galloylpaeoniflorin profile

galloylpaeoniflorin: an acylated monoterpene glucoside from paeony root; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	46882879
CHEMBL ID	1077642
MeSH ID	M0305335

Synonym
galloylpaeoniflorin
CHEMBL1077642
bdbm50378695

Excerpt	Reference	Relevance
"6'-O-Galloylpaeoniflorin (GPF) is a substance isolated from peony root with antioxidant and anti-inflammatory activities."	( 6'-O-Galloylpaeoniflorin attenuates Helicobacter pylori-associated gastritis via modulating Nrf2 pathway. Cao, Z; Wang, M; Yuan, X; Zhang, C; Zhang, J; Zhang, K; Zhang, Y; Zou, G, 2022)	1.69

Excerpt	Reference	Relevance
" Our findings suggest that biospecific live cell-based isolation combined with SPE and HPLC-MS/MS is an effective method for screening potential bioactive components in traditional Chinese medicines."	( Biospecific isolation and characterization of angiogenesis-promoting ingredients in Buyang Huanwu decoction using affinity chromatography on rat brain microvascular endothelial cells combined with solid-phase extraction, and HPLC-MS/MS. He, D; Liao, F; Meng, Y; Shen, X; Wang, L; Wu, Y; Yu, J; Zheng, H, 2018)	0.48

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	IC50 (µMol)	44.6000	0.0004	1.8773	10.0000	AID470242
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay ID	Title	Year	Journal	Article
AID1064200	Anticomplement activity in New Zealand White rabbit erythrocytes assessed as concentration required for 50% hemolytic inhibition by alternative pathway after 30 mins	2014	Journal of natural products, Jan-24, Volume: 77, Issue:1	Anticomplement monoterpenoid glucosides from the root bark of Paeonia suffruticosa.
AID1064190	Anticomplement activity in sheep erythrocytes in C9-depleted serum assessed as inhibition of hemolysis by classical pathway at 0.54 mM after 30 mins compound treated in normal human serum	2014	Journal of natural products, Jan-24, Volume: 77, Issue:1	Anticomplement monoterpenoid glucosides from the root bark of Paeonia suffruticosa.
AID1064193	Anticomplement activity in sheep erythrocytes in C1q-depleted serum assessed as inhibition of hemolysis by classical pathway at 0.54 mM after 30 mins compound treated in normal human serum	2014	Journal of natural products, Jan-24, Volume: 77, Issue:1	Anticomplement monoterpenoid glucosides from the root bark of Paeonia suffruticosa.
AID716418	Cytotoxicity against mouse RAW264.7 cells after 24 hrs	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	New monoterpene glycosides from Paeonia suffruticosa Andrews and their inhibition on NO production in LPS-induced RAW 264.7 cells.
AID471034	Antiinflammatory activity against mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production at 3 uM after 48 hrs by Griess reaction relative to control	2009	Journal of natural products, Sep, Volume: 72, Issue:9	Monoterpenes from Paeonia albiflora and their inhibitory activity on nitric oxide production by lipopolysaccharide-activated microglia.
AID1064191	Anticomplement activity in sheep erythrocytes in C5-depleted serum assessed as inhibition of hemolysis by classical pathway at 0.54 mM after 30 mins compound treated in normal human serum	2014	Journal of natural products, Jan-24, Volume: 77, Issue:1	Anticomplement monoterpenoid glucosides from the root bark of Paeonia suffruticosa.
AID1064201	Anticomplement activity in sheep erythrocytes assessed as concentration required for 50% hemolytic inhibition by classical pathway after 30 mins by spectrophotometry	2014	Journal of natural products, Jan-24, Volume: 77, Issue:1	Anticomplement monoterpenoid glucosides from the root bark of Paeonia suffruticosa.
AID470243	Inhibition of advanced glycation end product formation after 14 day in phosphate buffer at pH7.4 by spectrofluorimetry	2009	Journal of natural products, Aug, Volume: 72, Issue:8	Inhibitors of aldose reductase and formation of advanced glycation end-products in moutan cortex (Paeonia suffruticosa).
AID471037	Cytotoxicity against LPS-stimulated mouse N9 cells at 1 to 30 uM after 48 hrs by MTT assay	2009	Journal of natural products, Sep, Volume: 72, Issue:9	Monoterpenes from Paeonia albiflora and their inhibitory activity on nitric oxide production by lipopolysaccharide-activated microglia.
AID471036	Antiinflammatory activity against mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production at 30 uM after 48 hrs by Griess reaction relative to control	2009	Journal of natural products, Sep, Volume: 72, Issue:9	Monoterpenes from Paeonia albiflora and their inhibitory activity on nitric oxide production by lipopolysaccharide-activated microglia.
AID471033	Antiinflammatory activity against mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production at 1 uM after 48 hrs by Griess reaction relative to control	2009	Journal of natural products, Sep, Volume: 72, Issue:9	Monoterpenes from Paeonia albiflora and their inhibitory activity on nitric oxide production by lipopolysaccharide-activated microglia.
AID471035	Antiinflammatory activity against mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production at 10 uM after 48 hrs by Griess reaction relative to control	2009	Journal of natural products, Sep, Volume: 72, Issue:9	Monoterpenes from Paeonia albiflora and their inhibitory activity on nitric oxide production by lipopolysaccharide-activated microglia.
AID470242	Inhibition of Sprague-Dawley rat lens aldose reductase by spectrofluorimetry	2009	Journal of natural products, Aug, Volume: 72, Issue:8	Inhibitors of aldose reductase and formation of advanced glycation end-products in moutan cortex (Paeonia suffruticosa).
AID716419	Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reaction	2012	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 22, Issue:23	New monoterpene glycosides from Paeonia suffruticosa Andrews and their inhibition on NO production in LPS-induced RAW 264.7 cells.
AID1064192	Anticomplement activity in sheep erythrocytes in C3-depleted serum assessed as inhibition of hemolysis by classical pathway at 0.54 mM after 30 mins compound treated in normal human serum	2014	Journal of natural products, Jan-24, Volume: 77, Issue:1	Anticomplement monoterpenoid glucosides from the root bark of Paeonia suffruticosa.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (6.25)	18.2507
2000's	3 (18.75)	29.6817
2010's	8 (50.00)	24.3611
2020's	4 (25.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	16 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
gallic acid gallate : A trihydroxybenzoate that is the conjugate base of gallic acid.	2.76	3	trihydroxybenzoic acid	antineoplastic agent; antioxidant; apoptosis inducer; astringent; cyclooxygenase 2 inhibitor; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; geroprotector; human xenobiotic metabolite; plant metabolite
pimagedine pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure. aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.	2.05	1	guanidines; one-carbon compound	EC 1.14.13.39 (nitric oxide synthase) inhibitor; EC 1.4.3.4 (monoamine oxidase) inhibitor
methyl gallate methyl gallate: has both immunosuppressive and phytogenic antineoplastic activities; isolated from Acer saccharinum. methyl 3,4,5-trihydroxybenzoate : A gallate ester obtained by the formal condensation of gallic acid with methanol. It exhibits anti-oxidant, anti-tumor, anti-microbial and anti-inflammatory properties.	2.03	1	gallate ester	anti-inflammatory agent; antioxidant; plant metabolite
paeonol paeonol: structure	2.74	3	methoxybenzenes; phenols	metabolite
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	4.05	13	D-glucopyranose	epitope; mouse metabolite
1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose pentagalloylglucose: pentahydroxy gallic acid ester of glucose; a phytogenic antineoplastic agent and antibacterial agent. 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose : A galloyl-beta-D-glucose compound having five galloyl groups in the 1-, 2-, 3-, 4- and 6-positions.	2.03	1	gallate ester; galloyl beta-D-glucose	anti-inflammatory agent; antineoplastic agent; geroprotector; hepatoprotective agent; plant metabolite; radiation protective agent; radical scavenger
tetramethylene glutaric acid [no description available]	2.05	1
glycosides [no description available]	2.1	1
formononetin [no description available]	2.17	1	4'-methoxyisoflavones; 7-hydroxyisoflavones	phytoestrogen; plant metabolite
calycosin-7-o-beta-d-glucopyranoside calycosin-7-O-beta-D-glucoside: from Radix Astragali. calycosin-7-O-beta-D-glucoside : A glycosyloxyisoflavone that is calycosin substituted by a beta-D-glucopyranosyl residue at position at 7 via a glycosidic linkage.	2.17	1	4'-methoxyisoflavones; 7-hydroxyisoflavones 7-O-beta-D-glucoside; hydroxyisoflavone; monosaccharide derivative
palbinone palbinone: terpenoid isolated from the roots of Paeonia albiflora; structure given in first source; showed strong inhibitory activity against 3-alpha-hydroxysteroid dehydrogenase	2.05	1	16-oxo steroid	metabolite
oxypaeoniflora oxypaeoniflora: from Paeonia lactiflora	2.03	1	4-hydroxybenzoate ester; beta-D-glucoside; bridged compound; cyclic acetal; lactol; monoterpene glycoside	plant metabolite
albiflorin albiflorin: glucoside in peony roots. albiflorin : A monoterpene glycoside with formula C23H28O11, originally isolated from the roots of Paeonia lactiflora.	2.13	1	benzoate ester; beta-D-glucoside; bridged compound; gamma-lactone; monoterpene glycoside; secondary alcohol	neuroprotective agent; plant metabolite
peoniflorin [no description available]	2.75	3
benzoylpaeoniflorin benzoylpaeoniflorin: from Paeonia lactiflora	3.17	5
peoniflorin peoniflorin: from Radix and of Paeonia suffruticosa	3.03	4

Condition	Relationship Strength	Studies
Neuroblastoma A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)	7.41	1
Innate Inflammatory Response [description not available]	2.82	2
Experimental Lung Inflammation Inflammation of any part, segment or lobe, of the lung parenchyma.	2.41	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	7.82	2
Pneumonia Infection of the lung often accompanied by inflammation.	7.41	1
Infections, Helicobacter [description not available]	2.41	1
Gastritis Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders.	7.41	1
Helicobacter Infections Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.	2.41	1
Carcinoma, Non-Small Cell Lung [description not available]	2.25	1
Cancer of Lung [description not available]	2.25	1
Carcinoma, Non-Small-Cell Lung A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	2.25	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.25	1
Cerebral Ischemia [description not available]	2.17	1
Injury, Ischemia-Reperfusion [description not available]	2.17	1
Brain Ischemia Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.	2.17	1
Reperfusion Injury Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.	2.17	1
Dermatoses [description not available]	2.1	1
Skin Diseases Diseases involving the DERMIS or EPIDERMIS.	2.1	1
Lung Injury, Acute [description not available]	2.1	1
Acute Lung Injury A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).	2.1	1

galloylpaeoniflorin

Description

Cross-References

Synonyms (3)

Research Excerpts

Overview

Compound-Compound Interactions

Protein Targets (1)

Inhibition Measurements

Bioassays (15)

Research

Studies (16)

Study Types

galloylpaeoniflorin

Description

Cross-References

Synonyms (3)

Research Excerpts

Overview

Compound-Compound Interactions

Protein Targets (1)

Inhibition Measurements

Bioassays (15)

Research

Studies (16)

Study Types

Related Drugs (16)

Related Conditions (20)