-lactam that is piperidine which is substituted by an oxo group at position 2. | 2.04 | 1 | 0 | delta-lactam;
piperidones | EC 1.2.1.88 (L-glutamate gamma-semialdehyde dehydrogenase) inhibitor |
galactose
aldohexose : A hexose with a (potential) aldehyde group at one end. | 1.98 | 1 | 0 | | |
calcium dobesilate
Calcium Dobesilate: A drug used to reduce hemorrhage in diabetic retinopathy. | 1.97 | 1 | 0 | | |
tolrestat
tolrestat: RN & structure given in first source | 1.97 | 1 | 0 | naphthalenes | EC 1.1.1.21 (aldehyde reductase) inhibitor |
3,3-tetramethyleneglutarimide
3,3-tetramethyleneglutarimide: structure in first source | 2.04 | 1 | 0 | | |
sorbinil
sorbinil: aldose reductase inhibitor. sorbinil : An azaspiro compound having a monofluoro-substituted chromane skeleton spiro-linked to an imidazolidinedione ring. | 2.66 | 3 | 0 | azaspiro compound;
chromanes;
imidazolidinone;
organofluorine compound;
oxaspiro compound | antioxidant;
EC 1.1.1.21 (aldehyde reductase) inhibitor |
d-tagatose
D-tagatopyranose : The pyranose form of D-tagatose. | 1.98 | 1 | 0 | D-tagatose | |
imidazolidines
[no description available] | 2.38 | 2 | 0 | azacycloalkane;
imidazolidines;
saturated organic heteromonocyclic parent | |
D-fructopyranose
[no description available] | 2.38 | 2 | 0 | cyclic hemiketal;
D-fructose;
fructopyranose | sweetening agent |
quercitrin
[no description available] | 1.97 | 1 | 0 | alpha-L-rhamnoside;
monosaccharide derivative;
quercetin O-glycoside;
tetrahydroxyflavone | antileishmanial agent;
antioxidant;
EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.14.18.1 (tyrosinase) inhibitor;
plant metabolite |
axillarin
axillarin: isolated from Pulicaria crispa or Filifdium sibiricum; structure given in first source. axillarin : A dimethoxyflavone that is the 3,6-dimethyl ether derivative of quercetagetin. | 1.97 | 1 | 0 | dimethoxyflavone;
tetrahydroxyflavone | plant metabolite |
palbinone
palbinone: terpenoid isolated from the roots of Paeonia albiflora; structure given in first source; showed strong inhibitory activity against 3-alpha-hydroxysteroid dehydrogenase | 2.05 | 1 | 0 | 16-oxo steroid | metabolite |
peoniflorin
[no description available] | 2.05 | 1 | 0 | | |
benzoylpaeoniflorin
benzoylpaeoniflorin: from Paeonia lactiflora | 2.05 | 1 | 0 | | |
galloylpaeoniflorin
galloylpaeoniflorin: an acylated monoterpene glucoside from paeony root; structure in first source | 2.05 | 1 | 0 | | |